Interplay between human leukocyte antigen genes and the microbial colonization process of the newborn intestine
Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified acc...
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| creator | De Palma, G Capilla, A Nadal, I Nova, E Pozo, T Varea, V Polanco, I Castillejo, G López, A Garrote, J A Calvo, C García-Novo, M D Cilleruelo, M L Ribes-Koninckx, C Palau, F Sanz, Y |
| description | Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and low genetic risk groups, showing 24-28%, 7-8% and less than 1% probability to develop CD, respectively. Faecal microbiota was analysed at 7 days, 1 and 4 months of children's age by fluorescence in situ hybridization. When considering all data, Gram-negative bacteria and Bacteroides-Prevotella group proportions were higher (P |
| doi_str_mv | 10.21775/cimb.012.001 |
| format | Article |
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Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and low genetic risk groups, showing 24-28%, 7-8% and less than 1% probability to develop CD, respectively. Faecal microbiota was analysed at 7 days, 1 and 4 months of children's age by fluorescence in situ hybridization. When considering all data, Gram-negative bacteria and Bacteroides-Prevotella group proportions were higher (P<0.05) in the high than in the intermediate and low genetic risk groups. E. coli, Streptococcus-Lactococcus, E. rectale-C. coccoides, sulphate-reducing bacteria, C. lituseburense and C. histolyticum group proportions were also significantly higher (P<0.05) in the high than in the low genetic risk group. Correlations between these bacterial groups and the genetic risk were also detected (P<0.05). In addition, the number and type of CD relative seemed to influence (P<0.050) these bacterial proportions in children at CD risk. At 4 months of age, similar relationships were established between the high genetic risk to develop CD and the proportions of Streptococcus-Lactococcus (P<0.05), E. rectale-C. coccoides (P<0.05), C. lituseburense (P<0.05), C. histolyticum (P<0.05), Bacteroides-Prevotella (P<0.10) groups and total Gram-negative bacteria (P<0.05). The results suggest a relationship between HLA-DQ genes and the gut microbial colonization process that could lead to a change in the way this disorder is investigated.]]></description><identifier>ISSN: 1467-3037</identifier><identifier>EISSN: 1467-3045</identifier><identifier>DOI: 10.21775/cimb.012.001</identifier><identifier>PMID: 19478349</identifier><language>eng</language><publisher>Switzerland</publisher><subject><![CDATA[Bacteroides - growth & development ; Bacteroides - isolation & purification ; Flow Cytometry ; Genotype ; HLA-DQ alpha-Chains ; HLA-DQ Antigens - genetics ; HLA-DQ beta-Chains ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Infant, Newborn ; Intestines - microbiology ; Lactococcus - growth & development ; Lactococcus - isolation & purification ; Prevotella - growth & development ; Prevotella - isolation & purification ; Streptococcus - growth & development ; Streptococcus - isolation & purification]]></subject><ispartof>Current Issues in Molecular Biology, 2010, Vol.12 (1), p.1-10</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-5e7fef70c25e8459f8f20415234972dfbdf2bce21603649c73fcb78fba46b2b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19478349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Palma, G</creatorcontrib><creatorcontrib>Capilla, A</creatorcontrib><creatorcontrib>Nadal, I</creatorcontrib><creatorcontrib>Nova, E</creatorcontrib><creatorcontrib>Pozo, T</creatorcontrib><creatorcontrib>Varea, V</creatorcontrib><creatorcontrib>Polanco, I</creatorcontrib><creatorcontrib>Castillejo, G</creatorcontrib><creatorcontrib>López, A</creatorcontrib><creatorcontrib>Garrote, J A</creatorcontrib><creatorcontrib>Calvo, C</creatorcontrib><creatorcontrib>García-Novo, M D</creatorcontrib><creatorcontrib>Cilleruelo, M L</creatorcontrib><creatorcontrib>Ribes-Koninckx, C</creatorcontrib><creatorcontrib>Palau, F</creatorcontrib><creatorcontrib>Sanz, Y</creatorcontrib><title>Interplay