Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma
Background/purpose The majority of hepatocellular carcinomas are associated with chronic infection with hepatitis B or C virus. Recently, however, the proportion of non-B non-C hepatocellular carcinomas has been increasing. It is necessary to determine the optimal surgical approach for non-B non-C h...
Gespeichert in:
| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2010-05, Vol.17 (3), p.291-295 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 295 |
|---|---|
| container_issue | 3 |
| container_start_page | 291 |
| container_title | Journal of hepato-biliary-pancreatic sciences |
| container_volume | 17 |
| creator | Shinkawa, Hiroji Uenishi, Takahiro Takemura, Shigekazu Ohba, Kazuki Ogawa, Masao Ichikawa, Tsuyoshi Kodai, Shintaro Yamamoto, Takatsugu Tanaka, Hiromu Kubo, Shoji |
| description | Background/purpose
The majority of hepatocellular carcinomas are associated with chronic infection with hepatitis B or C virus. Recently, however, the proportion of non-B non-C hepatocellular carcinomas has been increasing. It is necessary to determine the optimal surgical approach for non-B non-C hepatocellular carcinoma.
Methods
Seventy-seven patients with non-B non-C hepatocellular carcinoma who underwent curative hepatic resection were included in this study. Univariate and multivariate analyses were performed to clarify risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma.
Results
On univariate analysis, surgical margin |
| doi_str_mv | 10.1007/s00534-009-0186-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733518004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3805849671</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5385-4147ef0048e8539f1c851560ce45f96cb1e20d6194a6ecdeea4a2e91ff6102b13</originalsourceid><addsrcrecordid>eNqFkE9P3DAQxa2KCtCWD8ClitQDJ4MnthP7WFaUP0Kirdqz5fWO29BsnNpJ0X57nGZVKiTEHGZ8-L3np0fIMbBTYKw-S4xJLihjmjJQFeVvyGG-ilZalXv_3rU4IEcp3bM8HLjmbJ8cgK5VXSp5SL58bdKvwls3hJgKH2LRhzSEHqMdmj9YRHRjjNg5LIIvutDR8797WfzE3g7BYduOrY2Fs9E1XdjYd-Stt23Co91dkO-fLr4tr-jt3eX18uMtdZIrSQWIGj1jQqGSXHtwSoKsmEMhva7cCrBk6wq0sBW6NaIVtkQN3lfAyhXwBTmZffsYfo-YBrNp0hTHdhjGZGrOJaj8QSY_PCPvwxi7HM5ADSClkrrMFMyUiyGliN70sdnYuDXAzNS4mRs3uXEzNW541rzfOY-rDa6fFLt-M1DPwEPT4vZ1R3Nzdf4ZKjEpy1mZsqj7gfG_0C_meQQlGZq5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1711558592</pqid></control><display><type>article</type><title>Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Shinkawa, Hiroji ; Uenishi, Takahiro ; Takemura, Shigekazu ; Ohba, Kazuki ; Ogawa, Masao ; Ichikawa, Tsuyoshi ; Kodai, Shintaro ; Yamamoto, Takatsugu ; Tanaka, Hiromu ; Kubo, Shoji</creator><creatorcontrib>Shinkawa, Hiroji ; Uenishi, Takahiro ; Takemura, Shigekazu ; Ohba, Kazuki ; Ogawa, Masao ; Ichikawa, Tsuyoshi ; Kodai, Shintaro ; Yamamoto, Takatsugu ; Tanaka, Hiromu ; Kubo, Shoji</creatorcontrib><description>Background/purpose
The majority of hepatocellular carcinomas are associated with chronic infection with hepatitis B or C virus. Recently, however, the proportion of non-B non-C hepatocellular carcinomas has been increasing. It is necessary to determine the optimal surgical approach for non-B non-C hepatocellular carcinoma.
Methods
Seventy-seven patients with non-B non-C hepatocellular carcinoma who underwent curative hepatic resection were included in this study. Univariate and multivariate analyses were performed to clarify risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma.
Results
On univariate analysis, surgical margin <5 mm (
P
= 0.001) and the presence of multiple tumors (
P
= 0.002) were significantly associated with lower disease-free survival rate. On multivariate analysis, surgical margin <5 mm and the presence of multiple tumors were independent risk factors for postoperative recurrence.
