A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia
Natural killer (NK)-cell leukemia/lymphoma is a rare entity that has been defined only in recent years. In the Revised European-American Lymphoma and World Health Organization classifications, only the mature NK-cell malignancies are included. However, at least 3 types of precursor NK-cell neoplasms...
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| Veröffentlicht in: | Human pathology 2003-05, Vol.34 (5), p.504-508 |
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| creator | Sun, Tsieh Pashaei, Shayesteh Jaffrey, Ira Ryder, John |
| description | Natural killer (NK)-cell leukemia/lymphoma is a rare entity that has been defined only in recent years. In the Revised European-American Lymphoma and World Health Organization classifications, only the mature NK-cell malignancies are included. However, at least 3 types of precursor NK-cell neoplasms have been reported in the literature. These include myeloid/NK-cell acute leukemia, myeloid/NK-cell precursor acute leukemia, and blastic NK-cell lymphoma/leukemia. These leukemias are characterized by the presence of blasts, which express CD56, in the peripheral blood, bone marrow, lymph nodes, and/or extranodal tissues. We report a case that is morphologically consistent with myeloid/NK-cell acute leukemia but immunologically is myeloid/NK-cell precursor acute leukemia. This case is unique in its cutaneous presentation without involvement of the peripheral blood. Extensive flow cytometric studies were performed on the skin biopsy and bone marrow aspirate specimens, which included many markers that had not been tested before in these entities. The clinical implications of these findings are discussed. |
| doi_str_mv | 10.1016/S0046-8177(03)00087-X |
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In the Revised European-American Lymphoma and World Health Organization classifications, only the mature NK-cell malignancies are included. However, at least 3 types of precursor NK-cell neoplasms have been reported in the literature. These include myeloid/NK-cell acute leukemia, myeloid/NK-cell precursor acute leukemia, and blastic NK-cell lymphoma/leukemia. These leukemias are characterized by the presence of blasts, which express CD56, in the peripheral blood, bone marrow, lymph nodes, and/or extranodal tissues. We report a case that is morphologically consistent with myeloid/NK-cell acute leukemia but immunologically is myeloid/NK-cell precursor acute leukemia. This case is unique in its cutaneous presentation without involvement of the peripheral blood. Extensive flow cytometric studies were performed on the skin biopsy and bone marrow aspirate specimens, which included many markers that had not been tested before in these entities. The clinical implications of these findings are discussed.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(03)00087-X</identifier><identifier>PMID: 12792926</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>acute biphenotypic leukemia ; Acute Disease ; Adult ; Antineoplastic Combined Chemotherapy Protocols ; Biological and medical sciences ; Bone Marrow - pathology ; Carmustine ; CD2 Antigens - metabolism ; Cytarabine ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; Immunophenotyping ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Leukemia, Lymphoid - immunology ; Leukemia, Lymphoid - metabolism ; Leukemia, Lymphoid - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Melphalan ; myeloid/NK-cell acute leukemia ; myeloid/NK-cell precursor acute leukemia ; Podophyllotoxin</subject><ispartof>Human pathology, 2003-05, Vol.34 (5), p.504-508</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-aa5e4b6c6974c6357b3e5fe8dff7627cccdbb92c3db9a4b442afb8b850a7733f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(03)00087-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14849578$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12792926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Tsieh</creatorcontrib><creatorcontrib>Pashaei, Shayesteh</creatorcontrib><creatorcontrib>Jaffrey, Ira</creatorcontrib><creatorcontrib>Ryder, John</creatorcontrib><title>A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Natural killer (NK)-cell leukemia/lymphoma is a rare entity that has been defined only in recent years. In the Revised European-American Lymphoma and World Health Organization classifications, only the mature NK-cell malignancies are included. However, at least 3 types of precursor NK-cell neoplasms have been reported in the literature. These include myeloid/NK-cell acute leukemia, myeloid/NK-cell precursor acute leukemia, and blastic NK-cell lymphoma/leukemia. These leukemias are characterized by the presence of blasts, which express CD56, in the peripheral blood, bone marrow, lymph nodes, and/or extranodal tissues. We report a case that is morphologically consistent with myeloid/NK-cell acute leukemia but immunologically is myeloid/NK-cell precursor acute leukemia. This case is unique in its cutaneous presentation without involvement of the peripheral blood. Extensive flow cytometric studies were performed on the skin biopsy and bone marrow aspirate specimens, which included many markers that had not been tested before in these entities. The clinical implications of these findings are discussed.