Overproduction of gamma-linolenic and eicosapentaenoic acids by algae
The pharmaceutical interest and limited availability of gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA) prompted the search for genetic means for increasing the production of these fatty acids from algal sources. Cell lines of Spirulina platensis and Porphyridium cruentum resistant to the...
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| Veröffentlicht in: | Plant physiology (Bethesda) 1992-02, Vol.98 (2), p.569-572 |
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| container_title | Plant physiology (Bethesda) |
| container_volume | 98 |
| creator | Cohen, Z. (Ben-Gurion University of the Negev, Israel) Didi, S Heimer, Y.M |
| description | The pharmaceutical interest and limited availability of gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA) prompted the search for genetic means for increasing the production of these fatty acids from algal sources. Cell lines of Spirulina platensis and Porphyridium cruentum resistant to the growth inhibition of the herbicide Sandoz 9785 were selected by serial transfers of the culture in the presence of increasing concentrations of the herbicide. The resistant cell lines of S. platensis overproduced GLA and those of P. cruentum overproduced EPA and were stable for at least 50 generations in the absence of the inhibitor |
| doi_str_mv | 10.1104/pp.98.2.569 |
| format | Article |
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(Ben-Gurion University of the Negev, Israel) ; Didi, S ; Heimer, Y.M</creator><creatorcontrib>Cohen, Z. (Ben-Gurion University of the Negev, Israel) ; Didi, S ; Heimer, Y.M</creatorcontrib><description>The pharmaceutical interest and limited availability of gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA) prompted the search for genetic means for increasing the production of these fatty acids from algal sources. Cell lines of Spirulina platensis and Porphyridium cruentum resistant to the growth inhibition of the herbicide Sandoz 9785 were selected by serial transfers of the culture in the presence of increasing concentrations of the herbicide. The resistant cell lines of S. platensis overproduced GLA and those of P. cruentum overproduced EPA and were stable for at least 50 generations in the absence of the inhibitor</description><identifier>ISSN: 0032-0889</identifier><identifier>EISSN: 1532-2548</identifier><identifier>DOI: 10.1104/pp.98.2.569</identifier><identifier>PMID: 16668678</identifier><identifier>CODEN: PPHYA5</identifier><language>eng</language><publisher>Rockville, MD: American Society of Plant Physiologists</publisher><subject>ACIDE GRAS INSATURE ; ACIDE LINOLENIQUE ; ACIDO LINOLENICO ; ACIDOS GRASOS INSATURADOS ; ALGAE ; AMELIORATION DES PLANTES ; Biological and medical sciences ; BIOSINTESIS ; BIOSYNTHESE ; Biotechnology ; Cell growth ; Cell lines ; Chemical desaturation ; CULTIVO DE CELULAS ; CULTURE DE CELLULE ; Cultured cells ; CYANOPHYTA ; Fatty acids ; FITOMEJORAMIENTO ; Fundamental and applied biological sciences. Psychology ; GENETICA ; GENETIQUE ; Health. Pharmaceutical industry ; HERBICIDAS ; HERBICIDE ; Herbicide resistance ; Herbicides ; Industrial applications and implications. Economical aspects ; Marine ; Other active biomolecules ; Overproduction ; Plants ; Porphyridium cruentum ; Production of active biomolecules ; RESISTANCE AUX PRODUITS CHIMIQUES ; RESISTENCIA QUIMICA ; Rhodophyta ; SELECCION ; SELECTION ; Spirulina platensis ; VARIEDADES DE ALTO RENDIMIENTO ; VARIETE A HAUT RENDEMENT</subject><ispartof>Plant physiology (Bethesda), 1992-02, Vol.98 (2), p.569-572</ispartof><rights>Copyright 1992 American Society of Plant Physiologists</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d07f047d59dfb4ccad70ec827ebf4a0d41e84211ec82ae0483670452e7577aa23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4274128$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4274128$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5266615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16668678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Z. (Ben-Gurion University of the Negev, Israel)</creatorcontrib><creatorcontrib>Didi, S</creatorcontrib><creatorcontrib>Heimer, Y.M</creatorcontrib><title>Overproduction of gamma-linolenic and eicosapentaenoic acids by algae</title><title>Plant physiology (Bethesda)</title><addtitle>Plant Physiol</addtitle><description>The pharmaceutical interest and limited availability of gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA) prompted the search for genetic means for increasing the production of these fatty acids from algal sources. Cell lines of Spirulina platensis and Porphyridium cruentum resistant to the growth inhibition of the herbicide Sandoz 9785 were selected by serial transfers of the culture in the presence of increasing concentrations of the herbicide. The resistant cell lines of S. platensis overproduced GLA and those of P. cruentum overproduced EPA and were stable for at least 50 generations in the absence of the inhibitor</description><subject>ACIDE GRAS INSATURE</subject><subject>ACIDE LINOLENIQUE</subject><subject>ACIDO LINOLENICO</subject><subject>ACIDOS GRASOS INSATURADOS</subject><subject>ALGAE</subject><subject>AMELIORATION DES PLANTES</subject><subject>Biological