Chromosomal Instability Detected by Fluorescence in Situ Hybridization in Surgical Specimens of Non-Small Cell Lung Cancer Is Associated with Poor Survival
Purpose: Chromosomal instability (CIN) in non-small cell lungcancer (NSCLC) has yet to be well studied. We examined the relationship between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC. Experimental Design: Touch preparations from 50 surgical specimens of N...
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| Veröffentlicht in: | Clinical cancer research 2003-06, Vol.9 (6), p.2294-2299 |
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| container_title | Clinical cancer research |
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| creator | NAKAMURA, Haruhiko SAJI, Hisashi IDIRIS, Aute KAWASAKI, Norihito HOSAKA, Makoto OGATA, Akihiko SAIJO, Takamoto KATO, Harubimi |
| description | Purpose: Chromosomal instability (CIN) in non-small cell lungcancer (NSCLC) has yet to be well studied. We examined the relationship
between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC.
Experimental Design: Touch preparations from 50 surgical specimens of NSCLC were studied. Tumors included 34 adenocarcinomas, 15 squamous cell
carcinomas, and 1 large cell carcinoma. The pathologic stage was IA in 14, IB in 17, IIB in 8, IIIA in 9, and IIIB in 2 cases.
Enumeration of chromosomes 3, 10, 11, and 17 was used to determine which tumors carried CIN. The association between CIN and
survival was also analyzed.
Results: Disomy was most common, but tetrasomy and trisomy of the examined chromosomes were seen frequently. Fourteen tumors (28%)
showed heterogeneity of all four chromosomes examined and were judged to be carrying CIN. Both univariate and multivariate
analyses revealed that two factors, lymph node metastasis and CIN, were significant poor prognostic factors.
Conclusions: CIN in NSCLC detected by fluorescence in situ hybridization is an independent factor predicting a poor prognosis. |
| format | Article |
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between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC.
Experimental Design: Touch preparations from 50 surgical specimens of NSCLC were studied. Tumors included 34 adenocarcinomas, 15 squamous cell
carcinomas, and 1 large cell carcinoma. The pathologic stage was IA in 14, IB in 17, IIB in 8, IIIA in 9, and IIIB in 2 cases.
Enumeration of chromosomes 3, 10, 11, and 17 was used to determine which tumors carried CIN. The association between CIN and
survival was also analyzed.
Results: Disomy was most common, but tetrasomy and trisomy of the examined chromosomes were seen frequently. Fourteen tumors (28%)
showed heterogeneity of all four chromosomes examined and were judged to be carrying CIN. Both univariate and multivariate
analyses revealed that two factors, lymph node metastasis and CIN, were significant poor prognostic factors.
Conclusions: CIN in NSCLC detected by fluorescence in situ hybridization is an independent factor predicting a poor prognosis.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 12796398</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Chromosomal Instability ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Lung Neoplasms - genetics ; Male ; Medical sciences ; Pneumology ; Tumors of the respiratory system and mediastinum</subject><ispartof>Clinical cancer research, 2003-06, Vol.9 (6), p.2294-2299</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14882786$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12796398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKAMURA, Haruhiko</creatorcontrib><creatorcontrib>SAJI, Hisashi</creatorcontrib><creatorcontrib>IDIRIS, Aute</creatorcontrib><creatorcontrib>KAWASAKI, Norihito</creatorcontrib><creatorcontrib>HOSAKA, Makoto</creatorcontrib><creatorcontrib>OGATA, Akihiko</creatorcontrib><creatorcontrib>SAIJO, Takamoto</creatorcontrib><creatorcontrib>KATO, Harubimi</creatorcontrib><title>Chromosomal Instability Detected by Fluorescence in Situ Hybridization in Surgical Specimens of Non-Small Cell Lung Cancer Is Associated with Poor Survival</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Chromosomal instability (CIN) in non-small cell lungcancer (NSCLC) has yet to be well studied. We examined the relationship
between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC.
Experimental Design: Touch preparations from 50 surgical specimens of NSCLC were studied. Tumors included 34 adenocarcinomas, 15 squamous cell
carcinomas, and 1 large cell carcinoma. The pathologic stage was IA in 14, IB in 17, IIB in 8, IIIA in 9, and IIIB in 2 cases.
Enumeration of chromosomes 3, 10, 11, and 17 was used to determine which tumors carried CIN. The association between CIN and
survival was also analyzed.
Results: Disomy was most common, but tetrasomy and trisomy of the examined chromosomes were seen frequently. Fourteen tumors (28%)
showed heterogeneity of all four chromosomes examined and were judged to be carrying CIN. Both univariate and multivariate
analyses revealed that two factors, lymph node metastasis and CIN, were significant poor prognostic factors.
