Mechanism of interdigestive migrating motor complex in conscious dogs
Background The migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This study was designed to clarify the mechanisms of gastric MMC (G-MMC) and intestinal MMC (I-MMC) in conscious dogs. Methods Five strain gauge transduc...
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| Veröffentlicht in: | Journal of gastroenterology 2010-05, Vol.45 (5), p.506-514 |
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| description | Background The migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This study was designed to clarify the mechanisms of gastric MMC (G-MMC) and intestinal MMC (I-MMC) in conscious dogs. Methods Five strain gauge transducers were implanted on the stomach and intestine. To investigate the correlation between luminal 5-HT and phase III contractions, gastric and duodenal juices were collected during the MMC cycle. The 5-HT concentrations in gastric and duodenal juice were measured by HPLC. To investigate whether luminal 5-HT initiates MMC, 5-HT (10⁻⁸-10⁻⁶ M, 10 ml) was administered into the duodenum 20 min after gastric phase III. To investigate the involvement of 5-HT₃ or 5-HT₄ receptors in mediating G-MMC and I-MMC, 5-HT₃ antagonists (ondansetron) or 5-HT₄ antagonists (GR 125,487) were infused for 120 min. Results Luminal administration of 5-HT (10⁻⁶ M) initiated duodenal phase II followed by G-MMC and I-MMC with a concomitant increased release of plasma motilin. The duodenal 5-HT concentration was significantly increased during phase II (59 ± 9 ng/ml) and phase III (251 ± 21 ng/ml) compared to that of phase I (29 ± 5 ng/ml). On the other hand, the 5-HT content in the stomach was not significantly changed throughout the MMC cycle. Intravenous infusion of motilin (0.3 μg/kg/h) increased the luminal 5-HT content and induced G-MMC and I-MMC. 5-HT₄ antagonists significantly inhibited both G-MMC and I-MMC, while 5-HT₃ antagonists inhibited only G-MMC. Conclusion It is suggested that the MMC cycle is mediated by a positive feedback mechanism via the interaction between motilin and 5-HT. |
| doi_str_mv | 10.1007/s00535-009-0190-z |
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This study was designed to clarify the mechanisms of gastric MMC (G-MMC) and intestinal MMC (I-MMC) in conscious dogs. Methods Five strain gauge transducers were implanted on the stomach and intestine. To investigate the correlation between luminal 5-HT and phase III contractions, gastric and duodenal juices were collected during the MMC cycle. The 5-HT concentrations in gastric and duodenal juice were measured by HPLC. To investigate whether luminal 5-HT initiates MMC, 5-HT (10⁻⁸-10⁻⁶ M, 10 ml) was administered into the duodenum 20 min after gastric phase III. To investigate the involvement of 5-HT₃ or 5-HT₄ receptors in mediating G-MMC and I-MMC, 5-HT₃ antagonists (ondansetron) or 5-HT₄ antagonists (GR 125,487) were infused for 120 min. Results Luminal administration of 5-HT (10⁻⁶ M) initiated duodenal phase II followed by G-MMC and I-MMC with a concomitant increased release of plasma motilin. The duodenal 5-HT concentration was significantly increased during phase II (59 ± 9 ng/ml) and phase III (251 ± 21 ng/ml) compared to that of phase I (29 ± 5 ng/ml). On the other hand, the 5-HT content in the stomach was not significantly changed throughout the MMC cycle. Intravenous infusion of motilin (0.3 μg/kg/h) increased the luminal 5-HT content and induced G-MMC and I-MMC. 5-HT₄ antagonists significantly inhibited both G-MMC and I-MMC, while 5-HT₃ antagonists inhibited only G-MMC. Conclusion It is suggested that the MMC cycle is mediated by a positive feedback mechanism via the interaction between motilin and 5-HT.