Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease
Recently, a single nucleotide polymorphism (SNP, A → G) in intron 8 of UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD). Here, we aimed to investigate whether an association exists between the UBQ-8i polymorphism...
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| Veröffentlicht in: | Neuroscience letters 2010-05, Vol.475 (2), p.108-109 |
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| creator | Chuo, Liang-Jen Wu, Shwu-Tzy Chang, Hong-I. Kuo, Yu-Min |
| description | Recently, a single nucleotide polymorphism (SNP, A
→
G) in intron 8 of
UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD). Here, we aimed to investigate whether an association exists between the UBQ-8i polymorphism and AD in Taiwan Chinese. Initially, we included 100 late-onset AD patients and 100 gender- and age-matched non-demented (ND) control participants. The UBQ-8i polymorphism site was successfully determined in 91 AD and 96 ND individuals using the dye terminator nucleotide sequencing technique. Among the 187 participants, we did not detect any subject carrying the G allele. This finding is in agreement with the report listed in the NCBI SNP Reference Assembly, which states that |
| doi_str_mv | 10.1016/j.neulet.2010.03.061 |
| format | Article |
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→
G) in intron 8 of
UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD). Here, we aimed to investigate whether an association exists between the UBQ-8i polymorphism and AD in Taiwan Chinese. Initially, we included 100 late-onset AD patients and 100 gender- and age-matched non-demented (ND) control participants. The UBQ-8i polymorphism site was successfully determined in 91 AD and 96 ND individuals using the dye terminator nucleotide sequencing technique. Among the 187 participants, we did not detect any subject carrying the G allele. This finding is in agreement with the report listed in the NCBI SNP Reference Assembly, which states that <1% of Asians carry this SNP. The
APOE ɛ4 allele, an established AD genetic risk factor, was overrepresented in the AD cohort. We conclude from these results that the UBQ-8i polymorphism of the
UBQLN1 gene is extremely rare in Taiwan Chinese and unlikely to play a significant role in the risk of AD in Taiwan Chinese.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2010.03.061</identifier><identifier>PMID: 20350585</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - genetics ; Alzheimer's disease ; Apolipoprotein E4 - genetics ; Asian Continental Ancestry Group ; Biological and medical sciences ; Carrier Proteins - genetics ; Cell Cycle Proteins - genetics ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Medical sciences ; Neurology ; Polymorphism ; Polymorphism, Single Nucleotide ; Taiwan ; Ubiquilin 1 ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2010-05, Vol.475 (2), p.108-109</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-3c734e824f7a7ea7646f0d022166f70967ba92e7870c8abe708f719235fe68f23</citedby><cites>FETCH-LOGICAL-c391t-3c734e824f7a7ea7646f0d022166f70967ba92e7870c8abe708f719235fe68f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2010.03.061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23032729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20350585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chuo, Liang-Jen</creatorcontrib><creatorcontrib>Wu, Shwu-Tzy</creatorcontrib><creatorcontrib>Chang, Hong-I.</creatorcontrib><creatorcontrib>Kuo, Yu-Min</creatorcontrib><title>Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Recently, a single nucleotide polymorphism (SNP, A
→
G) in intron 8 of
UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD). Here, we aimed to investigate whether an association exists between the UBQ-8i polymorphism and AD in Taiwan Chinese. Initially, we included 100 late-onset AD patients and 100 gender- and age-matched non-demented (ND) control participants. The UBQ-8i polymorphism site was successfully determined in 91 AD and 96 ND individuals using the dye terminator nucleotide sequencing technique. Among the 187 participants, we did not detect any subject carrying the G allele. This finding is in agreement with the report listed in the NCBI SNP Reference Assembly, which states that <1% of Asians carry this SNP. The
