Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

Neurotrophins are growth factors that are important in neuronal development and survival as well as synapse formation and plasticity. Many of the effects of neurotrophins are mediated by changes in protein expression as a result of altered transcription or translation. To determine whether neurotrop...

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Veröffentlicht in:	Biochemical journal 2010-06, Vol.428 (2), p.281-291
Hauptverfasser:	Remenyi, Judit, Hunter, Christopher J, Cole, Christian, Ando, Hideaki, Impey, Soren, Monk, Claire E, Martin, Kirsty J, Barton, Geoffrey J, Hutvagner, Gyorgy, Arthur, J Simon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Benzamides - pharmacology Blotting, Northern Brain-Derived Neurotrophic Factor - pharmacology Cells, Cultured Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP Response Element-Binding Protein - physiology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic MicroRNAs - genetics Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - physiology Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - physiology Molecular Sequence Data Neurons - metabolism Neurons - microbiology Nucleic Acid Amplification Techniques Phosphorylation - genetics Phosphorylation - physiology Polymerase Chain Reaction Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - physiology Sequence Homology, Nucleic Acid
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