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-009-0190-z</identifier><identifier>PMID: 20033824</identifier><language>eng</language><publisher>Japan: Japan : Springer Japan</publisher><subject>5-HT ; Abdominal Surgery ; Animals ; Colorectal Surgery ; Consciousness - physiology ; Dogs ; Duodenum - drug effects ; Duodenum - metabolism ; Duodenum - physiopathology ; Female ; Fruit juices ; Gastric MMC ; Gastroenterology ; Gastrointestinal Agents - pharmacology ; Hepatology ; Intestinal MMC ; Jejunum - drug effects ; Jejunum - metabolism ; Jejunum - physiopathology ; Medicine ; Medicine & Public Health ; motilin ; Motilin - pharmacology ; Motilin - physiology ; Mucous Membrane - drug effects ; Mucous Membrane - metabolism ; Mucous Membrane - physiopathology ; Myoelectric Complex, Migrating - drug effects ; Myoelectric Complex, Migrating - physiology ; Original Article—Alimentary Tract ; Pyloric Antrum - drug effects ; Pyloric Antrum - metabolism ; Pyloric Antrum - physiopathology ; Serotonin - pharmacology ; Serotonin - physiology ; Serotonin Agents - pharmacology ; Surgical Oncology ; Transducers, Pressure</subject><ispartof>Journal of gastroenterology, 2010-05, Vol.45 (5), p.506-514</ispartof><rights>Springer 2009</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-f8c7aebc2955fc16442347cd4409225e7e5b3df3d0dffe7d868148affccaa4a03</citedby><cites>FETCH-LOGICAL-c514t-f8c7aebc2955fc16442347cd4409225e7e5b3df3d0dffe7d868148affccaa4a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-009-0190-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-009-0190-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20033824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Hitoshi</creatorcontrib><creatorcontrib>Mochiki, Erito</creatorcontrib><creatorcontrib>Zietlow, Aaron</creatorcontrib><creatorcontrib>Ludwig, Kirk</creatorcontrib><creatorcontrib>Takahashi, Toku</creatorcontrib><title>Mechanism of interdigestive migrating motor complex in conscious dogs</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background The migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This study was designed to clarify the mechanisms of gastric MMC (G-MMC) and intestinal MMC (I-MMC) in conscious dogs. Methods Five strain gauge transducers were implanted on the stomach and intestine. To investigate the correlation between luminal 5-HT and phase III contractions, gastric and duodenal juices were collected during the MMC cycle. The 5-HT concentrations in gastric and duodenal juice were measured by HPLC. To investigate whether luminal 5-HT initiates MMC, 5-HT (10⁻⁸-10⁻⁶ M, 10 ml) was administered into the duodenum 20 min after gastric phase III. To investigate the involvement of 5-HT₃ or 5-HT₄ receptors in mediating G-MMC and I-MMC, 5-HT₃ antagonists (ondansetron) or 5-HT₄ antagonists (GR 125,487) were infused for 120 min. Results Luminal administration of 5-HT (10⁻⁶ M) initiated duodenal phase II followed by G-MMC and I-MMC with a concomitant increased release of plasma motilin. The duodenal 5-HT concentration was significantly increased during phase II (59 ± 9 ng/ml) and phase III (251 ± 21 ng/ml) compared to that of phase I (29 ± 5 ng/ml). On the other hand, the 5-HT content in the stomach was not significantly changed throughout the MMC cycle. Intravenous infusion of motilin (0.3 μg/kg/h) increased the luminal 5-HT content and induced G-MMC and I-MMC. 5-HT₄ antagonists significantly inhibited both G-MMC and I-MMC, while 5-HT₃ antagonists inhibited only G-MMC. Conclusion It is suggested that the MMC cycle is mediated by a positive feedback mechanism via the interaction between motilin and 5-HT.