APOE ɛ4 allele, an established AD genetic risk factor, was overrepresented in the AD cohort. We conclude from these results that the UBQ-8i polymorphism of the
UBQLN1 gene is extremely rare in Taiwan Chinese and unlikely to play a significant role in the risk of AD in Taiwan Chinese.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Taiwan</subject><subject>Ubiquilin 1</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi0EoqHwDxDyBZUeNoztXdt7QWqj0laKipDas-V4x6yj_Qj2hjb99ThKgBunkV4978zoIeQ9gzkDJj-v5wNuO5zmHHIEYg6SvSAzphUvVK34SzIDAWUh6hJOyJuU1gBQsap8TU44iAoqXc3Ij6unKWKP3Y5GG5GGwYUGB4d09HRqkT5cfl_eMboZu10_xk0bUk8_5bDQ4TzT9N6GRzvQRRsGTEgfw9TSi-65xdBjPEu0CQltwrfklbddwnfHeUoevl7dL26K5bfr28XFsnCiZlMhnBIlal56ZRVaJUvpoQHOmZReQS3VytYclVbgtF2hAu0Vq7moPErtuTglZ4e9mzj-3GKaTB-Sw66zA47bZJQQZa1lxTJZHkgXx5QierOJobdxZxiYvWGzNgfDZm_YgDDZcK59OB7Yrnps_pb-KM3AxyNgk7OdjzYrTf84AYIrXmfuy4HDrONXwGiSC3vzTYjoJtOM4f-f_AYF7Zm7</recordid><startdate>20100514</startdate><enddate>20100514</enddate><creator>Chuo, Liang-Jen</creator><creator>Wu, Shwu-Tzy</creator><creator>Chang, Hong-I.</creator><creator>Kuo, Yu-Min</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100514</creationdate><title>Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease</title><author>Chuo, Liang-Jen ; Wu, Shwu-Tzy ; Chang, Hong-I. ; Kuo, Yu-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-3c734e824f7a7ea7646f0d022166f70967ba92e7870c8abe708f719235fe68f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Taiwan</topic><topic>Ubiquilin 1</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chuo, Liang-Jen</creatorcontrib><creatorcontrib>Wu, Shwu-Tzy</creatorcontrib><creatorcontrib>Chang, Hong-I.</creatorcontrib><creatorcontrib>Kuo, Yu-Min</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chuo, Liang-Jen</au><au>Wu, Shwu-Tzy</au><au>Chang, Hong-I.</au><au>Kuo, Yu-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2010-05-14</date><risdate>2010</risdate><volume>475</volume><issue>2</issue><spage>108</spage><epage>109</epage><pages>108-109</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Recently, a single nucleotide polymorphism (SNP, A
→
G) in intron 8 of
UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD). Here, we aimed to investigate whether an association exists between the UBQ-8i polymorphism and AD in Taiwan Chinese. Initially, we included 100 late-onset AD patients and 100 gender- and age-matched non-demented (ND) control participants. The UBQ-8i polymorphism site was successfully determined in 91 AD and 96 ND individuals using the dye terminator nucleotide sequencing technique. Among the 187 participants, we did not detect any subject carrying the G allele. This finding is in agreement with the report listed in the NCBI SNP Reference Assembly, which states that <1% of Asians carry this SNP. The
APOE ɛ4 allele, an established AD genetic risk factor, was overrepresented in the AD cohort. We conclude from these results that the UBQ-8i polymorphism of the
UBQLN1 gene is extremely rare in Taiwan Chinese and unlikely to play a significant role in the risk of AD in Taiwan Chinese.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20350585</pmid><doi>10.1016/j.neulet.2010.03.061</doi><tpages>2</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2010-05, Vol.475 (2), p.108-109 |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 - genetics Asian Continental Ancestry Group Biological and medical sciences Carrier Proteins - genetics Cell Cycle Proteins - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Fundamental and applied biological sciences. Psychology Genetic Association Studies Genetic Predisposition to Disease Humans Male Medical sciences Neurology Polymorphism Polymorphism, Single Nucleotide Taiwan Ubiquilin 1 Vertebrates: nervous system and sense organs |
| title | Extremely rare incidence of the UBQLN1 polymorphism (UBQ-8i) in Taiwan Chinese with Alzheimer's disease |
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