HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children
Abstract Background Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. Aim of the study To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. Patients We tested 31 Libyan childr...
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| Veröffentlicht in: | Digestive and liver disease 2010-06, Vol.42 (6), p.425-427 |
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| creator | Alarida, Kamla Harown, Jumma Di Pierro, Maria Rosaria Drago, Sandro Catassi, Carlo |
| description | Abstract Background Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. Aim of the study To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. Patients We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9). Methods HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy). Results The HLA-DQ pattern of the 31 CD children was: hetero DQ2 ( n = 15), DQ2 with homo β2 (10), DQ8 and β2 positive (3), DQ8 (2), and hetero β2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 ( n = 36), hetero β2 (30), DQ2–DQ8 negative (23), DQ8 (19), α5 (14), DQ2 with homo β (12), homo β2 (10), DQ8 and β2 positive (7), and DQ2/DQ8 (5). Conclusions HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of “high-risk” genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD. |
| doi_str_mv | 10.1016/j.dld.2009.09.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733522319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1590865809003727</els_id><sourcerecordid>733522319</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-8286ab6ad8fdbe04092d919b166ebb76cd47c275722810d92c5742b78591d63f3</originalsourceid><addsrcrecordid>eNp9kVtr4zAQhUXZ0vsP6Mvit31yOpJtXSgsLb1DoJS2z0KWJhuljp1KTsH_vnITWOhDYUADc85h9A0hpxQmFCg_W0xc4yYMQE3GgnKHHFApZF5UnP1KfaUgl7yS--QwxgUAo7yCPbJPlaRKcHlALu6nl_n1E8tM67LUyOwftl0_rDBmvs0sNt7Yr-EcTdPPh2zq68Gkydw3LmB7THZnpol4sn2PyOvtzcvVfT59vHu4upzmtgTR55JJbmpunJy5GqEExZyiqqacY10Lbl0pLBOVYExScIrZSpSsFrJS1PFiVhyRP5vcVeje1xh7vfQxrdeYFrt11KIoKsYKqpKSbpQ2dDEGnOlV8EsTBk1Bj9z0QidueuSmx4IyeX5v09f1Et1_xxZUEpxvBJj--OEx6Gg9thadD2h77Tr_Y_zfb27b-NZb07zhgHHRrUOb4GmqI9Ogn8fDjXcDBVAIJopPuB2Pcg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733522319</pqid></control><display><type>article</type><title>HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Alarida, Kamla ; Harown, Jumma ; Di Pierro, Maria Rosaria ; Drago, Sandro ; Catassi, Carlo</creator><creatorcontrib>Alarida, Kamla ; Harown, Jumma ; Di Pierro, Maria Rosaria ; Drago, Sandro ; Catassi, Carlo</creatorcontrib><description>Abstract Background Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. Aim of the study To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. Patients We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9). Methods HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy). Results The HLA-DQ pattern of the 31 CD children was: hetero DQ2 ( n = 15), DQ2 with homo β2 (10), DQ8 and β2 positive (3), DQ8 (2), and hetero β2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 ( n = 36), hetero β2 (30), DQ2–DQ8 negative (23), DQ8 (19), α5 (14), DQ2 with homo β (12), homo β2 (10), DQ8 and β2 positive (7), and DQ2/DQ8 (5). Conclusions HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of “high-risk” genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2009.09.004</identifier><identifier>PMID: 19819768</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Celiac disease ; Celiac Disease - epidemiology ; Celiac Disease - genetics ; Celiac Disease - immunology ; Child ; Child, Preschool ; DNA - genetics ; Electrophoresis ; Epidemiology ; Female ; Gastroenterology and Hepatology ; Gene Expression ; Genetic Predisposition to Disease ; Genotype ; HLA-DQ Antigens - genetics ; HLA-DQ Antigens - immunology ; HLA-DQ genes ; Humans ; Libya - epidemiology ; Libyan population ; Male ; Polymerase Chain Reaction ; Prevalence ; Reference Values</subject><ispartof>Digestive and liver disease, 2010-06, Vol.42 (6), p.425-427</ispartof><rights>Editrice Gastroenterologica Italiana S.r.l.</rights><rights>2009 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-8286ab6ad8fdbe04092d919b166ebb76cd47c275722810d92c5742b78591d63f3</citedby><cites>FETCH-LOGICAL-c407t-8286ab6ad8fdbe04092d919b166ebb76cd47c275722810d92c5742b78591d63f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1590865809003727$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19819768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alarida, Kamla</creatorcontrib><creatorcontrib>Harown, Jumma</creatorcontrib><creatorcontrib>Di Pierro, Maria Rosaria</creatorcontrib><creatorcontrib>Drago, Sandro</creatorcontrib><creatorcontrib>Catassi, Carlo</creatorcontrib><title>HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Abstract Background Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. Aim of the study To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. Patients We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9). Methods HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy). Results The HLA-DQ pattern of the 31 CD children was: hetero DQ2 ( n = 15), DQ2 with homo β2 (10), DQ8 and β2 positive (3), DQ8 (2), and hetero β2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 ( n = 36), hetero β2 (30), DQ2–DQ8 negative (23), DQ8 (19), α5 (14), DQ2 with homo β (12), homo β2 (10), DQ8 and β2 positive (7), and DQ2/DQ8 (5). Conclusions HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of “high-risk” genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD.