Conformational Studies of Covalently Grafted Poly(ethylene glycol) on Modified Solid Matrices Using X-ray Photoelectron Spectroscopy
Amine functionalized poly(ethylene glycols) (PEGs) with molecular weights 2000 and 4000 Da were covalently grafted onto carboxy modified hydrophilic Sephadex derivatives and hydrophobic polystyrene derivatives using anhydrous amine conjugation methods. Varying PEG surface concentration and layer thi...
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| Veröffentlicht in: | Langmuir 2010-05, Vol.26 (10), p.7299-7306 |
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| creator | Damodaran, Vinod Babu Fee, Conan J Ruckh, Tim Popat, Ketul C |
| description | Amine functionalized poly(ethylene glycols) (PEGs) with molecular weights 2000 and 4000 Da were covalently grafted onto carboxy modified hydrophilic Sephadex derivatives and hydrophobic polystyrene derivatives using anhydrous amine conjugation methods. Varying PEG surface concentration and layer thickness were achieved by controlling the reaction parameters and were analyzed by X-ray photoelectron spectroscopy (XPS). C−O intensities obtained from high resolution C 1s scans were correlated using the standard overlay model to study the grafting kinetics as well as conformational properties of grafted polymer chains. A detailed and systematic comparison of PEG layer thickness and distance between grafted chains with the Flory radius of surface grafted PEG resulted in valuable information regarding conformational behavior of the polymer. The influence of the nature of the solid matrix on grafting kinetics and conformational properties of the grafted polymer chain was also established from the XPS results. |
| doi_str_mv | 10.1021/la9041502 |
| format | Article |
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Varying PEG surface concentration and layer thickness were achieved by controlling the reaction parameters and were analyzed by X-ray photoelectron spectroscopy (XPS). C−O intensities obtained from high resolution C 1s scans were correlated using the standard overlay model to study the grafting kinetics as well as conformational properties of grafted polymer chains. A detailed and systematic comparison of PEG layer thickness and distance between grafted chains with the Flory radius of surface grafted PEG resulted in valuable information regarding conformational behavior of the polymer. The influence of the nature of the solid matrix on grafting kinetics and conformational properties of the grafted polymer chain was also established from the XPS results.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la9041502</identifier><identifier>PMID: 20146493</identifier><identifier>CODEN: LANGD5</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Amines - chemistry ; Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials ; Chemistry ; Colloidal state and disperse state ; Dextrans - chemistry ; Exact sciences and technology ; General and physical chemistry ; Molecular Conformation ; Molecular Weight ; Polyethylene Glycols - chemistry ; Polystyrenes - chemistry ; Spectrophotometry ; Surface physical chemistry ; Surface Properties ; X-Rays</subject><ispartof>Langmuir, 2010-05, Vol.26 (10), p.7299-7306</ispartof><rights>Copyright © 2010 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a410t-5a52ce11f2fc524e0ec8e292d6fc3eb6b0ce7d7b64220ee2cabcc1dd178079833</citedby><cites>FETCH-LOGICAL-a410t-5a52ce11f2fc524e0ec8e292d6fc3eb6b0ce7d7b64220ee2cabcc1dd178079833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/la9041502$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/la9041502$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22796054$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20146493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Damodaran, Vinod Babu</creatorcontrib><creatorcontrib>Fee, Conan J</creatorcontrib><creatorcontrib>Ruckh, Tim</creatorcontrib><creatorcontrib>Popat, Ketul C</creatorcontrib><title>Conformational Studies of Covalently Grafted Poly(ethylene glycol) on Modified Solid Matrices Using X-ray Photoelectron Spectroscopy</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>Amine functionalized poly(ethylene glycols) (PEGs) with molecular weights 2000 and 4000 Da were covalently grafted onto carboxy modified hydrophilic Sephadex derivatives and hydrophobic polystyrene derivatives using anhydrous amine conjugation methods. Varying PEG surface concentration and layer thickness were achieved by controlling the reaction parameters and were analyzed by X-ray photoelectron spectroscopy (XPS). C−O intensities obtained from high resolution C 1s scans were correlated using the standard overlay model to study the grafting kinetics as well as conformational properties of grafted polymer chains. A detailed and systematic comparison of PEG layer thickness and distance between grafted chains with the Flory radius of surface grafted PEG resulted in valuable information regarding conformational behavior of the polymer. The influence of the nature of the solid matrix on grafting kinetics and conformational properties of the grafted polymer chain was also established from the XPS results.