Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation with diseased synovium becoming highly aggressive, attaching to the articular cartilage and bone to form what is termed a pannus. The formatio...
Gespeichert in:
| Veröffentlicht in: | Gene therapy 2003-06, Vol.10 (12), p.1055-1060 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1060 |
|---|---|
| container_issue | 12 |
| container_start_page | 1055 |
| container_title | Gene therapy |
| container_volume | 10 |
| creator | Yao, Q Wang, S Gambotto, A Glorioso, J C Evans, C H Robbins, P D Ghivizzani, S C Oligino, T J |
| description | Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation with diseased synovium becoming highly aggressive, attaching to the articular cartilage and bone to form what is termed a pannus. The formation of active pannus is central to erosive disease and resulting joint destruction. In this study, we examined the ability to eliminate the hyperplastic synovium by adenoviral-mediated gene transfer of human TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family that is able to induce apoptosis through interaction with receptors containing death domains, DR4 and DR5. Infection of synovial cells derived from RA patients with Ad.TRAIL resulted in significant apoptosis in three out of five lines. Moreover, primary rabbit synovial fibroblasts were also sensitive to Ad.TRAIL-mediated gene transfer. In a rabbit model of arthritis, intra-articular gene transfer of TRAIL induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. These results demonstrate that TRAIL can affect the viability of the cells populating the activated synovium in arthritic joints and suggest that the delivery of TRAIL to arthritic joints may represent a non-invasive mechanism for inducing pannus regression. |
| doi_str_mv | 10.1038/sj.gt.3301881 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_73351539</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A182889161</galeid><sourcerecordid>A182889161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-2432649bab0c3c485360bada74bbeafc86fc0052e32e071bc107364fd41799753</originalsourceid><addsrcrecordid>eNqF0s2L1DAYBvAiiju7evQqRdkFDx3z1SQ9LosfAwuCH-eQpmknQycZ86bi_vemTGEcUaSHluaXp33DUxQvMFpjROVb2K2HtKYUYSnxo2KFmeBVzTh5XKxQw5tKYCIvikuAHUKICUmeFheYCMExZ6vCbXyKutIxOTONOpa6sz78cFGP1d52TifblYP1tszMQ29jGfr52Y2l891kLJT6EA4pgIN5KSdto8tpZdRt61IJD3PetH9WPOn1CPb5cr8qvr1_9_XuY3X_6cPm7va-MrUUqSKMEs6aVrfIUMNkTTlqdacFa1ureyN5bxCqiaXEIoFbg5GgnPUdw6JpRE2viptj7iGG75OFpPYOjB1H7W2YQAlKa1zT5r8QSyFqUosMX_8Bd2GKPg-h8q8yjgWrUVav_qlyFKWMz1HrIxr0aJXzfchHafLV2b0zwdve5fe3WBIpG8xx3vDmbEM2yf5Mg54A1ObL53N785vdWj2mLYRxSi54OIfVEZoYAKLt1SG6vY4PCiM1t0rBTg1JLa3K_uUy2tTmUpz0UqMMrhegweixz1UxDk6OSUQQxqfxIS_5wcbTGf39y78AHrTijA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218733467</pqid></control><display><type>article</type><title>Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Yao, Q ; Wang, S ; Gambotto, A ; Glorioso, J C ; Evans, C H ; Robbins, P D ; Ghivizzani, S C ; Oligino, T J</creator><creatorcontrib>Yao, Q ; Wang, S ; Gambotto, A ; Glorioso, J C ; Evans, C H ; Robbins, P D ; Ghivizzani, S C ; Oligino, T J</creatorcontrib><description>Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation with diseased synovium becoming highly aggressive, attaching to the articular cartilage and bone to form what is termed a pannus. The formation of active pannus is central to erosive disease and resulting joint destruction. In this study, we examined the ability to eliminate the hyperplastic synovium by adenoviral-mediated gene transfer of human TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family that is able to induce apoptosis through interaction with receptors containing death domains, DR4 and DR5. Infection of synovial cells derived from RA patients with Ad.TRAIL resulted in significant apoptosis in three out of five lines. Moreover, primary rabbit synovial fibroblasts were also sensitive to Ad.TRAIL-mediated gene transfer. In a rabbit model of arthritis, intra-articular gene transfer of TRAIL induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. These results demonstrate that TRAIL can affect the viability of the cells populating the activated synovium in arthritic joints and suggest that the delivery of TRAIL to arthritic joints may represent a non-invasive mechanism for inducing pannus regression.