Directed Self-Assembly of Dipeptides to Form Ultrathin Hydrogel Membranes
The dipeptide amphiphile Fmoc-Leu-Gly-OH has been induced to self-assemble into thin surface-supported hydrogel gel films and gap-spanning hydrogel membranes. The thickness can be closely controlled, giving films/membranes from tens of nanometers to millimeters thick. SEM and TEM have confirmed that...
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| Veröffentlicht in: | Journal of the American Chemical Society 2010-04, Vol.132 (14), p.5130-5136 |
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| container_end_page | 5136 |
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| container_issue | 14 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 132 |
| creator | Johnson, Eleanor K Adams, Dave J Cameron, Petra J |
| description | The dipeptide amphiphile Fmoc-Leu-Gly-OH has been induced to self-assemble into thin surface-supported hydrogel gel films and gap-spanning hydrogel membranes. The thickness can be closely controlled, giving films/membranes from tens of nanometers to millimeters thick. SEM and TEM have confirmed that the dipeptides self-assemble to form fibers, with the membranes resembling a dense “mat” of entangled fibers. The films and membranes were stable once formed. The films could be reversibly dried and collapsed, then reswollen to regain the gel structure. |
| doi_str_mv | 10.1021/ja909579p |
| format | Article |
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The thickness can be closely controlled, giving films/membranes from tens of nanometers to millimeters thick. SEM and TEM have confirmed that the dipeptides self-assemble to form fibers, with the membranes resembling a dense “mat” of entangled fibers. The films and membranes were stable once formed. 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Am. Chem. Soc</addtitle><description>The dipeptide amphiphile Fmoc-Leu-Gly-OH has been induced to self-assemble into thin surface-supported hydrogel gel films and gap-spanning hydrogel membranes. The thickness can be closely controlled, giving films/membranes from tens of nanometers to millimeters thick. SEM and TEM have confirmed that the dipeptides self-assemble to form fibers, with the membranes resembling a dense “mat” of entangled fibers. The films and membranes were stable once formed. The films could be reversibly dried and collapsed, then reswollen to regain the gel structure.</description><subject>Dipeptides - chemical synthesis</subject><subject>Dipeptides - chemistry</subject><subject>Hydrogels - chemical synthesis</subject><subject>Hydrogels - chemistry</subject><subject>Membranes, Artificial</subject><subject>Particle Size</subject><subject>Surface Properties</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0D1PwzAQBmALgWgpDPwB5AUhhsD5K3HGqqW0UhEDdI4c5wKpkjrYydB_T1ChE9PppEev7l5Crhk8MODscWtSSFWStidkzBSHSDEen5IxAPAo0bEYkYsQtsMquWbnZMRBQAJxMiareeXRdljQN6zLaBoCNnm9p66k86rFtqsKDLRzdOF8Qzd15033We3ocl9494E1fRm8NzsMl-SsNHXAq985IZvF0_tsGa1fn1ez6ToyQkMXcZUqZNyCAi1LWWhu82K4GaWWiTG5YpopEHEBTHNVlMhQpGCt5DzmLOViQu4Oua13Xz2GLmuqYLGuhyNcH7JECCllzJNB3h-k9S4Ej2XW-qoxfp8xyH6Ky47FDfbmN7XPGyyO8q-pAdwegLEh27re74Yn_wn6Bhatco8</recordid><startdate>20100414</startdate><enddate>20100414</enddate><creator>Johnson, Eleanor K</creator><creator>Adams, Dave J</creator><creator>Cameron, Petra J</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100414</creationdate><title>Directed Self-Assembly of Dipeptides to Form Ultrathin Hydrogel Membranes</title><author>Johnson, Eleanor K ; Adams, Dave J ; Cameron, Petra J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-2595e12c05084f4d82cbd520e4847aab51815036d01825dfe1e390cc422621923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Dipeptides - chemical synthesis</topic><topic>Dipeptides - chemistry</topic><topic>Hydrogels - chemical synthesis</topic><topic>Hydrogels - chemistry</topic><topic>Membranes, Artificial</topic><topic>Particle Size</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Eleanor K</creatorcontrib><creatorcontrib>Adams, Dave J</creatorcontrib><creatorcontrib>Cameron, Petra J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Eleanor K</au><au>Adams, Dave J</au><au>Cameron, Petra J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Directed Self-Assembly of Dipeptides to Form Ultrathin Hydrogel Membranes</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. 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| ispartof | Journal of the American Chemical Society, 2010-04, Vol.132 (14), p.5130-5136 |
| issn | 0002-7863 1520-5126 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Dipeptides - chemical synthesis Dipeptides - chemistry Hydrogels - chemical synthesis Hydrogels - chemistry Membranes, Artificial Particle Size Surface Properties |
| title | Directed Self-Assembly of Dipeptides to Form Ultrathin Hydrogel Membranes |
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