ZAP-70 POSITIVE CELLS IN TREATED AND UNTREATED HIV-1 INFECTED PATIENTS

ZAP-70 is a critical protein tyrosine kinase in T-cell activation and proliferation processes. Defective recruitment of ZAP-70 molecules results in termination of the T-cell receptor (TCR) signal transduction pathway. Impairment of this pathway is one of the early markers of disease progression in H...

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