Conversion of (3S,4R)-Tetrahydrodaidzein to (3S)-Equol by THD Reductase: Proposed Mechanism Involving a Radical Intermediate

To elucidate the mechanism of (3S)-equol biosynthesis, (2,3,4-d 3)-trans-THD was synthesized and converted to (3S)-equol by THD reductase in Eggerthella strain Julong 732. The position of the deuterium atoms in (3S)-equol was determined by 1H NMR and 2H NMR spectroscopy, and the product was identifi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2010-07, Vol.49 (26), p.5582-5587
Hauptverfasser:	Kim, Mihyang, Marsh, E. Neil G, Kim, Soo-Un, Han, Jaehong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria, Anaerobic - metabolism Deuterium Equol Free Radicals - metabolism Isoflavones - biosynthesis Isoflavones - metabolism Magnetic Resonance Spectroscopy Molecular Conformation Organic Chemistry Phenomena Oxidoreductases - metabolism Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!