relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes
Aims/hypothesis We examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy. Methods Persons with type 1 diabetes mellitus had gradable fundus photographs and renal biopsy...
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| Veröffentlicht in: | Diabetologia 2010-08, Vol.53 (8), p.1638-1646 |
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| creator | Klein, R Knudtson, M. D Klein, B. E. K Zinman, B Gardiner, R Suissa, S Sinaiko, A. R Donnelly, S. M Goodyer, P Strand, T Mauer, M |
| description | Aims/hypothesis We examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy. Methods Persons with type 1 diabetes mellitus had gradable fundus photographs and renal biopsy data at baseline and 5-year follow-up (n = 234). Retinal arteriolar and venular diameters were measured at baseline and follow-up. Central retinal arteriole equivalent (CRAE) and central retinal venule equivalent (CRVE) were computed. Baseline and 5-year follow-up renal structural variables were assessed by masked electron microscopic morphometric analyses from percutaneous renal biopsy specimens. Variables assessed included: mesangial fractional volume, glomerular basement membrane width, mesangial matrix fractional volume and glomerular basement membrane width composite glomerulopathy index. Results While controlling for other covariates, baseline CRAE was positively associated with change in the glomerulopathy index over the 5-year period. Change in CRAE was inversely related to a change in mesangial matrix fractional volume and abnormal mesangial matrix fractional volume, while change in CRVE was directly related to change in the volume fraction of cortex that was interstitium [Vv ₍Int/cortex₎] over the 5-year period. Baseline CRAE or CRVE or changes in these diameters were not related to changes in other anatomical or functional renal endpoints. Conclusions/interpretation Independently of other factors, baseline CRAE correlated with changes in glomerulopathy index, a composite measure of extracellular matrix accumulation in the mesangium and glomerular basement membrane. A narrowing of the CRAE was related to mesangial matrix accumulation. Changes in CRVE were related to changes in Vv ₍Int/cortex₎, a measure of interstitial expansion in persons with type 1 diabetes mellitus. |
| doi_str_mv | 10.1007/s00125-010-1763-3 |
| format | Article |
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D ; Klein, B. E. K ; Zinman, B ; Gardiner, R ; Suissa, S ; Sinaiko, A. R ; Donnelly, S. M ; Goodyer, P ; Strand, T ; Mauer, M</creator><creatorcontrib>Klein, R ; Knudtson, M. D ; Klein, B. E. K ; Zinman, B ; Gardiner, R ; Suissa, S ; Sinaiko, A. R ; Donnelly, S. M ; Goodyer, P ; Strand, T ; Mauer, M</creatorcontrib><description>Aims/hypothesis We examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy. Methods Persons with type 1 diabetes mellitus had gradable fundus photographs and renal biopsy data at baseline and 5-year follow-up (n = 234). Retinal arteriolar and venular diameters were measured at baseline and follow-up. Central retinal arteriole equivalent (CRAE) and central retinal venule equivalent (CRVE) were computed. Baseline and 5-year follow-up renal structural variables were assessed by masked electron microscopic morphometric analyses from percutaneous renal biopsy specimens. Variables assessed included: mesangial fractional volume, glomerular basement membrane width, mesangial matrix fractional volume and glomerular basement membrane width composite glomerulopathy index. Results While controlling for other covariates, baseline CRAE was positively associated with change in the glomerulopathy index over the 5-year period. Change in CRAE was inversely related to a change in mesangial matrix fractional volume and abnormal mesangial matrix fractional volume, while change in CRVE was directly related to change in the volume fraction of cortex that was interstitium [Vv ₍Int/cortex₎] over the 5-year period. Baseline CRAE or CRVE or changes in these diameters were not related to changes in other anatomical or functional renal endpoints. Conclusions/interpretation Independently of other factors, baseline CRAE correlated with changes in glomerulopathy index, a composite measure of extracellular matrix accumulation in the mesangium and glomerular basement membrane. A narrowing of the CRAE was related to mesangial matrix accumulation. Changes in CRVE were related to changes in Vv ₍Int/cortex₎, a measure of interstitial expansion in persons with type 1 diabetes mellitus.