</description><subject>Amines - chemistry</subject><subject>Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials</subject><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Dextrans - chemistry</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Molecular Conformation</subject><subject>Molecular Weight</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polystyrenes - chemistry</subject><subject>Spectrophotometry</subject><subject>Surface physical chemistry</subject><subject>Surface Properties</subject><subject>X-Rays</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0U9rFDEYBvAgil2rB7-A5CLaw2j-zWTnKIutQouFteBteCd506ZkJ2uSEebeD260a3vxlBB-efLyhJDXnH3gTPCPAXqmeMvEE7LirWBNuxb6KVkxrWSjVSePyIucbxljvVT9c3IkGFed6uWK3G3i5GLaQfFxgkC3ZbYeM42ObuIvCDiVsNCzBK6gpZcxLO-x3Cz1HOl1WEwMJzRO9CJa73wV2xi8pRdQkjc15ir76Zr-aBIs9PImlogBTUn1xnb_d5NN3C8vyTMHIeOrw3pMrk4_f998ac6_nX3dfDpvQHFWmhZaYZBzJ5xphUKGZo2iF7ZzRuLYjcygtnrslBAMURgYjeHWcr1mul9LeUze3efuU_w5Yy7DzmeDIcCEcc6DlrLlvOt0lSf30tQRc0I37JPfQVoGzoY_nQ8PnVf75pA6jzu0D_JfyRW8PQDIBoJLMBmfH53Qfcda9ejA5OE2zql-SP7Pg78BOc6XKg</recordid><startdate>20100518</startdate><enddate>20100518</enddate><creator>Damodaran, Vinod Babu</creator><creator>Fee, Conan J</creator><creator>Ruckh, Tim</creator><creator>Popat, Ketul C</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100518</creationdate><title>Conformational Studies of Covalently Grafted Poly(ethylene glycol) on Modified Solid Matrices Using X-ray Photoelectron Spectroscopy</title><author>Damodaran, Vinod Babu ; Fee, Conan J ; Ruckh, Tim ; Popat, Ketul C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a410t-5a52ce11f2fc524e0ec8e292d6fc3eb6b0ce7d7b64220ee2cabcc1dd178079833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amines - chemistry</topic><topic>Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials</topic><topic>Chemistry</topic><topic>Colloidal state and disperse state</topic><topic>Dextrans - chemistry</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Molecular Conformation</topic><topic>Molecular Weight</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polystyrenes - chemistry</topic><topic>Spectrophotometry</topic><topic>Surface physical chemistry</topic><topic>Surface Properties</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Damodaran, Vinod Babu</creatorcontrib><creatorcontrib>Fee, Conan J</creatorcontrib><creatorcontrib>Ruckh, Tim</creatorcontrib><creatorcontrib>Popat, Ketul C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Damodaran, Vinod Babu</au><au>Fee, Conan J</au><au>Ruckh, Tim</au><au>Popat, Ketul C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conformational Studies of Covalently Grafted Poly(ethylene glycol) on Modified Solid Matrices Using X-ray Photoelectron Spectroscopy</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2010-05-18</date><risdate>2010</risdate><volume>26</volume><issue>10</issue><spage>7299</spage><epage>7306</epage><pages>7299-7306</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>Amine functionalized poly(ethylene glycols) (PEGs) with molecular weights 2000 and 4000 Da were covalently grafted onto carboxy modified hydrophilic Sephadex derivatives and hydrophobic polystyrene derivatives using anhydrous amine conjugation methods. Varying PEG surface concentration and layer thickness were achieved by controlling the reaction parameters and were analyzed by X-ray photoelectron spectroscopy (XPS). C−O intensities obtained from high resolution C 1s scans were correlated using the standard overlay model to study the grafting kinetics as well as conformational properties of grafted polymer chains. A detailed and systematic comparison of PEG layer thickness and distance between grafted chains with the Flory radius of surface grafted PEG resulted in valuable information regarding conformational behavior of the polymer. The influence of the nature of the solid matrix on grafting kinetics and conformational properties of the grafted polymer chain was also established from the XPS results.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>20146493</pmid><doi>10.1021/la9041502</doi><tpages>8</tpages></addata></record> |
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| subjects | Amines - chemistry Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials Chemistry Colloidal state and disperse state Dextrans - chemistry Exact sciences and technology General and physical chemistry Molecular Conformation Molecular Weight Polyethylene Glycols - chemistry Polystyrenes - chemistry Spectrophotometry Surface physical chemistry Surface Properties X-Rays |
| title | Conformational Studies of Covalently Grafted Poly(ethylene glycol) on Modified Solid Matrices Using X-ray Photoelectron Spectroscopy |
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