Silica nanoparticle coated liposomes: A new type of hybrid nanocapsule for proteins

A hybrid silica–liposome nanocapsule system containing insulin has been developed and the encapsulation, protection and release properties are evaluated. The formulation strategy is based on using insulin-loaded 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and cholesterol liposomes as a template for...

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Veröffentlicht in:	International journal of pharmaceutics 2010-06, Vol.392 (1), p.285-293
Hauptverfasser:	Mohanraj, Vellore J., Barnes, Timothy J., Prestidge, Clive A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Biological and medical sciences Drug Compounding Encapsulation Gastric Juice - chemistry General pharmacology Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Insulin - administration & dosage Insulin - chemistry Insulin release Kinetics Lipolysis Liposomes Medical sciences Microscopy, Electron, Scanning Models, Biological Nanocapsules - chemistry Nanoparticles - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phospholipids - chemistry Silica nanoparticles Silicon Dioxide - chemistry Surface Properties
Online-Zugang:	Volltext
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