Muscarinic antagonist effects on executive control of attention
Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo i...
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Veröffentlicht in: | The international journal of neuropsychopharmacology 2009-11, Vol.12 (10), p.1307-1317 |
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creator | Thienel, Renate Kellermann, Thilo Schall, Ulrich Voss, Bianca Reske, Martina Halfter, Sarah Sheldrick, Abigail J. Radenbach, Katrin Habel, Ute Jon Shah, Nadim Kircher, Tilo |
description | Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic resonance scanner. Neurocognitive measures included verbal learning, verbal memory, verbal fluency, trail making, digit span, a continuous performance task and a planning task (Tower of London). When compared to placebo, scopolamine increased reaction times for conflicting stimulus processing, together with decreasing brain activation in the anterior cingulate cortex (a brain region involved in conflict processing) suggestive of a muscarinic antagonist effect on executive control of attention. Contrary to the notion of a predominantly right-hemispheric lateralization of cognitive processes associated with orienting attention, scopolamine reduced brain activity in left superior and left middle frontal brain areas. Our neuropsychological test data revealed a selective effect of scopolamine on verbal learning and memory while other cognitive domains, such as planning and working memory, were unaffected. These findings are consistent with muscarinic modulation of dopaminergic neurotransmission in frontal attention networks when processing conflicting information. |
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We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic resonance scanner. Neurocognitive measures included verbal learning, verbal memory, verbal fluency, trail making, digit span, a continuous performance task and a planning task (Tower of London). When compared to placebo, scopolamine increased reaction times for conflicting stimulus processing, together with decreasing brain activation in the anterior cingulate cortex (a brain region involved in conflict processing) suggestive of a muscarinic antagonist effect on executive control of attention. Contrary to the notion of a predominantly right-hemispheric lateralization of cognitive processes associated with orienting attention, scopolamine reduced brain activity in left superior and left middle frontal brain areas. Our neuropsychological test data revealed a selective effect of scopolamine on verbal learning and memory while other cognitive domains, such as planning and working memory, were unaffected. These findings are consistent with muscarinic modulation of dopaminergic neurotransmission in frontal attention networks when processing conflicting information.</description><identifier>ISSN: 1461-1457</identifier><identifier>EISSN: 1469-5111</identifier><identifier>DOI: 10.1017/S146114570999068X</identifier><identifier>PMID: 19793402</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Attention - drug effects ; Attention - physiology ; Cross-Over Studies ; Executive Function - drug effects ; Executive Function - physiology ; Humans ; Male ; Muscarinic Antagonists - pharmacology ; Psychomotor Performance - drug effects ; Psychomotor Performance - physiology ; Reaction Time - drug effects ; Reaction Time - physiology ; Scopolamine Hydrobromide - pharmacology ; Single-Blind Method ; Young Adult</subject><ispartof>The international journal of neuropsychopharmacology, 2009-11, Vol.12 (10), p.1307-1317</ispartof><rights>Copyright © CINP 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-f6d17d4a4c3b4ff4a06ccd02db3185268c6f87f70567be48a9fbf3fb05c09a073</citedby><cites>FETCH-LOGICAL-c559t-f6d17d4a4c3b4ff4a06ccd02db3185268c6f87f70567be48a9fbf3fb05c09a073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19793402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thienel, Renate</creatorcontrib><creatorcontrib>Kellermann, Thilo</creatorcontrib><creatorcontrib>Schall, Ulrich</creatorcontrib><creatorcontrib>Voss, Bianca</creatorcontrib><creatorcontrib>Reske, Martina</creatorcontrib><creatorcontrib>Halfter, Sarah</creatorcontrib><creatorcontrib>Sheldrick, Abigail J.</creatorcontrib><creatorcontrib>Radenbach, Katrin</creatorcontrib><creatorcontrib>Habel, Ute</creatorcontrib><creatorcontrib>Jon Shah, Nadim</creatorcontrib><creatorcontrib>Kircher, Tilo</creatorcontrib><title>Muscarinic antagonist effects on executive control of attention</title><title>The international journal of neuropsychopharmacology</title><addtitle>Int J Neuropsychopharmacol</addtitle><description>Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic resonance scanner. Neurocognitive measures included verbal learning, verbal memory, verbal fluency, trail making, digit span, a continuous performance task and a planning task (Tower of London). When compared to placebo, scopolamine increased reaction times for conflicting stimulus processing, together with decreasing brain activation in the anterior cingulate cortex (a brain region involved in conflict processing) suggestive of a muscarinic antagonist effect on executive control of attention. Contrary to the notion of a predominantly right-hemispheric lateralization of cognitive processes associated with orienting attention, scopolamine reduced brain activity in left superior and left middle frontal brain areas. Our neuropsychological test data revealed a selective effect of scopolamine on verbal learning and memory while other cognitive domains, such as planning and working memory, were unaffected. These findings are consistent with muscarinic modulation of dopaminergic neurotransmission in frontal attention networks when processing conflicting information.