Conclusion
Curative resection with adequate surgical margins for single non-B non-C hepatocellular carcinoma can achieve a good outcome.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1007/s00534-009-0186-3</identifier><identifier>PMID: 19787285</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Disease-Free Survival ; Female ; Gastroenterology ; Hepatectomy ; Hepatology ; Humans ; Liver cancer ; Liver cirrhosis ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; non‐B non‐C HCC ; Original Article ; risk factor ; Risk Factors ; surgical margin ; Surgical Oncology</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2010-05, Vol.17 (3), p.291-295</ispartof><rights>Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2009</rights><rights>2010 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>2010 Japanese Society of Hepato-Biliary-Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5385-4147ef0048e8539f1c851560ce45f96cb1e20d6194a6ecdeea4a2e91ff6102b13</citedby><cites>FETCH-LOGICAL-c5385-4147ef0048e8539f1c851560ce45f96cb1e20d6194a6ecdeea4a2e91ff6102b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs00534-009-0186-3$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs00534-009-0186-3$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19787285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinkawa, Hiroji</creatorcontrib><creatorcontrib>Uenishi, Takahiro</creatorcontrib><creatorcontrib>Takemura, Shigekazu</creatorcontrib><creatorcontrib>Ohba, Kazuki</creatorcontrib><creatorcontrib>Ogawa, Masao</creatorcontrib><creatorcontrib>Ichikawa, Tsuyoshi</creatorcontrib><creatorcontrib>Kodai, Shintaro</creatorcontrib><creatorcontrib>Yamamoto, Takatsugu</creatorcontrib><creatorcontrib>Tanaka, Hiromu</creatorcontrib><creatorcontrib>Kubo, Shoji</creatorcontrib><title>Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background/purpose
The majority of hepatocellular carcinomas are associated with chronic infection with hepatitis B or C virus. Recently, however, the proportion of non-B non-C hepatocellular carcinomas has been increasing. It is necessary to determine the optimal surgical approach for non-B non-C hepatocellular carcinoma.
Methods
Seventy-seven patients with non-B non-C hepatocellular carcinoma who underwent curative hepatic resection were included in this study. Univariate and multivariate analyses were performed to clarify risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma.
Results
On univariate analysis, surgical margin <5 mm (
P
= 0.001) and the presence of multiple tumors (
P
= 0.002) were significantly associated with lower disease-free survival rate. On multivariate analysis, surgical margin <5 mm and the presence of multiple tumors were independent risk factors for postoperative recurrence.
Conclusion
Curative resection with adequate surgical margins for single non-B non-C hepatocellular carcinoma can achieve a good outcome.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatectomy</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>non‐B non‐C HCC</subject><subject>Original Article</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>surgical margin</subject><subject>Surgical Oncology</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9P3DAQxa2KCtCWD8ClitQDJ4MnthP7WFaUP0Kirdqz5fWO29BsnNpJ0X57nGZVKiTEHGZ8-L3np0fIMbBTYKw-S4xJLihjmjJQFeVvyGG-ilZalXv_3rU4IEcp3bM8HLjmbJ8cgK5VXSp5SL58bdKvwls3hJgKH2LRhzSEHqMdmj9YRHRjjNg5LIIvutDR8797WfzE3g7BYduOrY2Fs9E1XdjYd-Stt23Co91dkO-fLr4tr-jt3eX18uMtdZIrSQWIGj1jQqGSXHtwSoKsmEMhva7cCrBk6wq0sBW6NaIVtkQN3lfAyhXwBTmZffsYfo-YBrNp0hTHdhjGZGrOJaj8QSY_PCPvwxi7HM5ADSClkrrMFMyUiyGliN70sdnYuDXAzNS4mRs3uXEzNW541rzfOY-rDa6fFLt-M1DPwEPT4vZ1R3Nzdf4ZKjEpy1mZsqj7gfG_0C_meQQlGZq5</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Shinkawa, Hiroji</creator><creator>Uenishi, Takahiro</creator><creator>Takemura, Shigekazu</creator><creator>Ohba, Kazuki</creator><creator>Ogawa, Masao</creator><creator>Ichikawa, Tsuyoshi</creator><creator>Kodai, Shintaro</creator><creator>Yamamoto, Takatsugu</creator><creator>Tanaka, Hiromu</creator><creator>Kubo, Shoji</creator><general>Springer