</description><identifier>ISSN: 0969-7128</identifier><identifier>EISSN: 1476-5462</identifier><identifier>DOI: 10.1038/sj.gt.3301881</identifier><identifier>PMID: 12776164</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenoviridae - genetics ; Animals ; Apoptosis ; Apoptosis Regulatory Proteins ; Arthritis ; Arthritis, Experimental - pathology ; Arthritis, Experimental - therapy ; Arthritis, Rheumatoid - pathology ; Autoimmune diseases ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; brief-communication ; Cartilage ; Cartilage (articular) ; Cell Biology ; Cell Line ; Fibroblasts ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Gene Therapy ; Gene transfer ; Gene Transfer Techniques ; Genetic Therapy - methods ; Genetic Vectors ; Human Genetics ; Humans ; Hyperplasia ; Injections, Intra-Articular ; Joint diseases ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - physiology ; Molecular and cellular biology ; Nanotechnology ; Rabbits ; Rheumatoid arthritis ; Rheumatoid synovitis ; Synovial Membrane - pathology ; TNF-Related Apoptosis-Inducing Ligand ; TRAIL protein ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>Gene therapy, 2003-06, Vol.10 (12), p.1055-1060</ispartof><rights>Springer Nature Limited 2003</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2, 2003</rights><rights>Nature Publishing Group 2003.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-2432649bab0c3c485360bada74bbeafc86fc0052e32e071bc107364fd41799753</citedby><cites>FETCH-LOGICAL-c587t-2432649bab0c3c485360bada74bbeafc86fc0052e32e071bc107364fd41799753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.gt.3301881$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.gt.3301881$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14802011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12776164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Q</creatorcontrib><creatorcontrib>Wang, S</creatorcontrib><creatorcontrib>Gambotto, A</creatorcontrib><creatorcontrib>Glorioso, J C</creatorcontrib><creatorcontrib>Evans, C H</creatorcontrib><creatorcontrib>Robbins, P D</creatorcontrib><creatorcontrib>Ghivizzani, S C</creatorcontrib><creatorcontrib>Oligino, T J</creatorcontrib><title>Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium</title><title>Gene therapy</title><addtitle>Gene Ther</addtitle><addtitle>Gene Ther</addtitle><description>Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation with diseased synovium becoming highly aggressive, attaching to the articular cartilage and bone to form what is termed a pannus. The formation of active pannus is central to erosive disease and resulting joint destruction. In this study, we examined the ability to eliminate the hyperplastic synovium by adenoviral-mediated gene transfer of human TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family that is able to induce apoptosis through interaction with receptors containing death domains, DR4 and DR5. Infection of synovial cells derived from RA patients with Ad.TRAIL resulted in significant apoptosis in three out of five lines. Moreover, primary rabbit synovial fibroblasts were also sensitive to Ad.TRAIL-mediated gene transfer. In a rabbit model of arthritis, intra-articular gene transfer of TRAIL induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. These results demonstrate that TRAIL can affect the viability of the cells populating the activated synovium in arthritic joints and suggest that the delivery of TRAIL to arthritic joints may represent a non-invasive mechanism for inducing pannus regression.</description><subject>Adenoviridae - genetics</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis Regulatory Proteins</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - pathology</subject><subject>Arthritis, Experimental - therapy</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>brief-communication</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cell Biology</subject><subject>Cell Line</subject><subject>Fibroblasts</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Gene Therapy</subject><subject>Gene transfer</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Injections, Intra-Articular</subject><subject>Joint diseases</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Molecular and cellular biology</subject><subject>Nanotechnology</subject><subject>Rabbits</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid synovitis</subject><subject>Synovial Membrane - pathology</subject><subject>TNF-Related Apoptosis-Inducing Ligand</subject><subject>TRAIL protein</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0969-7128</issn><issn>1476-5462</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0s2L1DAYBvAiiju7evQqRdkFDx3z1SQ9LosfAwuCH-eQpmknQycZ86bi_vemTGEcUaSHluaXp33DUxQvMFpjROVb2K2HtKYUYSnxo2KFmeBVzTh5XKxQw5tKYCIvikuAHUKICUmeFheYCMExZ6vCbXyKutIxOTONOpa6sz78cFGP1d52TifblYP1tszMQ29jGfr52Y2l891kLJT6EA4pgIN5KSdto8tpZdRt61IJD3PetH9WPOn1CPb5cr8qvr1_9_XuY3X_6cPm7va-MrUUqSKMEs6aVrfIUMNkTTlqdacFa1ureyN5bxCqiaXEIoFbg5GgnPUdw6JpRE2viptj7iGG75OFpPYOjB1H7W2YQAlKa1zT5r8QSyFqUosMX_8Bd2GKPg-h8q8yjgWrUVav_qlyFKWMz1HrIxr0aJXzfchHafLV2b0zwdve5fe3WBIpG8xx3vDmbEM2yf5Mg54A1ObL53N785vdWj2mLYRxSi54OIfVEZoYAKLt1SG6vY4PCiM1t0rBTg1JLa3K_uUy2tTmUpz0UqMMrhegweixz1UxDk6OSUQQxqfxIS_5wcbTGf39y78AHrTijA</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Yao, Q</creator><creator>Wang, S</creator><creator>Gambotto, A</creator><creator>Glorioso, J C</creator><creator>Evans, C H</creator><creator>Robbins, P D</creator><creator>Ghivizzani, S C</creator><creator>Oligino, T J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium</title><author>Yao, Q ; Wang, S ; Gambotto, A ; Glorioso, J C ; Evans, C H ; Robbins, P D ; Ghivizzani, S C ; Oligino, T J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-2432649bab0c3c485360bada74bbeafc86fc0052e32e071bc107364fd41799753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenoviridae - genetics</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis Regulatory Proteins</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - pathology</topic><topic>Arthritis, Experimental - therapy</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>brief-communication</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cell Biology</topic><topic>Cell Line</topic><topic>Fibroblasts</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Gene Therapy</topic><topic>Gene transfer</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Injections, Intra-Articular</topic><topic>Joint diseases</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Molecular and cellular biology</topic><topic>Nanotechnology</topic><topic>Rabbits</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid synovitis</topic><topic>Synovial Membrane - pathology</topic><topic>TNF-Related Apoptosis-Inducing Ligand</topic><topic>TRAIL protein</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Q</creatorcontrib><creatorcontrib>Wang, S</creatorcontrib><creatorcontrib>Gambotto, A</creatorcontrib><creatorcontrib>Glorioso, J C</creatorcontrib><creatorcontrib>Evans, C H</creatorcontrib><creatorcontrib>Robbins, P D</creatorcontrib><creatorcontrib>Ghivizzani, S C</creatorcontrib><creatorcontrib>Oligino, T J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Q</au><au>Wang, S</au><au>Gambotto, A</au><au>Glorioso, J C</au><au>Evans, C H</au><au>Robbins, P D</au><au>Ghivizzani, S C</au><au>Oligino, T J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium</atitle><jtitle>Gene therapy</jtitle><stitle>Gene Ther</stitle><addtitle>Gene Ther</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>10</volume><issue>12</issue><spage>1055</spage><epage>1060</epage><pages>1055-1060</pages><issn>0969-7128</issn><eissn>1476-5462</eissn><abstract>Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation with diseased synovium becoming highly aggressive, attaching to the articular cartilage and bone to form what is termed a pannus. The formation of active pannus is central to erosive disease and resulting joint destruction. In this study, we examined the ability to eliminate the hyperplastic synovium by adenoviral-mediated gene transfer of human TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family that is able to induce apoptosis through interaction with receptors containing death domains, DR4 and DR5. Infection of synovial cells derived from RA patients with Ad.TRAIL resulted in significant apoptosis in three out of five lines. Moreover, primary rabbit synovial fibroblasts were also sensitive to Ad.TRAIL-mediated gene transfer. In a rabbit model of arthritis, intra-articular gene transfer of TRAIL induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. These results demonstrate that TRAIL can affect the viability of the cells populating the activated synovium in arthritic joints and suggest that the delivery of TRAIL to arthritic joints may represent a non-invasive mechanism for inducing pannus regression.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12776164</pmid><doi>10.1038/sj.gt.3301881</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-7128 |
| ispartof | Gene therapy, 2003-06, Vol.10 (12), p.1055-1060 |
| issn | 0969-7128 1476-5462 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73351539 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenoviridae - genetics Animals Apoptosis Apoptosis Regulatory Proteins Arthritis Arthritis, Experimental - pathology Arthritis, Experimental - therapy Arthritis, Rheumatoid - pathology Autoimmune diseases Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cartilage Cartilage (articular) Cell Biology Cell Line Fibroblasts Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors Human Genetics Humans Hyperplasia Injections, Intra-Articular Joint diseases Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Molecular and cellular biology Nanotechnology Rabbits Rheumatoid arthritis Rheumatoid synovitis Synovial Membrane - pathology TNF-Related Apoptosis-Inducing Ligand TRAIL protein Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology |
| title | Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A57%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intra-articular%20adenoviral-mediated%20gene%20transfer%20of%20trail%20induces%20apoptosis%20of%20arthritic%20rabbit%20synovium&rft.jtitle=Gene%20therapy&rft.au=Yao,%20Q&rft.date=2003-06-01&rft.volume=10&rft.issue=12&rft.spage=1055&rft.epage=1060&rft.pages=1055-1060&rft.issn=0969-7128&rft.eissn=1476-5462&rft_id=info:doi/10.1038/sj.gt.3301881&rft_dat=%3Cgale_proqu%3EA182889161%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218733467&rft_id=info:pmid/12776164&rft_galeid=A182889161&rfr_iscdi=true |