</description><subject>acute biphenotypic leukemia</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Carmustine</subject><subject>CD2 Antigens - metabolism</subject><subject>Cytarabine</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Leukemia, Lymphoid - immunology</subject><subject>Leukemia, Lymphoid - metabolism</subject><subject>Leukemia, Lymphoid - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melphalan</subject><subject>myeloid/NK-cell acute leukemia</subject><subject>myeloid/NK-cell precursor acute leukemia</subject><subject>Podophyllotoxin</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1rFDEYx_FQlHat_RMqA6LoYWwyeZ2TlNKqWPSghR4KIS9PMO3MZE12hP3vzXYXC-3BUy6fPPz4InRM8AeCiTj5gTETrSJSvsP0PcZYyfZ6Dy0Ip12raN89Q4t_5AC9KOUWY0I44_vogHSy7_pOLNDNafNrbXP0TUh5bFJoxjUMKfqTb19bB8PQGDevoBlgvoMxmsZM_glZZnBzLik_wi_R82CGAke79xBdXZz_PPvcXn7_9OXs9LJ1TPFVawwHZoUTvWROUC4tBR5A-RCk6KRzzlvbd4562xtmGetMsMoqjo2UlAZ6iN5u7y5z-j1DWekxls0yM0Gai66ICSJoha8fwds056lu0wRTphgnglXFt8rlVEqGoJc5jiavK9Kb-Po-vt6U1Zjq-_j6uv57tbs-2xH8w69d7Qre7IApzgwhm8nF8uDqgJ5LVd3HrYMa7U-ErIuLMDnwsZZeaZ_if6b8BdvBoQ8</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Sun, Tsieh</creator><creator>Pashaei, Shayesteh</creator><creator>Jaffrey, Ira</creator><creator>Ryder, John</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia</title><author>Sun, Tsieh ; Pashaei, Shayesteh ; Jaffrey, Ira ; Ryder, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-aa5e4b6c6974c6357b3e5fe8dff7627cccdbb92c3db9a4b442afb8b850a7733f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>acute biphenotypic leukemia</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Carmustine</topic><topic>CD2 Antigens - metabolism</topic><topic>Cytarabine</topic><topic>Flow Cytometry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Leukemia, Lymphoid - immunology</topic><topic>Leukemia, Lymphoid - metabolism</topic><topic>Leukemia, Lymphoid - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melphalan</topic><topic>myeloid/NK-cell acute leukemia</topic><topic>myeloid/NK-cell precursor acute leukemia</topic><topic>Podophyllotoxin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Tsieh</creatorcontrib><creatorcontrib>Pashaei, Shayesteh</creatorcontrib><creatorcontrib>Jaffrey, Ira</creatorcontrib><creatorcontrib>Ryder, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Tsieh</au><au>Pashaei, Shayesteh</au><au>Jaffrey, Ira</au><au>Ryder, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>34</volume><issue>5</issue><spage>504</spage><epage>508</epage><pages>504-508</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Natural killer (NK)-cell leukemia/lymphoma is a rare entity that has been defined only in recent years. In the Revised European-American Lymphoma and World Health Organization classifications, only the mature NK-cell malignancies are included. However, at least 3 types of precursor NK-cell neoplasms have been reported in the literature. These include myeloid/NK-cell acute leukemia, myeloid/NK-cell precursor acute leukemia, and blastic NK-cell lymphoma/leukemia. These leukemias are characterized by the presence of blasts, which express CD56, in the peripheral blood, bone marrow, lymph nodes, and/or extranodal tissues. We report a case that is morphologically consistent with myeloid/NK-cell acute leukemia but immunologically is myeloid/NK-cell precursor acute leukemia. This case is unique in its cutaneous presentation without involvement of the peripheral blood. Extensive flow cytometric studies were performed on the skin biopsy and bone marrow aspirate specimens, which included many markers that had not been tested before in these entities. The clinical implications of these findings are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12792926</pmid><doi>10.1016/S0046-8177(03)00087-X</doi><tpages>5</tpages></addata></record> |
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| subjects | acute biphenotypic leukemia Acute Disease Adult Antineoplastic Combined Chemotherapy Protocols Biological and medical sciences Bone Marrow - pathology Carmustine CD2 Antigens - metabolism Cytarabine Flow Cytometry Hematologic and hematopoietic diseases Humans Immunophenotyping Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Leukemia, Lymphoid - immunology Leukemia, Lymphoid - metabolism Leukemia, Lymphoid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Melphalan myeloid/NK-cell acute leukemia myeloid/NK-cell precursor acute leukemia Podophyllotoxin |
| title | A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia |
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