and medical sciences</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>Biotechnology</subject><subject>Cell growth</subject><subject>Cell lines</subject><subject>Chemical desaturation</subject><subject>CULTIVO DE CELULAS</subject><subject>CULTURE DE CELLULE</subject><subject>Cultured cells</subject><subject>CYANOPHYTA</subject><subject>Fatty acids</subject><subject>FITOMEJORAMIENTO</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENETICA</subject><subject>GENETIQUE</subject><subject>Health. Pharmaceutical industry</subject><subject>HERBICIDAS</subject><subject>HERBICIDE</subject><subject>Herbicide resistance</subject><subject>Herbicides</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Marine</subject><subject>Other active biomolecules</subject><subject>Overproduction</subject><subject>Plants</subject><subject>Porphyridium cruentum</subject><subject>Production of active biomolecules</subject><subject>RESISTANCE AUX PRODUITS CHIMIQUES</subject><subject>RESISTENCIA QUIMICA</subject><subject>Rhodophyta</subject><subject>SELECCION</subject><subject>SELECTION</subject><subject>Spirulina platensis</subject><subject>VARIEDADES DE ALTO RENDIMIENTO</subject><subject>VARIETE A HAUT RENDEMENT</subject><issn>0032-0889</issn><issn>1532-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNp90c9r2zAUB3AxOpY022m3UYoPpTsUZ_plST6O0m6FQg9bzuJFeg4OtuVKziD__RQS0ltPEu99-CK-IuQro0vGqPwxjsvaLPmyUvUHMmeV4CWvpLkgc0rznRpTz8hlSltKKRNMfiIzppQySps5eXj5h3GMwe_c1IahCE2xgb6HsmuH0OHQugIGX2DrQoIRhwlwCIeha30q1vsCug3gZ_KxgS7hl9O5IKvHh7_3v8vnl19P9z-fSye5mEpPdUOl9lXtm7V0Drym6AzXuG4kUC8ZGskZO8wAqTRCaSorjrrSGoCLBfl-zM0vft1hmmzfJoddBwOGXbJaCFlrpmiWt-9KpipjlNAZ3h2hiyGliI0dY9tD3FtG7aFfO462Npbb3G_W16fY3bpH_2ZPhWZwcwKQHHRNhMG16ewqnmH-ogW5OrJtmkI8ryXXkvFDyrfjuoFgYRNzwupPzYySQon_to2TwQ</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>Cohen, Z. 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(Ben-Gurion University of the Negev, Israel) ; Didi, S ; Heimer, Y.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d07f047d59dfb4ccad70ec827ebf4a0d41e84211ec82ae0483670452e7577aa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>ACIDE GRAS INSATURE</topic><topic>ACIDE LINOLENIQUE</topic><topic>ACIDO LINOLENICO</topic><topic>ACIDOS GRASOS INSATURADOS</topic><topic>ALGAE</topic><topic>AMELIORATION DES PLANTES</topic><topic>Biological and medical sciences</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>Biotechnology</topic><topic>Cell growth</topic><topic>Cell lines</topic><topic>Chemical desaturation</topic><topic>CULTIVO DE CELULAS</topic><topic>CULTURE DE CELLULE</topic><topic>Cultured cells</topic><topic>CYANOPHYTA</topic><topic>Fatty acids</topic><topic>FITOMEJORAMIENTO</topic><topic>Fundamental and applied biological sciences. 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(Ben-Gurion University of the Negev, Israel)</au><au>Didi, S</au><au>Heimer, Y.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overproduction of gamma-linolenic and eicosapentaenoic acids by algae</atitle><jtitle>Plant physiology (Bethesda)</jtitle><addtitle>Plant Physiol</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>98</volume><issue>2</issue><spage>569</spage><epage>572</epage><pages>569-572</pages><issn>0032-0889</issn><eissn>1532-2548</eissn><coden>PPHYA5</coden><abstract>The pharmaceutical interest and limited availability of gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA) prompted the search for genetic means for increasing the production of these fatty acids from algal sources. Cell lines of Spirulina platensis and Porphyridium cruentum resistant to the growth inhibition of the herbicide Sandoz 9785 were selected by serial transfers of the culture in the presence of increasing concentrations of the herbicide. The resistant cell lines of S. platensis overproduced GLA and those of P. cruentum overproduced EPA and were stable for at least 50 generations in the absence of the inhibitor</abstract><cop>Rockville, MD</cop><pub>American Society of Plant Physiologists</pub><pmid>16668678</pmid><doi>10.1104/pp.98.2.569</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0032-0889 |
| ispartof | Plant physiology (Bethesda), 1992-02, Vol.98 (2), p.569-572 |
| issn | 0032-0889 1532-2548 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733497160 |
| source | JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ACIDE GRAS INSATURE ACIDE LINOLENIQUE ACIDO LINOLENICO ACIDOS GRASOS INSATURADOS ALGAE AMELIORATION DES PLANTES Biological and medical sciences BIOSINTESIS BIOSYNTHESE Biotechnology Cell growth Cell lines Chemical desaturation CULTIVO DE CELULAS CULTURE DE CELLULE Cultured cells CYANOPHYTA Fatty acids FITOMEJORAMIENTO Fundamental and applied biological sciences. Psychology GENETICA GENETIQUE Health. Pharmaceutical industry HERBICIDAS HERBICIDE Herbicide resistance Herbicides Industrial applications and implications. Economical aspects Marine Other active biomolecules Overproduction Plants Porphyridium cruentum Production of active biomolecules RESISTANCE AUX PRODUITS CHIMIQUES RESISTENCIA QUIMICA Rhodophyta SELECCION SELECTION Spirulina platensis VARIEDADES DE ALTO RENDIMIENTO VARIETE A HAUT RENDEMENT |
| title | Overproduction of gamma-linolenic and eicosapentaenoic acids by algae |
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