Japan</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma</title><author>Shinkawa, Hiroji ; Uenishi, Takahiro ; Takemura, Shigekazu ; Ohba, Kazuki ; Ogawa, Masao ; Ichikawa, Tsuyoshi ; Kodai, Shintaro ; Yamamoto, Takatsugu ; Tanaka, Hiromu ; Kubo, Shoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5385-4147ef0048e8539f1c851560ce45f96cb1e20d6194a6ecdeea4a2e91ff6102b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatectomy</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>non‐B non‐C HCC</topic><topic>Original Article</topic><topic>risk factor</topic><topic>Risk Factors</topic><topic>surgical margin</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinkawa, Hiroji</creatorcontrib><creatorcontrib>Uenishi, Takahiro</creatorcontrib><creatorcontrib>Takemura, Shigekazu</creatorcontrib><creatorcontrib>Ohba, Kazuki</creatorcontrib><creatorcontrib>Ogawa, Masao</creatorcontrib><creatorcontrib>Ichikawa, Tsuyoshi</creatorcontrib><creatorcontrib>Kodai, Shintaro</creatorcontrib><creatorcontrib>Yamamoto, Takatsugu</creatorcontrib><creatorcontrib>Tanaka, Hiromu</creatorcontrib><creatorcontrib>Kubo, Shoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinkawa, Hiroji</au><au>Uenishi, Takahiro</au><au>Takemura, Shigekazu</au><au>Ohba, Kazuki</au><au>Ogawa, Masao</au><au>Ichikawa, Tsuyoshi</au><au>Kodai, Shintaro</au><au>Yamamoto, Takatsugu</au><au>Tanaka, Hiromu</au><au>Kubo, Shoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><stitle>J Hepatobiliary Pancreat Sci</stitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2010-05</date><risdate>2010</risdate><volume>17</volume><issue>3</issue><spage>291</spage><epage>295</epage><pages>291-295</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background/purpose
The majority of hepatocellular carcinomas are associated with chronic infection with hepatitis B or C virus. Recently, however, the proportion of non-B non-C hepatocellular carcinomas has been increasing. It is necessary to determine the optimal surgical approach for non-B non-C hepatocellular carcinoma.
Methods
Seventy-seven patients with non-B non-C hepatocellular carcinoma who underwent curative hepatic resection were included in this study. Univariate and multivariate analyses were performed to clarify risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma.
Results
On univariate analysis, surgical margin <5 mm (
P
= 0.001) and the presence of multiple tumors (
P
= 0.002) were significantly associated with lower disease-free survival rate. On multivariate analysis, surgical margin <5 mm and the presence of multiple tumors were independent risk factors for postoperative recurrence.
Conclusion
Curative resection with adequate surgical margins for single non-B non-C hepatocellular carcinoma can achieve a good outcome.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>19787285</pmid><doi>10.1007/s00534-009-0186-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1868-6974 |
| ispartof | Journal of hepato-biliary-pancreatic sciences, 2010-05, Vol.17 (3), p.291-295 |
| issn | 1868-6974 1868-6982 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733518004 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Disease-Free Survival Female Gastroenterology Hepatectomy Hepatology Humans Liver cancer Liver cirrhosis Liver Neoplasms - epidemiology Liver Neoplasms - etiology Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery non‐B non‐C HCC Original Article risk factor Risk Factors surgical margin Surgical Oncology |
| title | Risk factors for postoperative recurrence of non-B non-C hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T10%3A07%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20factors%20for%20postoperative%20recurrence%20of%20non-B%20non-C%20hepatocellular%20carcinoma&rft.jtitle=Journal%20of%20hepato-biliary-pancreatic%20sciences&rft.au=Shinkawa,%20Hiroji&rft.date=2010-05&rft.volume=17&rft.issue=3&rft.spage=291&rft.epage=295&rft.pages=291-295&rft.issn=1868-6974&rft.eissn=1868-6982&rft_id=info:doi/10.1007/s00534-009-0186-3&rft_dat=%3Cproquest_cross%3E3805849671%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1711558592&rft_id=info:pmid/19787285&rfr_iscdi=true |