Inhibitory Effects of Herbal Extracts on Breast Cancer Resistance Protein (BCRP) and Structure-Inhibitory Potency Relationship of Isoflavonoids

The inhibition of intestinal breast cancer resistance protein (BCRP), which restricts the absorption of xenobiotics, may increase the systemic availability of its substrates. The aim of this study was to evaluate the inhibitory effects of herbal extracts and their constituents on BCRP-mediated trans...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2010-01, Vol.25 (2), p.170-179
Hauptverfasser:	Tamaki, Hirofumi, Satoh, Hiroki, Hori, Satoko, Ohtani, Hisakazu, Sawada, Yasufumi
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-binding cassette transporter G2 (ABCG2) ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - pharmacology Biological Transport breast cancer resistance protein (BCRP) Breast Neoplasms Cell Line, Tumor dietary supplement drug interactions Drug Resistance, Neoplasm Humans Isoflavones - pharmacology isoflavonoids Multidrug Resistance-Associated Proteins Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - pharmacology Plant Extracts - pharmacology Polyglutamic Acid - pharmacology Structure-Activity Relationship
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