Ocular findings in sleep apnoea patients using continuous positive airway pressure
Purpose To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP). Methods One hundred and fifteen referrals investigated for OSAHS were included. Patients with OSAHS were compared with those with nor...
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| Veröffentlicht in: | Eye (London) 2010-05, Vol.24 (5), p.843-850 |
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| creator | Kadyan, A Asghar, J Dowson, L Sandramouli, S |
| description | Purpose
To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP).
Methods
One hundred and fifteen referrals investigated for OSAHS were included. Patients with OSAHS were compared with those with normal sleep study controls. Subgroup analysis for CPAP users and non-users was also carried out.
Results
OSAHS patients (
n
=89) compared with the controls (
n
=26) had higher ocular irritation symptoms (
P |
| doi_str_mv | 10.1038/eye.2009.212 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733518053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733518053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-df1fb11c863931c204912c0da073f4f957ec69f970c965967cb35ce11cbcd7793</originalsourceid><addsrcrecordid>eNp10E1r3DAQBmBRGppt2lvPRRRKL_V2JNmWdCyhH4FAILTQm9HKo6DglV2N3bL_PjK7JFDoSYd55tXwMvZGwFaAMp_wgFsJYLdSyGdsI2rdVk3d1M_ZBmwDlZTy1zl7SXQPUIYaXrBzYVsDUrcbdnvjl8FlHmLqY7ojHhOnAXHibkojOj65OWKaiS9U5tyPaY5pGRfi00hxjn-Qu5j_ugOfMhItGV-xs-AGwten94L9_Prlx-X36vrm29Xl5-vK17WZqz6IsBPCm1ZZJbyE2grpoXegVaiDbTT61garwdu2sa32O9V4LBs732tt1QX7cMyd8vh7QZq7fSSPw-ASlvs6rVQjDDSqyHf_yPtxyakc10lhaqGMMAV9PCKfR6KMoZty3Lt86AR0a9Ndabpbmy5LsvC3p8xlt8f-CZ-qLeD9CTjybgjZJR_p0UmpjbWwBlVHR2WU7jA_Hfefj_nRJzeXth8DC1rNSh4AxYKgbA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218413818</pqid></control><display><type>article</type><title>Ocular findings in sleep apnoea patients using continuous positive airway pressure</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Kadyan, A ; Asghar, J ; Dowson, L ; Sandramouli, S</creator><creatorcontrib>Kadyan, A ; Asghar, J ; Dowson, L ; Sandramouli, S</creatorcontrib><description>Purpose
To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP).
Methods
One hundred and fifteen referrals investigated for OSAHS were included. Patients with OSAHS were compared with those with normal sleep study controls. Subgroup analysis for CPAP users and non-users was also carried out.
Results
OSAHS patients (
n
=89) compared with the controls (
n
=26) had higher ocular irritation symptoms (
P
<0.001), abnormal tear break-up time (
P
<0.05) with increased upper (
P
<0.001) and lower (
P
<0.001) lid laxity. Floppy eyelid syndrome (FES) was noted in 31.5% (28/89) OSAHS patients
vs
3.8% (1/26) controls (
P
=0.005). Open angle glaucoma prevalence in OSAHS patients (3/89, 3.4%) was similar to the controls (1/26, 3.8%) (
P
=0.92). Sixty-seven (75.3%) OSAHS patients were using CPAP (average duration: 19.6±15.3 months). All CPAP users maintained a supine sleep posture to prevent mask edge leaks. A fifth of CPAP users (14/67) had experienced earlier episodes of conjunctivitis secondary to leaks. CPAP users had similar upper and lower lid laxity (
P
=0.746 and 0.633) to non-CPAP users, but a better tear film (
P
=0.029) and less ocular irritation (
P
=0.134).