</description><subject>Adolescent</subject><subject>Celiac disease</subject><subject>Celiac Disease - epidemiology</subject><subject>Celiac Disease - genetics</subject><subject>Celiac Disease - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA - genetics</subject><subject>Electrophoresis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gene Expression</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ Antigens - immunology</subject><subject>HLA-DQ genes</subject><subject>Humans</subject><subject>Libya - epidemiology</subject><subject>Libyan population</subject><subject>Male</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>Reference Values</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVtr4zAQhUXZ0vsP6Mvit31yOpJtXSgsLb1DoJS2z0KWJhuljp1KTsH_vnITWOhDYUADc85h9A0hpxQmFCg_W0xc4yYMQE3GgnKHHFApZF5UnP1KfaUgl7yS--QwxgUAo7yCPbJPlaRKcHlALu6nl_n1E8tM67LUyOwftl0_rDBmvs0sNt7Yr-EcTdPPh2zq68Gkydw3LmB7THZnpol4sn2PyOvtzcvVfT59vHu4upzmtgTR55JJbmpunJy5GqEExZyiqqacY10Lbl0pLBOVYExScIrZSpSsFrJS1PFiVhyRP5vcVeje1xh7vfQxrdeYFrt11KIoKsYKqpKSbpQ2dDEGnOlV8EsTBk1Bj9z0QidueuSmx4IyeX5v09f1Et1_xxZUEpxvBJj--OEx6Gg9thadD2h77Tr_Y_zfb27b-NZb07zhgHHRrUOb4GmqI9Ogn8fDjXcDBVAIJopPuB2Pcg</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Alarida, Kamla</creator><creator>Harown, Jumma</creator><creator>Di Pierro, Maria Rosaria</creator><creator>Drago, Sandro</creator><creator>Catassi, Carlo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children</title><author>Alarida, Kamla ; Harown, Jumma ; Di Pierro, Maria Rosaria ; Drago, Sandro ; Catassi, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-8286ab6ad8fdbe04092d919b166ebb76cd47c275722810d92c5742b78591d63f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Celiac disease</topic><topic>Celiac Disease - epidemiology</topic><topic>Celiac Disease - genetics</topic><topic>Celiac Disease - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>DNA - genetics</topic><topic>Electrophoresis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gene Expression</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ Antigens - immunology</topic><topic>HLA-DQ genes</topic><topic>Humans</topic><topic>Libya - epidemiology</topic><topic>Libyan population</topic><topic>Male</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alarida, Kamla</creatorcontrib><creatorcontrib>Harown, Jumma</creatorcontrib><creatorcontrib>Di Pierro, Maria Rosaria</creatorcontrib><creatorcontrib>Drago, Sandro</creatorcontrib><creatorcontrib>Catassi, Carlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alarida, Kamla</au><au>Harown, Jumma</au><au>Di Pierro, Maria Rosaria</au><au>Drago, Sandro</au><au>Catassi, Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>42</volume><issue>6</issue><spage>425</spage><epage>427</epage><pages>425-427</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Abstract Background Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. Aim of the study To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. Patients We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9). Methods HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy). Results The HLA-DQ pattern of the 31 CD children was: hetero DQ2 ( n = 15), DQ2 with homo β2 (10), DQ8 and β2 positive (3), DQ8 (2), and hetero β2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 ( n = 36), hetero β2 (30), DQ2–DQ8 negative (23), DQ8 (19), α5 (14), DQ2 with homo β (12), homo β2 (10), DQ8 and β2 positive (7), and DQ2/DQ8 (5). Conclusions HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of “high-risk” genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>19819768</pmid><doi>10.1016/j.dld.2009.09.004</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Celiac disease Celiac Disease - epidemiology Celiac Disease - genetics Celiac Disease - immunology Child Child, Preschool DNA - genetics Electrophoresis Epidemiology Female Gastroenterology and Hepatology Gene Expression Genetic Predisposition to Disease Genotype HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology HLA-DQ genes Humans Libya - epidemiology Libyan population Male Polymerase Chain Reaction Prevalence Reference Values |
| title | HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children |
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