between human leukocyte antigen genes and the microbial colonization process of the newborn intestine</title><title>Current Issues in Molecular Biology</title><addtitle>Curr Issues Mol Biol</addtitle><description><![CDATA[Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and low genetic risk groups, showing 24-28%, 7-8% and less than 1% probability to develop CD, respectively. Faecal microbiota was analysed at 7 days, 1 and 4 months of children's age by fluorescence in situ hybridization. When considering all data, Gram-negative bacteria and Bacteroides-Prevotella group proportions were higher (P<0.05) in the high than in the intermediate and low genetic risk groups. E. coli, Streptococcus-Lactococcus, E. rectale-C. coccoides, sulphate-reducing bacteria, C. lituseburense and C. histolyticum group proportions were also significantly higher (P<0.05) in the high than in the low genetic risk group. Correlations between these bacterial groups and the genetic risk were also detected (P<0.05). In addition, the number and type of CD relative seemed to influence (P<0.050) these bacterial proportions in children at CD risk. At 4 months of age, similar relationships were established between the high genetic risk to develop CD and the proportions of Streptococcus-Lactococcus (P<0.05), E. rectale-C. coccoides (P<0.05), C. lituseburense (P<0.05), C. histolyticum (P<0.05), Bacteroides-Prevotella (P<0.10) groups and total Gram-negative bacteria (P<0.05). The results suggest a relationship between HLA-DQ genes and the gut microbial colonization process that could lead to a change in the way this disorder is investigated.]]></description><subject>Bacteroides - growth & development</subject><subject>Bacteroides - isolation & purification</subject><subject>Flow Cytometry</subject><subject>Genotype</subject><subject>HLA-DQ alpha-Chains</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ beta-Chains</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intestines - microbiology</subject><subject>Lactococcus - growth & development</subject><subject>Lactococcus - isolation & purification</subject><subject>Prevotella - growth & development</subject><subject>Prevotella - isolation & purification</subject><subject>Streptococcus - growth & development</subject><subject>Streptococcus - isolation & purification</subject><issn>1467-3037</issn><issn>1467-3045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EoqUwsiJvTCn-SpyMqOKjUiUWmCPbOVNDYpc4UVV-PaatYLDssx69d_cgdE3JnFEp8zvjOj0nlM0JoSdoSkUhM05Efvr35nKCLmL8ICSXpaTnaEIrIUsuqikKSz9Av2nVDmsYtgAer8dOedzC-BnMbgCs_ODe0386EFPV4GENuHOmD9qpFpvQBu--1eCCx5s-GIgRB7unPGx16D12qUscnIdLdGZVG-HqeM_Q2-PD6-I5W708LRf3q8xwTocsB2nBSmJYDqXIK1taRgTNWRpassbqxjJtgNGC8EJURnJrtCytVqLQTFM-Q7eH3DTQ15h6152LBtpWeQhjrCXnKVaURSKzA5n2ibEHW29616l-V1NS7xXXv4rrpLhOihN_c0wedQfNP310yn8AWGt6Mw</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>De Palma, G</creator><creator>Capilla, A</creator><creator>Nadal, I</creator><creator>Nova, E</creator><creator>Pozo, T</creator><creator>Varea, V</creator><creator>Polanco, I</creator><creator>Castillejo, G</creator><creator>López, A</creator><creator>Garrote, J A</creator><creator>Calvo, C</creator><creator>García-Novo, M D</creator><creator>Cilleruelo, M L</creator><creator>Ribes-Koninckx, C</creator><creator>Palau, F</creator><creator>Sanz, Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Interplay between human leukocyte antigen genes and the microbial colonization process of the newborn intestine</title><author>De Palma, G ; Capilla, A ; Nadal, I ; Nova, E ; Pozo, T ; Varea, V ; Polanco, I ; Castillejo, G ; López, A ; Garrote, J A ; Calvo, C ; García-Novo, M D ; Cilleruelo, M L ; Ribes-Koninckx, C ; Palau, F ; Sanz, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-5e7fef70c25e8459f8f20415234972dfbdf2bce21603649c73fcb78fba46b2b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Bacteroides - growth & development</topic><topic>Bacteroides - isolation & purification</topic><topic>Flow Cytometry</topic><topic>Genotype</topic><topic>HLA-DQ alpha-Chains</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ beta-Chains</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intestines - microbiology</topic><topic>Lactococcus - growth & development</topic><topic>Lactococcus - isolation & purification</topic><topic>Prevotella - growth & development</topic><topic>Prevotella - isolation & purification</topic><topic>Streptococcus - growth & development</topic><topic>Streptococcus - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Palma, G</creatorcontrib><creatorcontrib>Capilla, A</creatorcontrib><creatorcontrib>Nadal, I</creatorcontrib><creatorcontrib>Nova, E</creatorcontrib><creatorcontrib>Pozo, T</creatorcontrib><creatorcontrib>Varea, V</creatorcontrib><creatorcontrib>Polanco, I</creatorcontrib><creatorcontrib>Castillejo, G</creatorcontrib><creatorcontrib>López, A</creatorcontrib><creatorcontrib>Garrote, J A</creatorcontrib><creatorcontrib>Calvo, C</creatorcontrib><creatorcontrib>García-Novo, M D</creatorcontrib><creatorcontrib>Cilleruelo, M L</creatorcontrib><creatorcontrib>Ribes-Koninckx, C</creatorcontrib><creatorcontrib>Palau, F</creatorcontrib><creatorcontrib>Sanz, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current Issues in Molecular Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Palma, G</au><au>Capilla, A</au><au>Nadal, I</au><au>Nova, E</au><au>Pozo, T</au><au>Varea, V</au><au>Polanco, I</au><au>Castillejo, G</au><au>López, A</au><au>Garrote, J A</au><au>Calvo, C</au><au>García-Novo, M D</au><au>Cilleruelo, M L</au><au>Ribes-Koninckx, C</au><au>Palau, F</au><au>Sanz, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interplay between human leukocyte antigen genes and the microbial colonization process of the newborn intestine</atitle><jtitle>Current Issues in Molecular Biology</jtitle><addtitle>Curr Issues Mol Biol</addtitle><date>2010</date><risdate>2010</risdate><volume>12</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1467-3037</issn><eissn>1467-3045</eissn><abstract><![CDATA[Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and low genetic risk groups, showing 24-28%, 7-8% and less than 1% probability to develop CD, respectively. Faecal microbiota was analysed at 7 days, 1 and 4 months of children's age by fluorescence in situ hybridization. When considering all data, Gram-negative bacteria and Bacteroides-Prevotella group proportions were higher (P<0.05) in the high than in the intermediate and low genetic risk groups. E. coli, Streptococcus-Lactococcus, E. rectale-C. coccoides, sulphate-reducing bacteria, C. lituseburense and C. histolyticum group proportions were also significantly higher (P<0.05) in the high than in the low genetic risk group. Correlations between these bacterial groups and the genetic risk were also detected (P<0.05). In addition, the number and type of CD relative seemed to influence (P<0.050) these bacterial proportions in children at CD risk. At 4 months of age, similar relationships were established between the high genetic risk to develop CD and the proportions of Streptococcus-Lactococcus (P<0.05), E. rectale-C. coccoides (P<0.05), C. lituseburense (P<0.05), C. histolyticum (P<0.05), Bacteroides-Prevotella (P<0.10) groups and total Gram-negative bacteria (P<0.05). The results suggest a relationship between HLA-DQ genes and the gut microbial colonization process that could lead to a change in the way this disorder is investigated.]]></abstract><cop>Switzerland</cop><pmid>19478349</pmid><doi>10.21775/cimb.012.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bacteroides - growth & development Bacteroides - isolation & purification Flow Cytometry Genotype HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DQ beta-Chains Humans In Situ Hybridization, Fluorescence Infant Infant, Newborn Intestines - microbiology Lactococcus - growth & development Lactococcus - isolation & purification Prevotella - growth & development Prevotella - isolation & purification Streptococcus - growth & development Streptococcus - isolation & purification |
| title | Interplay between human leukocyte antigen genes and the microbial colonization process of the newborn intestine |
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