</description><subject>Adult</subject><subject>Attention - drug effects</subject><subject>Attention - physiology</subject><subject>Cross-Over Studies</subject><subject>Executive Function - drug effects</subject><subject>Executive Function - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychomotor Performance - physiology</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Scopolamine Hydrobromide - pharmacology</subject><subject>Single-Blind Method</subject><subject>Young Adult</subject><issn>1461-1457</issn><issn>1469-5111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctKBTEMhoso3h_AjQwudDWaTG_TlYh4A8WFCu6GTqeVkXNabTuib-8czwFB0VVC8uUP-UPIDsIhAsqjO2QCkXEJSikQ9eMSWR9LquSIuPyVYznrr5GNlJ4BKsapWCVrqKSiDKp1cnwzJKNj73tTaJ_1U_B9yoV1zpqciuAL-27NkPs3W5jgcwyTIrhC52x97oPfIitOT5LdXsRN8nB-dn96WV7fXlydnlyXhnOVSyc6lB3TzNCWOcc0CGM6qLqWYs0rURvhaukkcCFby2qtXOuoa4EbUBok3SQHc92XGF4Hm3Iz7ZOxk4n2NgypkZQyiQzESO7_S1ajY4JJPoJ7P8DnMEQ_XtFUVUUFANYjhHPIxJBStK55if1Ux48GoZk9ofn1hHFmdyE8tFPbfU8sXB8BuhDV0zb23ZP9Xv237CcaO5Df</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Thienel, Renate</creator><creator>Kellermann, Thilo</creator><creator>Schall, Ulrich</creator><creator>Voss, Bianca</creator><creator>Reske, Martina</creator><creator>Halfter, Sarah</creator><creator>Sheldrick, Abigail J.</creator><creator>Radenbach, Katrin</creator><creator>Habel, Ute</creator><creator>Jon Shah, Nadim</creator><creator>Kircher, Tilo</creator><general>Cambridge University Press</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Muscarinic antagonist effects on executive control of attention</title><author>Thienel, Renate ; Kellermann, Thilo ; Schall, Ulrich ; Voss, Bianca ; Reske, Martina ; Halfter, Sarah ; Sheldrick, Abigail J. ; Radenbach, Katrin ; Habel, Ute ; Jon Shah, Nadim ; Kircher, Tilo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-f6d17d4a4c3b4ff4a06ccd02db3185268c6f87f70567be48a9fbf3fb05c09a073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Attention - drug effects</topic><topic>Attention - physiology</topic><topic>Cross-Over Studies</topic><topic>Executive Function - drug effects</topic><topic>Executive Function - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychomotor Performance - physiology</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Scopolamine Hydrobromide - pharmacology</topic><topic>Single-Blind Method</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thienel, Renate</creatorcontrib><creatorcontrib>Kellermann, Thilo</creatorcontrib><creatorcontrib>Schall, Ulrich</creatorcontrib><creatorcontrib>Voss, Bianca</creatorcontrib><creatorcontrib>Reske, Martina</creatorcontrib><creatorcontrib>Halfter, Sarah</creatorcontrib><creatorcontrib>Sheldrick, Abigail J.</creatorcontrib><creatorcontrib>Radenbach, Katrin</creatorcontrib><creatorcontrib>Habel, Ute</creatorcontrib><creatorcontrib>Jon Shah, Nadim</creatorcontrib><creatorcontrib>Kircher, Tilo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thienel, Renate</au><au>Kellermann, Thilo</au><au>Schall, Ulrich</au><au>Voss, Bianca</au><au>Reske, Martina</au><au>Halfter, Sarah</au><au>Sheldrick, Abigail J.</au><au>Radenbach, Katrin</au><au>Habel, Ute</au><au>Jon Shah, Nadim</au><au>Kircher, Tilo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscarinic antagonist effects on executive control of attention</atitle><jtitle>The international journal of neuropsychopharmacology</jtitle><addtitle>Int J Neuropsychopharmacol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>12</volume><issue>10</issue><spage>1307</spage><epage>1317</epage><pages>1307-1317</pages><issn>1461-1457</issn><eissn>1469-5111</eissn><abstract>Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic resonance scanner. Neurocognitive measures included verbal learning, verbal memory, verbal fluency, trail making, digit span, a continuous performance task and a planning task (Tower of London). When compared to placebo, scopolamine increased reaction times for conflicting stimulus processing, together with decreasing brain activation in the anterior cingulate cortex (a brain region involved in conflict processing) suggestive of a muscarinic antagonist effect on executive control of attention. Contrary to the notion of a predominantly right-hemispheric lateralization of cognitive processes associated with orienting attention, scopolamine reduced brain activity in left superior and left middle frontal brain areas. Our neuropsychological test data revealed a selective effect of scopolamine on verbal learning and memory while other cognitive domains, such as planning and working memory, were unaffected. These findings are consistent with muscarinic modulation of dopaminergic neurotransmission in frontal attention networks when processing conflicting information.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>19793402</pmid><doi>10.1017/S146114570999068X</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Attention - drug effects Attention - physiology Cross-Over Studies Executive Function - drug effects Executive Function - physiology Humans Male Muscarinic Antagonists - pharmacology Psychomotor Performance - drug effects Psychomotor Performance - physiology Reaction Time - drug effects Reaction Time - physiology Scopolamine Hydrobromide - pharmacology Single-Blind Method Young Adult |
title | Muscarinic antagonist effects on executive control of attention |
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