Lewis Acid-Induced Intramolecular Friedel−Crafts Cyclization of 1,3-Bis-exocyclic Dienes. A New Route to 4a-Methyltetrahydrofluorenes

Lewis Acid-Induced Intramolecular Friedel−Crafts Cyclization of 1,3-Bis-exocyclic Dienes. A New Route to 4a-Methyltetrahydrofluorenes

An efficient new method for constructing the 4a-methyltetrahydrofluorene skeleton was achieved via Friedel−Crafts intramolecular cyclization of 1,3-bis-exocyclic dienes. This strategy offers a simple and promising method for accessing complex structures.

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Veröffentlicht in:Organic letters 2003-06, Vol.5 (12), p.2055-2057
Hauptverfasser: Lomberget, Thierry, Bentz, Emilie, Bouyssi, Didier, Balme, Geneviève
Format: Artikel
Sprache:eng
Schlagworte:
Alkadienes - chemistry
Boron Compounds - chemistry
Catalysis
Chemistry, Organic - methods
Cyclization
Fluorenes - chemical synthesis
Fluorenes - chemistry
Molecular Conformation
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Zusammenfassung:An efficient new method for constructing the 4a-methyltetrahydrofluorene skeleton was achieved via Friedel−Crafts intramolecular cyclization of 1,3-bis-exocyclic dienes. This strategy offers a simple and promising method for accessing complex structures.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0344265