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-010-1763-3</identifier><identifier>PMID: 20437026</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adolescent ; Adult ; Analysis of Variance ; Associated diseases and complications ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - pathology ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - physiopathology ; Double-Blind Method ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fundamental and applied biological sciences. Psychology ; Human Physiology ; Humans ; Internal Medicine ; Kidney - pathology ; Kidney - physiopathology ; kidney diseases ; Kidneys ; Logistic Models ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Microvascular disease ; Middle Aged ; Nephrology. Urinary tract diseases ; Retinal blood vessel diameters ; Retinal Vessels - pathology ; Retinal Vessels - physiopathology ; Risk indicators ; Type 1 diabetes mellitus ; Urinary system involvement in other diseases. Miscellaneous ; Vertebrates: nervous system and sense organs</subject><ispartof>Diabetologia, 2010-08, Vol.53 (8), p.1638-1646</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-34e3260a3db9595056952669f66f8815f742f1d9416f8631fdeb31ced5c76d33</citedby><cites>FETCH-LOGICAL-c467t-34e3260a3db9595056952669f66f8815f742f1d9416f8631fdeb31ced5c76d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-010-1763-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-010-1763-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22975915$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20437026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, R</creatorcontrib><creatorcontrib>Knudtson, M. D</creatorcontrib><creatorcontrib>Klein, B. E. K</creatorcontrib><creatorcontrib>Zinman, B</creatorcontrib><creatorcontrib>Gardiner, R</creatorcontrib><creatorcontrib>Suissa, S</creatorcontrib><creatorcontrib>Sinaiko, A. R</creatorcontrib><creatorcontrib>Donnelly, S. M</creatorcontrib><creatorcontrib>Goodyer, P</creatorcontrib><creatorcontrib>Strand, T</creatorcontrib><creatorcontrib>Mauer, M</creatorcontrib><title>relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims/hypothesis We examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy. Methods Persons with type 1 diabetes mellitus had gradable fundus photographs and renal biopsy data at baseline and 5-year follow-up (n = 234). Retinal arteriolar and venular diameters were measured at baseline and follow-up. Central retinal arteriole equivalent (CRAE) and central retinal venule equivalent (CRVE) were computed. Baseline and 5-year follow-up renal structural variables were assessed by masked electron microscopic morphometric analyses from percutaneous renal biopsy specimens. Variables assessed included: mesangial fractional volume, glomerular basement membrane width, mesangial matrix fractional volume and glomerular basement membrane width composite glomerulopathy index. Results While controlling for other covariates, baseline CRAE was positively associated with change in the glomerulopathy index over the 5-year period. Change in CRAE was inversely related to a change in mesangial matrix fractional volume and abnormal mesangial matrix fractional volume, while change in CRVE was directly related to change in the volume fraction of cortex that was interstitium [Vv ₍Int/cortex₎] over the 5-year period. Baseline CRAE or CRVE or changes in these diameters were not related to changes in other anatomical or functional renal endpoints. Conclusions/interpretation Independently of other factors, baseline CRAE correlated with changes in glomerulopathy index, a composite measure of extracellular matrix accumulation in the mesangium and glomerular basement membrane. A narrowing of the CRAE was related to mesangial matrix accumulation. Changes in CRVE were related to changes in Vv ₍Int/cortex₎, a measure of interstitial expansion in persons with type 1 diabetes mellitus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Double-Blind Method</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>kidney diseases</subject><subject>Kidneys</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Microvascular disease</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Retinal blood vessel diameters</subject><subject>Retinal Vessels - pathology</subject><subject>Retinal Vessels - physiopathology</subject><subject>Risk indicators</subject><subject>Type 1 diabetes mellitus</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU2L1TAUhoMozp3RH-BGgyCuqvluu5TBLxhw4QjuQm56Ms3Q29acdOTu_Omm9OqAC1fh5H3Om5PzEvKMszecsfotMsaFrhhnFa-NrOQDsuNKioop0Twku1WueGO-n5FzxFvGmNTKPCZngilZM2F25FeCweU4jdjHmU6BJshxdAO9A0QYaBfdATIkmifqezfeANI4rtf7Ano6wtynaXa5P1LMafF5SWu3S4UYNrioEcaM9GfMPc3HGSg_OQA-IY-CGxCens4Lcv3h_fXlp-rqy8fPl--uKq9MnSupQArDnOz2rW4106bVwpg2GBOahutQKxF41ypeaiN56GAvuYdO-9p0Ul6Q15vtnKYfC2C2h4gehsGNMC1oaymVaplQhXz5D3k7LamsBK0WnNeNbNoC8Q3yaUJMEOyc4sGlo-XMrtnYLRvL1rpkY9cRnp-Ml_0Bur8df8IowKsT4NC7ISQ3-oj3nGhr3XJdOLFxWKSSSLqf8H-vv9iagpusu0nF-NtXwbhkvCkLLf__DTmYsJM</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Klein, R</creator><creator>Knudtson, M. D</creator><creator>Klein, B. E. K</creator><creator>Zinman, B</creator><creator>Gardiner, R</creator><creator>Suissa, S</creator><creator>Sinaiko, A. R</creator><creator>Donnelly, S. M</creator><creator>Goodyer, P</creator><creator>Strand, T</creator><creator>Mauer, M</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes</title><author>Klein, R ; Knudtson, M. D ; Klein, B. E. K ; Zinman, B ; Gardiner, R ; Suissa, S ; Sinaiko, A. R ; Donnelly, S. M ; Goodyer, P ; Strand, T ; Mauer, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-34e3260a3db9595056952669f66f8815f742f1d9416f8631fdeb31ced5c76d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 1 - pathology</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Double-Blind Method</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>kidney diseases</topic><topic>Kidneys</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Microvascular disease</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Retinal blood vessel diameters</topic><topic>Retinal Vessels - pathology</topic><topic>Retinal Vessels - physiopathology</topic><topic>Risk indicators</topic><topic>Type 1 diabetes mellitus</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, R</creatorcontrib><creatorcontrib>Knudtson, M. D</creatorcontrib><creatorcontrib>Klein, B. E. K</creatorcontrib><creatorcontrib>Zinman, B</creatorcontrib><creatorcontrib>Gardiner, R</creatorcontrib><creatorcontrib>Suissa, S</creatorcontrib><creatorcontrib>Sinaiko, A. R</creatorcontrib><creatorcontrib>Donnelly, S. M</creatorcontrib><creatorcontrib>Goodyer, P</creatorcontrib><creatorcontrib>Strand, T</creatorcontrib><creatorcontrib>Mauer, M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, R</au><au>Knudtson, M. D</au><au>Klein, B. E. K</au><au>Zinman, B</au><au>Gardiner, R</au><au>Suissa, S</au><au>Sinaiko, A. R</au><au>Donnelly, S. M</au><au>Goodyer, P</au><au>Strand, T</au><au>Mauer, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>53</volume><issue>8</issue><spage>1638</spage><epage>1646</epage><pages>1638-1646</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims/hypothesis We examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy. Methods Persons with type 1 diabetes mellitus had gradable fundus photographs and renal biopsy data at baseline and 5-year follow-up (n = 234). Retinal arteriolar and venular diameters were measured at baseline and follow-up. Central retinal arteriole equivalent (CRAE) and central retinal venule equivalent (CRVE) were computed. Baseline and 5-year follow-up renal structural variables were assessed by masked electron microscopic morphometric analyses from percutaneous renal biopsy specimens. Variables assessed included: mesangial fractional volume, glomerular basement membrane width, mesangial matrix fractional volume and glomerular basement membrane width composite glomerulopathy index. Results While controlling for other covariates, baseline CRAE was positively associated with change in the glomerulopathy index over the 5-year period. Change in CRAE was inversely related to a change in mesangial matrix fractional volume and abnormal mesangial matrix fractional volume, while change in CRVE was directly related to change in the volume fraction of cortex that was interstitium [Vv ₍Int/cortex₎] over the 5-year period. Baseline CRAE or CRVE or changes in these diameters were not related to changes in other anatomical or functional renal endpoints. Conclusions/interpretation Independently of other factors, baseline CRAE correlated with changes in glomerulopathy index, a composite measure of extracellular matrix accumulation in the mesangium and glomerular basement membrane. A narrowing of the CRAE was related to mesangial matrix accumulation. Changes in CRVE were related to changes in Vv ₍Int/cortex₎, a measure of interstitial expansion in persons with type 1 diabetes mellitus.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20437026</pmid><doi>10.1007/s00125-010-1763-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetologia, 2010-08, Vol.53 (8), p.1638-1646 |
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| subjects | Adolescent Adult Analysis of Variance Associated diseases and complications Biological and medical sciences Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Human Physiology Humans Internal Medicine Kidney - pathology Kidney - physiopathology kidney diseases Kidneys Logistic Models Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Microvascular disease Middle Aged Nephrology. Urinary tract diseases Retinal blood vessel diameters Retinal Vessels - pathology Retinal Vessels - physiopathology Risk indicators Type 1 diabetes mellitus Urinary system involvement in other diseases. Miscellaneous Vertebrates: nervous system and sense organs |
| title | relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes |
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