Insulin-Like Growth Factor-I Enhances Transforming Growth Factor-β-Induced Extracellular Matrix Protein Production Through the P38/Activating Transcription Factor-2 Signaling Pathway in Keloid Fibroblasts

Keloids are benign dermal tumors, characterized by invasive growth of fibroblasts and concomitant increased biosynthesis of extracellular matrix components, with unclear etiology. We previously demonstrated that keloid fibroblasts overexpress insulin-like growth factor-I receptor. In investigating t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of investigative dermatology 2003-06, Vol.120 (6), p.956-962
Hauptverfasser:	Daian, Takehiro, Ishihara, Hiroshi, Hirano, Akiyoshi, Fujii, Tohru, Ohtsuru, Akira, Rogounovitch, Tatiana, Akiyama-Uchida, Yuri, Saenko, Vladimir, Yamashita, Shunichi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Activating Transcription Factor 2 Adolescent Adult Aged Animals Biological and medical sciences Cells, Cultured Child collagen type I Collagen Type I - genetics Cyclic AMP Response Element-Binding Protein - metabolism Dermatology Dermis - metabolism Extracellular Matrix Proteins - metabolism Female Fibroblasts - metabolism fibronectin fibrosis Humans Insulin-Like Growth Factor I - metabolism Keloid - metabolism Male Medical sciences Mice Mice, Inbred BALB C Middle Aged mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases plasminogen activator inhibitor-1 RNA, Messenger - metabolism Signal Transduction Skin involvement in other diseases. Miscellaneous. General aspects Transcription Factors - metabolism Transforming Growth Factor beta - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!