Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth
Drozdzik A, Kurzawski M, Lener A, Kozak M, Banach J, Drozdzik M. Matrix metalloproteinase‐3 gene polymorphism in renal transplant patients with gingival overgrowth. J Periodont Res 2009; doi: 10.1111/j.1600‐0765.2009.01221.x. © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard Backgr...
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| description | Drozdzik A, Kurzawski M, Lener A, Kozak M, Banach J, Drozdzik M. Matrix metalloproteinase‐3 gene polymorphism in renal transplant patients with gingival overgrowth. J Periodont Res 2009; doi: 10.1111/j.1600‐0765.2009.01221.x. © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Background and Objective: Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporine use results from reduced degradation of extracellular matrix in the gingiva. Matrix metalloproteinase‐3 (MMP‐3) is involved in biodegradation of the extracellular matrix, and its inhibition may contribute to an abnormal accumulation of fibronectin and proteoglycans, which are MMP‐3 substrates. The aim of this study was to investigate whether an association exists between MMP‐3 genotypes and gingival enlargement in kidney transplant patients medicated with cyclosporine A.
Material and Methods: Sixty‐four unrelated kidney transplant patients suffering from gingival overgrowth, as well as 111 control transplant patients without gingival overgrowth, were enrolled in the study. Gingival overgrowth was assessed 6 mo after transplantation. During the post‐transplant period all patients were given cyclosporine A as a principal immunosuppressive agent. MMP‐3 polymorphism was determined using a PCR restriction fragment length polymorphism assay.
Results: In kidney transplant patients suffering from gingival overgrowth the mean gingival overgrowth score was 1.35 ± 0.57, whereas in control subjects the mean gingival overgrowth score was 0.0. The distribution of MMP‐3‐1178A/*dupA alleles among all kidney transplant patients, as well as in the two study subgroups, did not differ significantly from Hardy–Weinberg equilibrium. The frequency of the MMP‐3‐1171*A/*A genotype (28.1% for gingival overgrowth vs. 26.1% for controls) and of the MMP‐3‐1171*dupA/*dupA genotype (32.8% for gingival overgrowth vs. 22.5% for controls) was similar for both study groups. The risk of gingival overgrowth was lowest among patients carrying the MMP‐3‐1171*A/*dupA genotype (odds ratio 0.52), but this did not differ markedly from the other genotypes.
Conclusion: No association between MMP‐3 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A. |
| doi_str_mv | 10.1111/j.1600-0765.2009.01221.x |
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Background and Objective: Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporine use results from reduced degradation of extracellular matrix in the gingiva. Matrix metalloproteinase‐3 (MMP‐3) is involved in biodegradation of the extracellular matrix, and its inhibition may contribute to an abnormal accumulation of fibronectin and proteoglycans, which are MMP‐3 substrates. The aim of this study was to investigate whether an association exists between MMP‐3 genotypes and gingival enlargement in kidney transplant patients medicated with cyclosporine A.
Material and Methods: Sixty‐four unrelated kidney transplant patients suffering from gingival overgrowth, as well as 111 control transplant patients without gingival overgrowth, were enrolled in the study. Gingival overgrowth was assessed 6 mo after transplantation. During the post‐transplant period all patients were given cyclosporine A as a principal immunosuppressive agent. MMP‐3 polymorphism was determined using a PCR restriction fragment length polymorphism assay.
Results: In kidney transplant patients suffering from gingival overgrowth the mean gingival overgrowth score was 1.35 ± 0.57, whereas in control subjects the mean gingival overgrowth score was 0.0. The distribution of MMP‐3‐1178A/*dupA alleles among all kidney transplant patients, as well as in the two study subgroups, did not differ significantly from Hardy–Weinberg equilibrium. The frequency of the MMP‐3‐1171*A/*A genotype (28.1% for gingival overgrowth vs. 26.1% for controls) and of the MMP‐3‐1171*dupA/*dupA genotype (32.8% for gingival overgrowth vs. 22.5% for controls) was similar for both study groups. The risk of gingival overgrowth was lowest among patients carrying the MMP‐3‐1171*A/*dupA genotype (odds ratio 0.52), but this did not differ markedly from the other genotypes.