Conclusion
OSAHS patients showed increased ocular irritation, abnormal tear film, lid laxity, and FES. The prevalence of glaucoma in our series was similar to normal population data of 2%,
P
=0.429, and may relate to use of CPAP in majority of the patients. More stable tear film in CPAP users was probably secondary to the supine sleep postures necessarily adopted with CPAP use.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2009.212</identifier><identifier>PMID: 19680276</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; clinical-study ; Continuous Positive Airway Pressure ; Corneal Topography ; Eye Diseases - epidemiology ; Eye Diseases - etiology ; Female ; Glaucoma and intraocular pressure ; Glaucoma, Open-Angle - epidemiology ; Humans ; Laboratory Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscellaneous ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Pneumology ; Prevalence ; Respiratory system : syndromes and miscellaneous diseases ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Sleep Apnea, Obstructive - therapy ; Surgery ; Surgical Oncology ; Tears - physiology ; Visual Fields ; Young Adult</subject><ispartof>Eye (London), 2010-05, Vol.24 (5), p.843-850</ispartof><rights>Royal College of Ophthalmologists 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-df1fb11c863931c204912c0da073f4f957ec69f970c965967cb35ce11cbcd7793</citedby><cites>FETCH-LOGICAL-c448t-df1fb11c863931c204912c0da073f4f957ec69f970c965967cb35ce11cbcd7793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22789902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19680276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadyan, A</creatorcontrib><creatorcontrib>Asghar, J</creatorcontrib><creatorcontrib>Dowson, L</creatorcontrib><creatorcontrib>Sandramouli, S</creatorcontrib><title>Ocular findings in sleep apnoea patients using continuous positive airway pressure</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP).
Methods
One hundred and fifteen referrals investigated for OSAHS were included. Patients with OSAHS were compared with those with normal sleep study controls. Subgroup analysis for CPAP users and non-users was also carried out.
Results
OSAHS patients (
n
=89) compared with the controls (
n
=26) had higher ocular irritation symptoms (
P
<0.001), abnormal tear break-up time (
P
<0.05) with increased upper (
P
<0.001) and lower (
P
<0.001) lid laxity. Floppy eyelid syndrome (FES) was noted in 31.5% (28/89) OSAHS patients
vs
3.8% (1/26) controls (
P
=0.005). Open angle glaucoma prevalence in OSAHS patients (3/89, 3.4%) was similar to the controls (1/26, 3.8%) (
P
=0.92). Sixty-seven (75.3%) OSAHS patients were using CPAP (average duration: 19.6±15.3 months). All CPAP users maintained a supine sleep posture to prevent mask edge leaks. A fifth of CPAP users (14/67) had experienced earlier episodes of conjunctivitis secondary to leaks. CPAP users had similar upper and lower lid laxity (
P
=0.746 and 0.633) to non-CPAP users, but a better tear film (
P
=0.029) and less ocular irritation (
P
=0.134).
Conclusion
OSAHS patients showed increased ocular irritation, abnormal tear film, lid laxity, and FES. The prevalence of glaucoma in our series was similar to normal population data of 2%,
P
=0.429, and may relate to use of CPAP in majority of the patients. More stable tear film in CPAP users was probably secondary to the supine sleep postures necessarily adopted with CPAP use.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>clinical-study</subject><subject>Continuous Positive Airway Pressure</subject><subject>Corneal Topography</subject><subject>Eye Diseases - epidemiology</subject><subject>Eye Diseases - etiology</subject><subject>Female</subject><subject>Glaucoma and intraocular pressure</subject><subject>Glaucoma, Open-Angle - epidemiology</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tears - physiology</subject><subject>Visual Fields</subject><subject>Young Adult</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10E1r3DAQBmBRGppt2lvPRRRKL_V2JNmWdCyhH4FAILTQm9HKo6DglV2N3bL_PjK7JFDoSYd55tXwMvZGwFaAMp_wgFsJYLdSyGdsI2rdVk3d1M_ZBmwDlZTy1zl7SXQPUIYaXrBzYVsDUrcbdnvjl8FlHmLqY7ojHhOnAXHibkojOj65OWKaiS9U5tyPaY5pGRfi00hxjn-Qu5j_ugOfMhItGV-xs-AGwten94L9_Prlx-X36vrm29Xl5-vK17WZqz6IsBPCm1ZZJbyE2grpoXegVaiDbTT61garwdu2sa32O9V4LBs732tt1QX7cMyd8vh7QZq7fSSPw-ASlvs6rVQjDDSqyHf_yPtxyakc10lhaqGMMAV9PCKfR6KMoZty3Lt86AR0a9Ndabpbmy5LsvC3p8xlt8f-CZ-qLeD9CTjybgjZJR_p0UmpjbWwBlVHR2WU7jA_Hfefj_nRJzeXth8DC1rNSh4AxYKgbA</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Kadyan, A</creator><creator>Asghar, J</creator><creator>Dowson, L</creator><creator>Sandramouli, S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Ocular