Increased Tumor-Specific CD8+ T Cell Induction by Dendritic Cells Matured with a Clinical Grade TLR-Agonist in Combination with IFN-γ

The limited response rate of cancer patients treated with dendritic cell (DC)-based vaccines indicates that vast improvements remain necessary. In many murine tumour models it has been demonstrated that the use of innate triggers (e.g. TLR triggers) in the maturation of DC results in higher efficacy...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of immunopathology and pharmacology 2010-01, Vol.23 (1), p.35-50
Hauptverfasser:	Vanderlocht, J., Van Elssen, C.H.M.J., Senden-Gijsbers, B.L.M.G., Meek, B., Cloosen, S., Libon, C., Bos, G.M.J., Germeraad, W.T.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - immunology Cell Movement Cytokines - biosynthesis Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - physiology Humans Immunologic Memory Interferon-gamma - pharmacology Mucin-1 - immunology Neoplasms - immunology T-Lymphocytes, Helper-Inducer - immunology Toll-Like Receptors - agonists
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!