Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins

We examined the regulation of glutamate transporter protein expression after stimulation with selective metabotropic glutamate receptor (mGluR) agonists in cultured human glial cells. mGluR3 and mGluR5 are expressed in human astrocytes and in human glioma cells in vivo as well as in vitro, as shown...

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Veröffentlicht in:	The European journal of neuroscience 2003-05, Vol.17 (10), p.2106-2118
Hauptverfasser:	Aronica, Eleonora, Gorter, Jan A., Ijlst-Keizers, Helen, Rozemuller, Annemieke J., Yankaya, Bulent, Leenstra, Sieger, Troost, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amino Acid Transport System X-AG - genetics Amino Acid Transport System X-AG - metabolism Astrocytes - cytology Astrocytes - physiology cultures Excitatory Amino Acid Transporter 1 Excitatory Amino Acid Transporter 2 - genetics Excitatory Amino Acid Transporter 2 - metabolism Excitatory Amino Acid Transporter 3 Gene Expression - drug effects Gene Expression - physiology Glioblastoma glioma Glutamate Plasma Membrane Transport Proteins glutamate transporters Growth Substances - pharmacology human astrocytes Humans Immunophenotyping metabotropic glutamate receptors Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Symporters - genetics Symporters - metabolism Tumor Cells, Cultured western blot
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