Conclusions: CIN in NSCLC detected by fluorescence in situ hybridization is an independent factor predicting a poor prognosis.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Chromosomal Instability</subject><subject>Female</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9q3DAQh01paP60r1B0aXsyyJIsWcfgNs3CkgQ2ORtZnl1Psa2tJG_YvEpeNspmQy4zw_DxDfP7lJ0VZalyzmT5Oc1UVTkVnJ1m5yH8o7QQBRVfstOCKS25rs6y57r3bnTBjWYgiylE0-KAcU9-QwQboSPtnlwNs_MQLEwWCE5khXEm1_vWY4dPJqKbDtvZb9AmzWoLFkeYAnFrcuOmfJXkA6khleU8bUhtksiTRSCXITiL5vXOI8ae3DnnX0U73Jnha3ayNkOAb8d-kT1c_bmvr_Pl7d9FfbnMeyZ1zLs1LcEoyVTHpVZUlcoKXhRCayOAdaZqVWd0SUEJ4CVAq5jteGkrUVVUKn6R_Xzzbr37P0OIzYjp2WEwE7g5NIpzISWjCfx-BOd2hK7ZehyN3zfvcSbgxxEwISWx9ulRDB9cOshUJRP3643rcdM_oofGHiJJIYPxtm90IxvGtOAvwrOOwQ</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>NAKAMURA, Haruhiko</creator><creator>SAJI, Hisashi</creator><creator>IDIRIS, Aute</creator><creator>KAWASAKI, Norihito</creator><creator>HOSAKA, Makoto</creator><creator>OGATA, Akihiko</creator><creator>SAIJO, Takamoto</creator><creator>KATO, Harubimi</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Chromosomal Instability Detected by Fluorescence in Situ Hybridization in Surgical Specimens of Non-Small Cell Lung Cancer Is Associated with Poor Survival</title><author>NAKAMURA, Haruhiko ; SAJI, Hisashi ; IDIRIS, Aute ; KAWASAKI, Norihito ; HOSAKA, Makoto ; OGATA, Akihiko ; SAIJO, Takamoto ; KATO, Harubimi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-df05ea7627d36970757c4311499a4e2da8b7da950e74e35eeb72cd35c84880673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Chromosomal Instability</topic><topic>Female</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAKAMURA, Haruhiko</creatorcontrib><creatorcontrib>SAJI, Hisashi</creatorcontrib><creatorcontrib>IDIRIS, Aute</creatorcontrib><creatorcontrib>KAWASAKI, Norihito</creatorcontrib><creatorcontrib>HOSAKA, Makoto</creatorcontrib><creatorcontrib>OGATA, Akihiko</creatorcontrib><creatorcontrib>SAIJO, Takamoto</creatorcontrib><creatorcontrib>KATO, Harubimi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKAMURA, Haruhiko</au><au>SAJI, Hisashi</au><au>IDIRIS, Aute</au><au>KAWASAKI, Norihito</au><au>HOSAKA, Makoto</au><au>OGATA, Akihiko</au><au>SAIJO, Takamoto</au><au>KATO, Harubimi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomal Instability Detected by Fluorescence in Situ Hybridization in Surgical Specimens of Non-Small Cell Lung Cancer Is Associated with Poor Survival</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>9</volume><issue>6</issue><spage>2294</spage><epage>2299</epage><pages>2294-2299</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Chromosomal instability (CIN) in non-small cell lungcancer (NSCLC) has yet to be well studied. We examined the relationship
between CIN detected by fluorescence in situ hybridization and survival in patients with NSCLC.
Experimental Design: Touch preparations from 50 surgical specimens of NSCLC were studied. Tumors included 34 adenocarcinomas, 15 squamous cell
carcinomas, and 1 large cell carcinoma. The pathologic stage was IA in 14, IB in 17, IIB in 8, IIIA in 9, and IIIB in 2 cases.
Enumeration of chromosomes 3, 10, 11, and 17 was used to determine which tumors carried CIN. The association between CIN and
survival was also analyzed.
Results: Disomy was most common, but tetrasomy and trisomy of the examined chromosomes were seen frequently. Fourteen tumors (28%)
showed heterogeneity of all four chromosomes examined and were judged to be carrying CIN. Both univariate and multivariate
analyses revealed that two factors, lymph node metastasis and CIN, were significant poor prognostic factors.
Conclusions: CIN in NSCLC detected by fluorescence in situ hybridization is an independent factor predicting a poor prognosis.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>12796398</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Chromosomal Instability Female Humans In Situ Hybridization, Fluorescence Lung Neoplasms - genetics Male Medical sciences Pneumology Tumors of the respiratory system and mediastinum |
| title | Chromosomal Instability Detected by Fluorescence in Situ Hybridization in Surgical Specimens of Non-Small Cell Lung Cancer Is Associated with Poor Survival |
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