Effects of suboptimal doses of the AT1 receptor blocker, telmisartan, with the angiotensin-converting enzyme inhibitor, ramipril, on cerebral arterioles in spontaneously hypertensive rat

OBJECTIVEAntihypertensive treatment with standard clinical doses of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) reverses cerebral arteriolar remodeling, thus restoring dilatation and the lower limit of cerebral blood flow (CBF) autoregulation (LL CBF A...

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Veröffentlicht in:	Journal of hypertension 2010-07, Vol.28 (7), p.1566-1573
Hauptverfasser:	Dupuis, François, Vincent, Jean-Martin, Limiñana, Patrick, Chillon, Jean-Marc, Capdeville-Atkinson, Christine, Atkinson, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive agents Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Arterioles - drug effects Arterioles - physiopathology Benzimidazoles - administration & dosage Benzimidazoles - pharmacology Benzoates - administration & dosage Benzoates - pharmacology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cardiovascular system Cerebrovascular Circulation - drug effects Drug Therapy, Combination Hypertension - drug therapy Hypertension - physiopathology Male Medical sciences Pharmacology. Drug treatments Ramipril - administration & dosage Ramipril - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Telmisartan
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