</description><subject>5-HT</subject><subject>Abdominal Surgery</subject><subject>Animals</subject><subject>Colorectal Surgery</subject><subject>Consciousness - physiology</subject><subject>Dogs</subject><subject>Duodenum - drug effects</subject><subject>Duodenum - metabolism</subject><subject>Duodenum - physiopathology</subject><subject>Female</subject><subject>Fruit juices</subject><subject>Gastric MMC</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Agents - pharmacology</subject><subject>Hepatology</subject><subject>Intestinal MMC</subject><subject>Jejunum - drug effects</subject><subject>Jejunum - metabolism</subject><subject>Jejunum - physiopathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>motilin</subject><subject>Motilin - pharmacology</subject><subject>Motilin - physiology</subject><subject>Mucous Membrane - drug effects</subject><subject>Mucous Membrane - metabolism</subject><subject>Mucous Membrane - physiopathology</subject><subject>Myoelectric Complex, Migrating - drug effects</subject><subject>Myoelectric Complex, Migrating - physiology</subject><subject>Original Article—Alimentary Tract</subject><subject>Pyloric Antrum - drug effects</subject><subject>Pyloric Antrum - metabolism</subject><subject>Pyloric Antrum - physiopathology</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin - physiology</subject><subject>Serotonin Agents - pharmacology</subject><subject>Surgical Oncology</subject><subject>Transducers, Pressure</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kktv1DAUhS0EosPAD2ADESxYpdzrx9hZVlV5SEUsoGvL40dwlcSDnamgvx5HKSAQQl7Yuv7O1bk-JuQpwikCyNcFQDDRAnQtYAft7T2yQV4roqP0PtlAx3mLKPkJeVTKNQAyEOohOaEAjCnKN-Tig7dfzBTL2KTQxGn22cXelzne-GaMfTZznPpmTHPKjU3jYfDfKlaPU7ExHUvjUl8ekwfBDMU_udu35OrNxefzd-3lx7fvz88uWyuQz21QVhq_t7QTIljccU4Zl9ZxDtWw8NKLPXOBOXAheOnUTiFXJgRrjeEG2Ja8Wvsecvp6rC71GIv1w2AmX71oyZhAUHW4LXnxF3mdjnmq5jRFiTsJcoFerlBvBq_jFNKcjV1a6jOJXCgquajU6T-oupwfY30HH2Kt_yHAVWBzKiX7oA85jiZ_1wh6CU6vwekanF6C07dV8-zO73E_evdL8TOpCtAVKPVq6n3-PdD_uj5fRcEkbfoci776RJdvgIpjx5H9AFQlq4g</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Nakajima, Hitoshi</creator><creator>Mochiki, Erito</creator><creator>Zietlow, Aaron</creator><creator>Ludwig, Kirk</creator><creator>Takahashi, Toku</creator><general>Japan : Springer Japan</general><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Mechanism of interdigestive migrating motor complex in conscious dogs</title><author>Nakajima, Hitoshi ; Mochiki, Erito ; Zietlow, Aaron ; Ludwig, Kirk ; Takahashi, Toku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-f8c7aebc2955fc16442347cd4409225e7e5b3df3d0dffe7d868148affccaa4a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>5-HT</topic><topic>Abdominal Surgery</topic><topic>Animals</topic><topic>Colorectal Surgery</topic><topic>Consciousness - physiology</topic><topic>Dogs</topic><topic>Duodenum - drug effects</topic><topic>Duodenum - metabolism</topic><topic>Duodenum - physiopathology</topic><topic>Female</topic><topic>Fruit juices</topic><topic>Gastric MMC</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Agents - pharmacology</topic><topic>Hepatology</topic><topic>Intestinal MMC</topic><topic>Jejunum - drug effects</topic><topic>Jejunum - metabolism</topic><topic>Jejunum - physiopathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>motilin</topic><topic>Motilin - pharmacology</topic><topic>Motilin - physiology</topic><topic>Mucous Membrane - drug effects</topic><topic>Mucous Membrane - metabolism</topic><topic>Mucous Membrane - physiopathology</topic><topic>Myoelectric Complex, Migrating - drug effects</topic><topic>Myoelectric Complex, Migrating - physiology</topic><topic>Original Article—Alimentary Tract</topic><topic>Pyloric Antrum - drug effects</topic><topic>Pyloric Antrum - metabolism</topic><topic>Pyloric Antrum - physiopathology</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin - physiology</topic><topic>Serotonin Agents - pharmacology</topic><topic>Surgical Oncology</topic><topic>Transducers, Pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakajima, Hitoshi</creatorcontrib><creatorcontrib>Mochiki, Erito</creatorcontrib><creatorcontrib>Zietlow, Aaron</creatorcontrib><creatorcontrib>Ludwig, Kirk</creatorcontrib><creatorcontrib>Takahashi, Toku</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakajima, Hitoshi</au><au>Mochiki, Erito</au><au>Zietlow, Aaron</au><au>Ludwig, Kirk</au><au>Takahashi, Toku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanism of interdigestive migrating motor complex in conscious dogs</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>45</volume><issue>5</issue><spage>506</spage><epage>514</epage><pages>506-514</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background The migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This study was designed to clarify the mechanisms of gastric MMC (G-MMC) and intestinal MMC (I-MMC) in conscious dogs. Methods Five strain gauge transducers were implanted on the stomach and intestine. To investigate the correlation between luminal 5-HT and phase III contractions, gastric and duodenal juices were collected during the MMC cycle. The 5-HT concentrations in gastric and duodenal juice were measured by HPLC. To investigate whether luminal 5-HT initiates MMC, 5-HT (10⁻⁸-10⁻⁶ M, 10 ml) was administered into the duodenum 20 min after gastric phase III. To investigate the involvement of 5-HT₃ or 5-HT₄ receptors in mediating G-MMC and I-MMC, 5-HT₃ antagonists (ondansetron) or 5-HT₄ antagonists (GR 125,487) were infused for 120 min. Results Luminal administration of 5-HT (10⁻⁶ M) initiated duodenal phase II followed by G-MMC and I-MMC with a concomitant increased release of plasma motilin. The duodenal 5-HT concentration was significantly increased during phase II (59 ± 9 ng/ml) and phase III (251 ± 21 ng/ml) compared to that of phase I (29 ± 5 ng/ml). On the other hand, the 5-HT content in the stomach was not significantly changed throughout the MMC cycle. Intravenous infusion of motilin (0.3 μg/kg/h) increased the luminal 5-HT content and induced G-MMC and I-MMC. 5-HT₄ antagonists significantly inhibited both G-MMC and I-MMC, while 5-HT₃ antagonists inhibited only G-MMC. Conclusion It is suggested that the MMC cycle is mediated by a positive feedback mechanism via the interaction between motilin and 5-HT.</abstract><cop>Japan</cop><pub>Japan : Springer Japan</pub><pmid>20033824</pmid><doi>10.1007/s00535-009-0190-z</doi><tpages>9</tpages></addata></record> |
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| subjects | 5-HT Abdominal Surgery Animals Colorectal Surgery Consciousness - physiology Dogs Duodenum - drug effects Duodenum - metabolism Duodenum - physiopathology Female Fruit juices Gastric MMC Gastroenterology Gastrointestinal Agents - pharmacology Hepatology Intestinal MMC Jejunum - drug effects Jejunum - metabolism Jejunum - physiopathology Medicine Medicine & Public Health motilin Motilin - pharmacology Motilin - physiology Mucous Membrane - drug effects Mucous Membrane - metabolism Mucous Membrane - physiopathology Myoelectric Complex, Migrating - drug effects Myoelectric Complex, Migrating - physiology Original Article—Alimentary Tract Pyloric Antrum - drug effects Pyloric Antrum - metabolism Pyloric Antrum - physiopathology Serotonin - pharmacology Serotonin - physiology Serotonin Agents - pharmacology Surgical Oncology Transducers, Pressure |
| title | Mechanism of interdigestive migrating motor complex in conscious dogs |
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