Conclusion: No association between MMP‐3 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/j.1600-0765.2009.01221.x</identifier><identifier>PMID: 19778329</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenine ; Adult ; Aged ; Alleles ; Biological and medical sciences ; Cyclosporine - adverse effects ; Dentistry ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Follow-Up Studies ; Gene Frequency ; Genotype ; gingival overgrowth ; Gingival Overgrowth - enzymology ; Gingival Overgrowth - etiology ; Humans ; Immunosuppressive Agents - adverse effects ; Kidney Transplantation ; Male ; Matrix Metalloproteinase 3 - genetics ; Medical sciences ; Middle Aged ; MMP-3 ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Polymerase Chain Reaction ; polymorphism ; Polymorphism, Genetic - genetics ; Polymorphism, Restriction Fragment Length ; Promoter Regions, Genetic - genetics ; Young Adult</subject><ispartof>Journal of periodontal research, 2010-02, Vol.45 (1), p.143-147</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4861-3aeda2a2991f2f8605ce32b93ee670ac336b58915b348fdf8ddcfbb561bbc1803</citedby><cites>FETCH-LOGICAL-c4861-3aeda2a2991f2f8605ce32b93ee670ac336b58915b348fdf8ddcfbb561bbc1803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0765.2009.01221.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0765.2009.01221.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22283153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19778329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drozdzik, A.</creatorcontrib><creatorcontrib>Kurzawski, M.</creatorcontrib><creatorcontrib>Lener, A.</creatorcontrib><creatorcontrib>Kozak, M.</creatorcontrib><creatorcontrib>Banach, J.</creatorcontrib><creatorcontrib>Drozdzik, M.</creatorcontrib><title>Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth</title><title>Journal of periodontal research</title><addtitle>J Periodontal Res</addtitle><description>Drozdzik A, Kurzawski M, Lener A, Kozak M, Banach J, Drozdzik M. Matrix metalloproteinase‐3 gene polymorphism in renal transplant patients with gingival overgrowth. J Periodont Res 2009; doi: 10.1111/j.1600‐0765.2009.01221.x. © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Background and Objective: Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporine use results from reduced degradation of extracellular matrix in the gingiva. Matrix metalloproteinase‐3 (MMP‐3) is involved in biodegradation of the extracellular matrix, and its inhibition may contribute to an abnormal accumulation of fibronectin and proteoglycans, which are MMP‐3 substrates. The aim of this study was to investigate whether an association exists between MMP‐3 genotypes and gingival enlargement in kidney transplant patients medicated with cyclosporine A.
Material and Methods: Sixty‐four unrelated kidney transplant patients suffering from gingival overgrowth, as well as 111 control transplant patients without gingival overgrowth, were enrolled in the study. Gingival overgrowth was assessed 6 mo after transplantation. During the post‐transplant period all patients were given cyclosporine A as a principal immunosuppressive agent. MMP‐3 polymorphism was determined using a PCR restriction fragment length polymorphism assay.
Results: In kidney transplant patients suffering from gingival overgrowth the mean gingival overgrowth score was 1.35 ± 0.57, whereas in control subjects the mean gingival overgrowth score was 0.0. The distribution of MMP‐3‐1178A/*dupA alleles among all kidney transplant patients, as well as in the two study subgroups, did not differ significantly from Hardy–Weinberg equilibrium. The frequency of the MMP‐3‐1171*A/*A genotype (28.1% for gingival overgrowth vs. 26.1% for controls) and of the MMP‐3‐1171*dupA/*dupA genotype (32.8% for gingival overgrowth vs. 22.5% for controls) was similar for both study groups. The risk of gingival overgrowth was lowest among patients carrying the MMP‐3‐1171*A/*dupA genotype (odds ratio 0.52), but this did not differ markedly from the other genotypes.