findings in sleep apnoea patients using continuous positive airway pressure</title><author>Kadyan, A ; Asghar, J ; Dowson, L ; Sandramouli, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-df1fb11c863931c204912c0da073f4f957ec69f970c965967cb35ce11cbcd7793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>clinical-study</topic><topic>Continuous Positive Airway Pressure</topic><topic>Corneal Topography</topic><topic>Eye Diseases - epidemiology</topic><topic>Eye Diseases - etiology</topic><topic>Female</topic><topic>Glaucoma and intraocular pressure</topic><topic>Glaucoma, Open-Angle - epidemiology</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pneumology</topic><topic>Prevalence</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tears - physiology</topic><topic>Visual Fields</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadyan, A</creatorcontrib><creatorcontrib>Asghar, J</creatorcontrib><creatorcontrib>Dowson, L</creatorcontrib><creatorcontrib>Sandramouli, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadyan, A</au><au>Asghar, J</au><au>Dowson, L</au><au>Sandramouli, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ocular findings in sleep apnoea patients using continuous positive airway pressure</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>24</volume><issue>5</issue><spage>843</spage><epage>850</epage><pages>843-850</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Purpose
To describe ocular findings in patients with established obstructive sleep apnoea hypopnoea syndrome (OSAHS) using continuous positive airway pressure (CPAP).
Methods
One hundred and fifteen referrals investigated for OSAHS were included. Patients with OSAHS were compared with those with normal sleep study controls. Subgroup analysis for CPAP users and non-users was also carried out.
Results
OSAHS patients (
n
=89) compared with the controls (
n
=26) had higher ocular irritation symptoms (
P
<0.001), abnormal tear break-up time (
P
<0.05) with increased upper (
P
<0.001) and lower (
P
<0.001) lid laxity. Floppy eyelid syndrome (FES) was noted in 31.5% (28/89) OSAHS patients
vs
3.8% (1/26) controls (
P
=0.005). Open angle glaucoma prevalence in OSAHS patients (3/89, 3.4%) was similar to the controls (1/26, 3.8%) (
P
=0.92). Sixty-seven (75.3%) OSAHS patients were using CPAP (average duration: 19.6±15.3 months). All CPAP users maintained a supine sleep posture to prevent mask edge leaks. A fifth of CPAP users (14/67) had experienced earlier episodes of conjunctivitis secondary to leaks. CPAP users had similar upper and lower lid laxity (
P
=0.746 and 0.633) to non-CPAP users, but a better tear film (
P
=0.029) and less ocular irritation (
P
=0.134).
Conclusion
OSAHS patients showed increased ocular irritation, abnormal tear film, lid laxity, and FES. The prevalence of glaucoma in our series was similar to normal population data of 2%,
P
=0.429, and may relate to use of CPAP in majority of the patients. More stable tear film in CPAP users was probably secondary to the supine sleep postures necessarily adopted with CPAP use.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19680276</pmid><doi>10.1038/eye.2009.212</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Eye (London), 2010-05, Vol.24 (5), p.843-850 |
| issn | 0950-222X 1476-5454 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences clinical-study Continuous Positive Airway Pressure Corneal Topography Eye Diseases - epidemiology Eye Diseases - etiology Female Glaucoma and intraocular pressure Glaucoma, Open-Angle - epidemiology Humans Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous Ophthalmology Pharmaceutical Sciences/Technology Pneumology Prevalence Respiratory system : syndromes and miscellaneous diseases Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Sleep Apnea, Obstructive - therapy Surgery Surgical Oncology Tears - physiology Visual Fields Young Adult |
| title | Ocular findings in sleep apnoea patients using continuous positive airway pressure |
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