Dibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells

An elevated level of cyclic AMP (cAMP) within cells activates gene expression through the cAMP-PKA-CREB pathway. Among the CREB target genes, some immediate early genes exist that are responsive to cAMP including the nur77 and c-fos genes. Treatment with dibutyryl-cAMP (dbcAMP) as well as nerve grow...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of biochemistry (Tokyo) 2010-07, Vol.148 (1), p.93-101
Hauptverfasser:	Maruoka, Hiroki, Sasaya, Harue, Shimamura, Yuichi, Nakatani, Yosuke, Shimoke, Koji, Ikeuchi, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Bucladesine - pharmacology cAMP Cell Growth Processes - drug effects Cyclic AMP-Dependent Protein Kinases - metabolism Differentiation Histones - metabolism immediate early gene local chromatin structure Neurites - drug effects Neurites - metabolism Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism PC12 cell PC12 Cells Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins c-fos - genetics Rats Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!