Methods for the exclusion of circoviruses and gammaherpesviruses from pigs
: The use of porcine tissues is being developed as a means to alleviate the shortage of allogeneic tissues and organs available for transplantation. To reduce the possibility of a microorganism of pigs being inadvertently transferred to the recipient of the xenograft, recommendations have been publi...
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| Veröffentlicht in: | Xenotransplantation (Københaven) 2003-07, Vol.10 (4), p.343-348 |
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| creator | Tucker, A. W. McNeilly, F. Meehan, B. Galbraith, D. McArdle, P. D. Allan, G. Patience, C. |
| description | : The use of porcine tissues is being developed as a means to alleviate the shortage of allogeneic tissues and organs available for transplantation. To reduce the possibility of a microorganism of pigs being inadvertently transferred to the recipient of the xenograft, recommendations have been published on the microbiological specifications for organ source pigs. The porcine circoviruses (PCV1 and PCV2) and porcine lymphotropic herpesviruses (PLHV1 and PLHV2) are two infectious agents of pigs which are considered to be of significance for the microbiological safety of xenotransplantation. To ensure the exclusion of these microorganisms from animals destined for use under clinical conditions, reliable breeding methodologies are required. We investigated the efficiency of established derivation procedures for the removal of PCV and PLHV. In comparison with conventionally reared pigs, caesarian and barrier derived animals showed a markedly reduced prevalence of PCVs and PLHVs. Our results indicate that the derivation of animals free of both of these microorganisms is achievable and will enhance the microbiological safety of xenotransplantation. |
| doi_str_mv | 10.1034/j.1399-3089.2003.02048.x |
| format | Article |
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We investigated the efficiency of established derivation procedures for the removal of PCV and PLHV. In comparison with conventionally reared pigs, caesarian and barrier derived animals showed a markedly reduced prevalence of PCVs and PLHVs. 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W.</creatorcontrib><creatorcontrib>McNeilly, F.</creatorcontrib><creatorcontrib>Meehan, B.</creatorcontrib><creatorcontrib>Galbraith, D.</creatorcontrib><creatorcontrib>McArdle, P. D.</creatorcontrib><creatorcontrib>Allan, G.</creatorcontrib><creatorcontrib>Patience, C.</creatorcontrib><title>Methods for the exclusion of circoviruses and gammaherpesviruses from pigs</title><title>Xenotransplantation (Københaven)</title><addtitle>Xenotransplantation</addtitle><description>: The use of porcine tissues is being developed as a means to alleviate the shortage of allogeneic tissues and organs available for transplantation. To reduce the possibility of a microorganism of pigs being inadvertently transferred to the recipient of the xenograft, recommendations have been published on the microbiological specifications for organ source pigs. The porcine circoviruses (PCV1 and PCV2) and porcine lymphotropic herpesviruses (PLHV1 and PLHV2) are two infectious agents of pigs which are considered to be of significance for the microbiological safety of xenotransplantation. To ensure the exclusion of these microorganisms from animals destined for use under clinical conditions, reliable breeding methodologies are required. We investigated the efficiency of established derivation procedures for the removal of PCV and PLHV. In comparison with conventionally reared pigs, caesarian and barrier derived animals showed a markedly reduced prevalence of PCVs and PLHVs. Our results indicate that the derivation of animals free of both of these microorganisms is achievable and will enhance the microbiological safety of xenotransplantation.</description><subject>Animals</subject><subject>Cesarean Section</subject><subject>Circoviridae Infections - epidemiology</subject><subject>Circoviridae Infections - prevention & control</subject><subject>Circoviridae Infections - transmission</subject><subject>Circovirus - genetics</subject><subject>Circovirus - isolation & purification</subject><subject>DNA, Viral - analysis</subject><subject>exclusion</subject><subject>Female</subject><subject>Gammaherpesvirinae - genetics</subject><subject>Gammaherpesvirinae - isolation & purification</subject><subject>gammaherpesviruses</subject><subject>Herpesviridae Infections - epidemiology</subject><subject>Herpesviridae Infections - prevention & control</subject><subject>Herpesviridae Infections - transmission</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>porcine circoviruses</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Sus scrofa</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Transplantation, Heterologous</subject><issn>0908-665X</issn><issn>1399-3089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PwjAYgBujEUT_gunJ2-a7dR_txcT4TRAuGrg1XdfCcKPYMoV_7yaIRz21aZ_3eZMHIRyAHwCJLud-QBjzCFDmhwDEhxAi6q8PUHf_cYi6wIB6SRJPOujEuTk0ZEzjY9QJwpTFCSVd1H9Wq5nJHdbG4tVMYbWWZe0Ks8BGY1lYaT4KWzvlsFjkeCqqSsyUXSr386ytqfCymLpTdKRF6dTZ7uyh1_u7l5tHbzB6eLq5HngyatZ7AlQmcxkAaA1ZlCdJDjpPIxJRQQOqqY7SjEkNkiRCaRbrDDRLMyEJhZwQ0kMXW-_SmvdauRWvCidVWYqFMrXjKSExpIT9CYYQhkEUtiDdgtIa56zSfGmLStgND4C3wfmct11525W3wfl3cL5uRs93O-qsUvnv4K5wA1xtgc-iVJt_i_nkbhiOmmsj8LaCwq3Uei8Q9o0nKUljPh4-8P5kPJjc9vuN7QtRwaAh</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Tucker, A. W.</creator><creator>McNeilly, F.</creator><creator>Meehan, B.</creator><creator>Galbraith, D.</creator><creator>McArdle, P. D.</creator><creator>Allan, G.</creator><creator>Patience, C.</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>Methods for the exclusion of circoviruses and gammaherpesviruses from pigs</title><author>Tucker, A. W. ; McNeilly, F. ; Meehan, B. ; Galbraith, D. ; McArdle, P. 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| subjects | Animals Cesarean Section Circoviridae Infections - epidemiology Circoviridae Infections - prevention & control Circoviridae Infections - transmission Circovirus - genetics Circovirus - isolation & purification DNA, Viral - analysis exclusion Female Gammaherpesvirinae - genetics Gammaherpesvirinae - isolation & purification gammaherpesviruses Herpesviridae Infections - epidemiology Herpesviridae Infections - prevention & control Herpesviridae Infections - transmission Infectious Disease Transmission, Vertical porcine circoviruses Pregnancy Prevalence Sus scrofa Swine Swine, Miniature Transplantation, Heterologous |
| title | Methods for the exclusion of circoviruses and gammaherpesviruses from pigs |
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