Ropivacaine-Induced Peripheral Nerve Injection Injury in the Rodent Model

Intraneural administration of local anesthetics has been associated with nerve damage. We undertook the present study to investigate histological changes induced by ropivacaine injection into rat sciatic nerve. Fifty-four adult male Lewis rats were randomly distributed into 9 groups, 6 animals per g...

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Veröffentlicht in:	Anesthesia and analgesia 2010-07, Vol.111 (1), p.214-220
Hauptverfasser:	Whitlock, Elizabeth L., Brenner, Michael J., Fox, Ida K., Moradzadeh, Arash, Hunter, Daniel A., Mackinnon, Susan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - administration & dosage Amides - toxicity Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local - administration & dosage Anesthetics, Local - toxicity Animals Axons - pathology Biological and medical sciences Demyelinating Diseases - chemically induced Demyelinating Diseases - pathology Immunohistochemistry Injections Male Medical sciences Microscopy, Electron Nerve Regeneration Peripheral Nerves - drug effects Peripheral Nerves - pathology Peripheral Nerves - ultrastructure Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - pathology Rats Rats, Inbred Lew Sciatic Nerve - pathology Wallerian Degeneration - chemically induced Wallerian Degeneration - pathology
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