Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices
We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species. Estimated first and second phase insulin responses (1stPH(S) and 2ndPH(S)) were...
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| Veröffentlicht in: | European journal of endocrinology 2003-06, Vol.148 (6), p.641-647 |
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| container_title | European journal of endocrinology |
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| creator | CHIU, Ken C CHUANG, Lee-Ming CHU, Audrey YOON, Carol WANG, Max |
| description | We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species.
Estimated first and second phase insulin responses (1stPH(S) and 2ndPH(S)) were estimated from oral glucose tolerance tests in 78 glucose tolerant subjects. Among these subjects, first and second phase insulin responses (1stIR and 2ndIR) were measured in 60 subjects. The I27L genotypes were determined from genomic DNA. We also reviewed the published peptide sequence data on this polymorphism.
The estimated beta cell indices correlated well with the measured indices. Although the impact of this polymorphism was noted in the measured indices (P |
| doi_str_mv | 10.1530/eje.0.1480641 |
| format | Article |
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Estimated first and second phase insulin responses (1stPH(S) and 2ndPH(S)) were estimated from oral glucose tolerance tests in 78 glucose tolerant subjects. Among these subjects, first and second phase insulin responses (1stIR and 2ndIR) were measured in 60 subjects. The I27L genotypes were determined from genomic DNA. We also reviewed the published peptide sequence data on this polymorphism.
The estimated beta cell indices correlated well with the measured indices. Although the impact of this polymorphism was noted in the measured indices (P<0.01 for 1stIR and P=0.04 for 2ndIR) from 60 subjects, the differences in the estimated indices were only noted in the extended sample set with 78 subjects (P=0.05 for 1stPH(S) and P=0.04 for 2ndPH(S)). This polymorphism occurs in the dimerization domain, which is completely conserved within human, rat, mouse and hamster. This amino acid is also conserved in chicken and zebrafish, but not in the frog. This conservation suggests a possible biological importance of this amino acid.
By increasing the sample size, we demonstrated the role of the I27L polymorphism in the pathogenesis of type 2 diabetes by using estimated beta cell indices. The conservation among species suggests a possible biological importance of this amino acid. Analysis of the published data confirms a modest role of this polymorphism in type 2 diabetes.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1480641</identifier><identifier>PMID: 12773136</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Adult ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Conserved Sequence ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; DNA-Binding Proteins ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Hepatocyte Nuclear Factor 1 ; Hepatocyte Nuclear Factor 1-alpha ; Hepatocyte Nuclear Factor 1-beta ; Humans ; Hyperglycemia - genetics ; Insulin - blood ; Islets of Langerhans - physiology ; Male ; Medical sciences ; Molecular Sequence Data ; Nuclear Proteins ; Polymorphism, Single Nucleotide ; Transcription Factors - genetics ; Zebrafish Proteins</subject><ispartof>European journal of endocrinology, 2003-06, Vol.148 (6), p.641-647</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2341-52cf440904e0c3a09157b4ef68b26466f6580b86b3be7c3d3566b1b4555e3d063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14865323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12773136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHIU, Ken C</creatorcontrib><creatorcontrib>CHUANG, Lee-Ming</creatorcontrib><creatorcontrib>CHU, Audrey</creatorcontrib><creatorcontrib>YOON, Carol</creatorcontrib><creatorcontrib>WANG, Max</creatorcontrib><title>Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species.
Estimated first and second phase insulin responses (1stPH(S) and 2ndPH(S)) were estimated from oral glucose tolerance tests in 78 glucose tolerant subjects. Among these subjects, first and second phase insulin responses (1stIR and 2ndIR) were measured in 60 subjects. The I27L genotypes were determined from genomic DNA. We also reviewed the published peptide sequence data on this polymorphism.
The estimated beta cell indices correlated well with the measured indices. Although the impact of this polymorphism was noted in the measured indices (P<0.01 for 1stIR and P=0.04 for 2ndIR) from 60 subjects, the differences in the estimated indices were only noted in the extended sample set with 78 subjects (P=0.05 for 1stPH(S) and P=0.04 for 2ndPH(S)). This polymorphism occurs in the dimerization domain, which is completely conserved within human, rat, mouse and hamster. This amino acid is also conserved in chicken and zebrafish, but not in the frog. This conservation suggests a possible biological importance of this amino acid.
