Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism

Surfactant accumulates in alveolar macrophages of granulocyte-macrophage colony-stimulating factor (GM-CSF) knockout (KO) mice and pulmonary alveolar proteinosis (PAP) patients with a functional loss of GM-CSF resulting from neutralizing anti-GM-CSF antibody. Alveolar macrophages from PAP patients a...

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Veröffentlicht in:	Journal of lipid research 2010-06, Vol.51 (6), p.1325-1331
Hauptverfasser:	Baker, Anna D, Malur, Anagha, Barna, Barbara P, Ghosh, Shobha, Kavuru, Mani S, Malur, Achut G, Thomassen, Mary Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily G, Member 1 ATP-Binding Cassette Transporters - metabolism Cholesterol - metabolism Gene Knockout Techniques Lipoproteins - metabolism Lipoproteins, HDL - metabolism Liver X Receptors Lung - metabolism Macrophages, Alveolar - metabolism Mice Organ Specificity Orphan Nuclear Receptors - metabolism PPAR gamma - deficiency PPAR gamma - genetics Surface-Active Agents - metabolism
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