Conclusion: No association between MMP‐3 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A.</description><subject>Adenine</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Cyclosporine - adverse effects</subject><subject>Dentistry</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>gingival overgrowth</subject><subject>Gingival Overgrowth - enzymology</subject><subject>Gingival Overgrowth - etiology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Matrix Metalloproteinase 3 - genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MMP-3</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymerase Chain Reaction</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Young Adult</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEURi1ERUPLX0DeIFYz-JHxeBYsoJRCVR6CoC4te-ZO4uB5YDtN8u_rIVHY4o1t-XzX9x6EMCU5TevNOqeCkIyUosgZIVVOKGM03z1Bs9PDUzQjhLGMz-X8HD0PYU3SXZTVM3ROq7KUnFUzZL7o6O0OdxC1c8Pohwi21wEyjpfQAx4Ht-8GP65s6LDtsYdeOxy97sPodB_xqKOFPga8tXGFl7Zf2odEDA_gl37YxtUlOmu1C_DiuF-gXx-vF1efsrtvN5-v3t1l9VwKmnENjWaaVRVtWSsFKWrgzFQcQJRE15wLU8iKFiZN1DatbJq6NaYQ1JiaSsIv0OtD3TTEnw2EqDobanCpSxg2QZWcF2zOKE-kPJC1H0Lw0KrR2077vaJETYLVWk0e1eRRTYLVX8Fql6Ivj59sTAfNv-DRaAJeHQEdau3aJKq24cQxxiSnxdTD2wO3tQ72_92Auv1xPZ1SPjvkbYiwO-W1_61EyctC3X-9Ud8_LBbs_f1PteCPB5SoIA</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Drozdzik, A.</creator><creator>Kurzawski, M.</creator><creator>Lener, A.</creator><creator>Kozak, M.</creator><creator>Banach, J.</creator><creator>Drozdzik, M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201002</creationdate><title>Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth</title><author>Drozdzik, A. ; Kurzawski, M. ; Lener, A. ; Kozak, M. ; Banach, J. ; Drozdzik, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4861-3aeda2a2991f2f8605ce32b93ee670ac336b58915b348fdf8ddcfbb561bbc1803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenine</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Cyclosporine - adverse effects</topic><topic>Dentistry</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>gingival overgrowth</topic><topic>Gingival Overgrowth - enzymology</topic><topic>Gingival Overgrowth - etiology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Matrix Metalloproteinase 3 - genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MMP-3</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymerase Chain Reaction</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drozdzik, A.</creatorcontrib><creatorcontrib>Kurzawski, M.</creatorcontrib><creatorcontrib>Lener, A.</creatorcontrib><creatorcontrib>Kozak, M.</creatorcontrib><creatorcontrib>Banach, J.</creatorcontrib><creatorcontrib>Drozdzik, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drozdzik, A.</au><au>Kurzawski, M.</au><au>Lener, A.</au><au>Kozak, M.</au><au>Banach, J.</au><au>Drozdzik, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth</atitle><jtitle>Journal of periodontal research</jtitle><addtitle>J Periodontal Res</addtitle><date>2010-02</date><risdate>2010</risdate><volume>45</volume><issue>1</issue><spage>143</spage><epage>147</epage><pages>143-147</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract>Drozdzik A, Kurzawski M, Lener A, Kozak M, Banach J, Drozdzik M. Matrix metalloproteinase‐3 gene polymorphism in renal transplant patients with gingival overgrowth. J Periodont Res 2009; doi: 10.1111/j.1600‐0765.2009.01221.x. © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Background and Objective: Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporine use results from reduced degradation of extracellular matrix in the gingiva. Matrix metalloproteinase‐3 (MMP‐3) is involved in biodegradation of the extracellular matrix, and its inhibition may contribute to an abnormal accumulation of fibronectin and proteoglycans, which are MMP‐3 substrates. The aim of this study was to investigate whether an association exists between MMP‐3 genotypes and gingival enlargement in kidney transplant patients medicated with cyclosporine A.
Material and Methods: Sixty‐four unrelated kidney transplant patients suffering from gingival overgrowth, as well as 111 control transplant patients without gingival overgrowth, were enrolled in the study. Gingival overgrowth was assessed 6 mo after transplantation. During the post‐transplant period all patients were given cyclosporine A as a principal immunosuppressive agent. MMP‐3 polymorphism was determined using a PCR restriction fragment length polymorphism assay.
Results: In kidney transplant patients suffering from gingival overgrowth the mean gingival overgrowth score was 1.35 ± 0.57, whereas in control subjects the mean gingival overgrowth score was 0.0. The distribution of MMP‐3‐1178A/*dupA alleles among all kidney transplant patients, as well as in the two study subgroups, did not differ significantly from Hardy–Weinberg equilibrium. The frequency of the MMP‐3‐1171*A/*A genotype (28.1% for gingival overgrowth vs. 26.1% for controls) and of the MMP‐3‐1171*dupA/*dupA genotype (32.8% for gingival overgrowth vs. 22.5% for controls) was similar for both study groups. The risk of gingival overgrowth was lowest among patients carrying the MMP‐3‐1171*A/*dupA genotype (odds ratio 0.52), but this did not differ markedly from the other genotypes.
Conclusion: No association between MMP‐3 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19778329</pmid><doi>10.1111/j.1600-0765.2009.01221.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenine Adult Aged Alleles Biological and medical sciences Cyclosporine - adverse effects Dentistry Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Follow-Up Studies Gene Frequency Genotype gingival overgrowth Gingival Overgrowth - enzymology Gingival Overgrowth - etiology Humans Immunosuppressive Agents - adverse effects Kidney Transplantation Male Matrix Metalloproteinase 3 - genetics Medical sciences Middle Aged MMP-3 Non tumoral diseases Otorhinolaryngology. Stomatology Polymerase Chain Reaction polymorphism Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Promoter Regions, Genetic - genetics Young Adult |
| title | Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth |
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