By increasing the sample size, we demonstrated the role of the I27L polymorphism in the pathogenesis of type 2 diabetes by using estimated beta cell indices. The conservation among species suggests a possible biological importance of this amino acid. Analysis of the published data confirms a modest role of this polymorphism in type 2 diabetes.</description><subject>Adult</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conserved Sequence</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA-Binding Proteins</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Hepatocyte Nuclear Factor 1</subject><subject>Hepatocyte Nuclear Factor 1-alpha</subject><subject>Hepatocyte Nuclear Factor 1-beta</subject><subject>Humans</subject><subject>Hyperglycemia - genetics</subject><subject>Insulin - blood</subject><subject>Islets of Langerhans - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Transcription Factors - genetics</subject><subject>Zebrafish Proteins</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMoun4cvUoueqtOOknaPcriFyx4UfBWknTKVtqmJu1hf4D_28iueMo7M09eZl7GLgXcCoVwR590m6QsQUtxwBZCFstMl_hxyBZQgsyklnjCTmP8BBBJwzE7EXlRoEC9YN8r348mtNEP3Dd82hBvU8NNf9VLXqz56Ltt78O4aWP_N9jQaCbvthPxYXYdmcCb9M-HTJhu3BieHClObW8mqrkZat6TiXNIhaXJcEddx9uhbh3Fc3bUmC7Sxf49Y--PD2-r52z9-vSyul9nLkcpMpW7RkpYgiRwaGApVGElNbq0uZZaN1qVYEtt0VLhsEaltRVWKqUIa9B4xm52vmPwX3Parurb-LuIGcjPsSoQZZkDJDDbgS74GAM11RjSJWFbCah-c69S7lWSu9wTf7U3nm1P9T-9DzoB13vARGe6JpjBtfGfk6VWmCP-APAZi2Q</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>CHIU, Ken C</creator><creator>CHUANG, Lee-Ming</creator><creator>CHU, Audrey</creator><creator>YOON, Carol</creator><creator>WANG, Max</creator><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices</title><author>CHIU, Ken C ; CHUANG, Lee-Ming ; CHU, Audrey ; YOON, Carol ; WANG, Max</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2341-52cf440904e0c3a09157b4ef68b26466f6580b86b3be7c3d3566b1b4555e3d063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conserved Sequence</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA-Binding Proteins</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Hepatocyte Nuclear Factor 1</topic><topic>Hepatocyte Nuclear Factor 1-alpha</topic><topic>Hepatocyte Nuclear Factor 1-beta</topic><topic>Humans</topic><topic>Hyperglycemia - genetics</topic><topic>Insulin - blood</topic><topic>Islets of Langerhans - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Transcription Factors - genetics</topic><topic>Zebrafish Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIU, Ken C</creatorcontrib><creatorcontrib>CHUANG, Lee-Ming</creatorcontrib><creatorcontrib>CHU, Audrey</creatorcontrib><creatorcontrib>YOON, Carol</creatorcontrib><creatorcontrib>WANG, Max</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIU, Ken C</au><au>CHUANG, Lee-Ming</au><au>CHU, Audrey</au><au>YOON, Carol</au><au>WANG, Max</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2003-06</date><risdate>2003</risdate><volume>148</volume><issue>6</issue><spage>641</spage><epage>647</epage><pages>641-647</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species.
Estimated first and second phase insulin responses (1stPH(S) and 2ndPH(S)) were estimated from oral glucose tolerance tests in 78 glucose tolerant subjects. Among these subjects, first and second phase insulin responses (1stIR and 2ndIR) were measured in 60 subjects. The I27L genotypes were determined from genomic DNA. We also reviewed the published peptide sequence data on this polymorphism.
The estimated beta cell indices correlated well with the measured indices. Although the impact of this polymorphism was noted in the measured indices (P<0.01 for 1stIR and P=0.04 for 2ndIR) from 60 subjects, the differences in the estimated indices were only noted in the extended sample set with 78 subjects (P=0.05 for 1stPH(S) and P=0.04 for 2ndPH(S)). This polymorphism occurs in the dimerization domain, which is completely conserved within human, rat, mouse and hamster. This amino acid is also conserved in chicken and zebrafish, but not in the frog. This conservation suggests a possible biological importance of this amino acid.
By increasing the sample size, we demonstrated the role of the I27L polymorphism in the pathogenesis of type 2 diabetes by using estimated beta cell indices. The conservation among species suggests a possible biological importance of this amino acid. Analysis of the published data confirms a modest role of this polymorphism in type 2 diabetes.</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>12773136</pmid><doi>10.1530/eje.0.1480641</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Amino Acid Sequence Animals Biological and medical sciences Conserved Sequence Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance DNA-Binding Proteins Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta Humans Hyperglycemia - genetics Insulin - blood Islets of Langerhans - physiology Male Medical sciences Molecular Sequence Data Nuclear Proteins Polymorphism, Single Nucleotide Transcription Factors - genetics Zebrafish Proteins |
| title | Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices |
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