Papuabalanols A and B, New Tannins from Balanophora papuana

Two new dehydrohexahydroxydiphenoyl (DHHDP) esters of dihydrochalcone glycosides, papuabalanols A (1) and B (2) were isolated from the ethyl acetate extract of Balanophora papuana. Their structures were elucidated on the basis of spectroscopic data and chemical evidences. Papuabalanol A (1) showed m...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2010/05/01, Vol.58(5), pp.738-741
Hauptverfasser:	Hosoya, Takahiro, Nakata, Asami, Zaima, Kazumasa, Latip, Jalifah, Din, Laily Bin, Muslim, Noramly, Morita, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-melanogenesis Balanophora papuana Balanophoraceae - chemistry Cell Line, Tumor Cell Survival - drug effects dehydroellagitannin Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Magnetic Resonance Spectroscopy Mice Molecular Structure papuabalanol Plant Components, Aerial - chemistry Plant Extracts - pharmacology Rats Tannins - chemistry Tannins - isolation & purification Tannins - therapeutic use tyrosinase inhibitory activity vasodilator Vasodilator Agents - chemistry Vasodilator Agents - isolation & purification Vasodilator Agents - pharmacology
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Zusammenfassung:	Two new dehydrohexahydroxydiphenoyl (DHHDP) esters of dihydrochalcone glycosides, papuabalanols A (1) and B (2) were isolated from the ethyl acetate extract of Balanophora papuana. Their structures were elucidated on the basis of spectroscopic data and chemical evidences. Papuabalanol A (1) showed moderate vasodilator effect on rat aorta and papuabalanol B (2) showed potent inhibition of mushroom tyrosinase and anti-melanogenesis in B16 mouse melanoma cells.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.58.738