Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus
Recent work has suggested that immediate early genes are involved in the phase-shifting response of the circadian pacemaker to light. In mammals, the endogenous pacemaker is located in the suprachiasmatic nucleus (SCN). We report here a systematic examination of the expression of the immediate early...
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| Veröffentlicht in: | Brain research. Molecular brain research. 1992, Vol.15 (3), p.281-290 |
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| creator | Sutin, Ellen L. Kilduff, Thomas S. |
| description | Recent work has suggested that immediate early genes are involved in the phase-shifting response of the circadian pacemaker to light. In mammals, the endogenous pacemaker is located in the suprachiasmatic nucleus (SCN). We report here a systematic examination of the expression of the immediate early genes
fos, NGFI-A, and NGFI-B in the rat SCN, in basal and light-stimulated conditions across the circadian cycle. The photic induction of all three genes examined was found to be gated by the circadian system with maximal induction observed during the mid to late subjective night. The photic-induced expression of NGFI-B in the SCN was considerably less than that of NGFI-A, despite previous observations suggesting greater induction of NGFI-B by membrane depolarization. The levels of immediate early gene expression induced by light do not directly correspond to the magnitude of previously reported light-induced phase-shifts of the activity rhythm. The results also suggest that
fos may undergo a circadian rhythm of expression in the rat SCN. |
| doi_str_mv | 10.1016/0169-328X(92)90119-V |
| format | Article |
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fos, NGFI-A, and NGFI-B in the rat SCN, in basal and light-stimulated conditions across the circadian cycle. The photic induction of all three genes examined was found to be gated by the circadian system with maximal induction observed during the mid to late subjective night. The photic-induced expression of NGFI-B in the SCN was considerably less than that of NGFI-A, despite previous observations suggesting greater induction of NGFI-B by membrane depolarization. The levels of immediate early gene expression induced by light do not directly correspond to the magnitude of previously reported light-induced phase-shifts of the activity rhythm. The results also suggest that
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fos, NGFI-A, and NGFI-B in the rat SCN, in basal and light-stimulated conditions across the circadian cycle. The photic induction of all three genes examined was found to be gated by the circadian system with maximal induction observed during the mid to late subjective night. The photic-induced expression of NGFI-B in the SCN was considerably less than that of NGFI-A, despite previous observations suggesting greater induction of NGFI-B by membrane depolarization. The levels of immediate early gene expression induced by light do not directly correspond to the magnitude of previously reported light-induced phase-shifts of the activity rhythm. The results also suggest that
fos may undergo a circadian rhythm of expression in the rat SCN.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Biological Clock</subject><subject>Central nervous system</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - genetics</subject><subject>DNA Probes</subject><subject>fos</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Gene Expression Regulation - radiation effects</subject><subject>Genes, fos - genetics</subject><subject>In Situ Hybridization</subject><subject>Light</subject><subject>Male</subject><subject>NGFI-A</subject><subject>NGFI-B</subject><subject>Photic Stimulation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - physiology</subject><subject>Suprachiasmatic Nucleus - radiation effects</subject><subject>Transcription, Genetic - genetics</subject><subject>Transcription, Genetic - radiation effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo6-zqP1DIQUQPrfnqfFyEZXBVWBREF28hna6eiXSnx1S3uP_ebmdYb3ooQlFPFeF5CXnC2SvOuH69lKuksN9eOPHSMc5ddXOPbLg1otJO8ftkc4c8JOeI3xlj3HJ-Rs64lFxbsSG7bSoxtClkGnJL-7TbT1XK7RyhpfDrUAAxjZmOHU3DAAs4AYVQ-lu6gwx0-PzxEmnKdNoDLWGiOB9KiPsUcAhTijTPsYcZH5EHXegRHp_eC_L16u2X7fvq-tO7D9vL6yoqYaZK8boDx5kOUloLrtFW8kYzE8EI0TlnAJiqu9jqaBobTBS1MGtjnIMmyAvy_Hj3UMYfM-Dkh4QR-j5kGGf0RkqlhTT_BblWQki1guoIxjIiFuj8oaQhlFvPmV-D8Ktlv1r2Tvg_QfibZe3p6f7cLN7-Lh3NL_Nnp3nAGPquhBwT3mF1LWtl5YK9OWKwSPuZoHiMCfKSTioQJ9-O6d__-A1fCqVK</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Sutin, Ellen L.</creator><creator>Kilduff, Thomas S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus</title><author>Sutin, Ellen L. ; Kilduff, Thomas S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-415fe9106a3388e9b6831b607ce722f997ee045fcd6c7b8a7c2527d6c7799eba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Biological Clock</topic><topic>Central nervous system</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - genetics</topic><topic>DNA Probes</topic><topic>fos</topic><topic>Fundamental and applied biological sciences. 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Molecular brain research.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sutin, Ellen L.</au><au>Kilduff, Thomas S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus</atitle><jtitle>Brain research. Molecular brain research.</jtitle><addtitle>Brain Res Mol Brain Res</addtitle><date>1992</date><risdate>1992</risdate><volume>15</volume><issue>3</issue><spage>281</spage><epage>290</epage><pages>281-290</pages><issn>0169-328X</issn><eissn>1872-6941</eissn><abstract>Recent work has suggested that immediate early genes are involved in the phase-shifting response of the circadian pacemaker to light. In mammals, the endogenous pacemaker is located in the suprachiasmatic nucleus (SCN). We report here a systematic examination of the expression of the immediate early genes
fos, NGFI-A, and NGFI-B in the rat SCN, in basal and light-stimulated conditions across the circadian cycle. The photic induction of all three genes examined was found to be gated by the circadian system with maximal induction observed during the mid to late subjective night. The photic-induced expression of NGFI-B in the SCN was considerably less than that of NGFI-A, despite previous observations suggesting greater induction of NGFI-B by membrane depolarization. The levels of immediate early gene expression induced by light do not directly correspond to the magnitude of previously reported light-induced phase-shifts of the activity rhythm. The results also suggest that
fos may undergo a circadian rhythm of expression in the rat SCN.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1331682</pmid><doi>10.1016/0169-328X(92)90119-V</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research. Molecular brain research., 1992, Vol.15 (3), p.281-290 |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Biological Clock Central nervous system Circadian rhythm Circadian Rhythm - genetics DNA Probes fos Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Gene Expression Regulation - radiation effects Genes, fos - genetics In Situ Hybridization Light Male NGFI-A NGFI-B Photic Stimulation Rats Rats, Wistar RNA, Messenger - biosynthesis Suprachiasmatic nucleus Suprachiasmatic Nucleus - physiology Suprachiasmatic Nucleus - radiation effects Transcription, Genetic - genetics Transcription, Genetic - radiation effects Vertebrates: nervous system and sense organs |
| title | Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus |
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