Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes

The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi‐billion dollar drug, simvastatin (Zocor™). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels‐A...

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Veröffentlicht in:	Biopolymers 2010-09, Vol.93 (9), p.755-763
Hauptverfasser:	Campbell, Chantel D., Vederas, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	biosynthesis Cytochalasins - biosynthesis Cytochalasins - chemistry Diels Alderase enzyme Lactones - chemistry Lactones - metabolism Lovastatin - analogs & derivatives Lovastatin - biosynthesis Lovastatin - chemistry natural product polyketide Polyketide Synthases - metabolism Pyrrolidinones - chemistry Pyrrolidinones - metabolism RNA, Catalytic - metabolism Simvastatin - chemical synthesis Simvastatin - chemistry Tetrahydronaphthalenes - chemistry Tetrahydronaphthalenes - metabolism
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