Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii
Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptid...
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Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2010-06, Vol.73 (6), p.1027-1032 |
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creator | Pavlaskova, Katerina Nedved, Jan Kuzma, Marek Zabka, Martin Sulc, Miroslav Sklenar, Jan Novak, Petr Benada, Oldrich Kofronova, Olga Hajduch, Marian Derrick, Peter J Lemr, Karel Jegorov, Alexandr Havlicek, Vladimir |
description | Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species. |
doi_str_mv | 10.1021/np900472c |
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In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np900472c</identifier><identifier>PMID: 20509707</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Amino Acid Sequence ; Animals ; Applied microbiology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Humans ; Mice ; Microbial Sensitivity Tests ; Microbiology ; Miscellaneous ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - isolation & purification ; Pseudallescheria - chemistry ; Pseudallescheria - pathogenicity</subject><ispartof>Journal of natural products (Washington, D.C.), 2010-06, Vol.73 (6), p.1027-1032</ispartof><rights>Copyright © 2010 American Chemical Society and American Society of Pharmacognosy and American Society of Pharmacognosy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a410t-126abedfaf5091a6e2123a227fd8d5ef13229626aef982d60a41e93cc6a6b0db3</citedby><cites>FETCH-LOGICAL-a410t-126abedfaf5091a6e2123a227fd8d5ef13229626aef982d60a41e93cc6a6b0db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np900472c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np900472c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22974143$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20509707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavlaskova, Katerina</creatorcontrib><creatorcontrib>Nedved, Jan</creatorcontrib><creatorcontrib>Kuzma, Marek</creatorcontrib><creatorcontrib>Zabka, Martin</creatorcontrib><creatorcontrib>Sulc, Miroslav</creatorcontrib><creatorcontrib>Sklenar, Jan</creatorcontrib><creatorcontrib>Novak, Petr</creatorcontrib><creatorcontrib>Benada, Oldrich</creatorcontrib><creatorcontrib>Kofronova, Olga</creatorcontrib><creatorcontrib>Hajduch, Marian</creatorcontrib><creatorcontrib>Derrick, Peter J</creatorcontrib><creatorcontrib>Lemr, Karel</creatorcontrib><creatorcontrib>Jegorov, Alexandr</creatorcontrib><creatorcontrib>Havlicek, Vladimir</creatorcontrib><title>Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Peptides, Cyclic - chemistry</subject><subject>Peptides, Cyclic - isolation & purification</subject><subject>Pseudallescheria - chemistry</subject><subject>Pseudallescheria - pathogenicity</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M1KxDAQB_Agiq4fB19AchERrE6SNt0eZfELBBfUc5kmE4102zVpD-sTePYRfRK7uOrFUw7zm_-EP2P7Ak4FSHHWzAuANJdmjY1EJiHRILN1NgKhVaLGOt1i2zG-AICCIttkWxIyKHLIR-xp8owBTUfBv2Hn24a3jk8j9RbNwtS-ifz88_3j4oQjv-99R8v5ZDkxfErzzluKfBpa2xuyvFqsduuaonkeQpFX7cJ6v8s2HNaR9lbvDnu8vHiYXCe3d1c3k_PbBFMBXSKkxoqsQzd8UKAmKaRCKXNnxzYjJ5SUhR4QuWIsrYZhjQpljEZdga3UDjv6zp2H9rWn2JUzHw3VNTbU9rHMlUpTUDIb5PG3NKGNMZAr58HPMCxKAeWy1vK31sEerFL7akb2V_70OIDDFcBosHYBG-Pjn5NFnopU_Tk0sXxp-9AMZfxz8As7DYy7</recordid><startdate>20100625</startdate><enddate>20100625</enddate><creator>Pavlaskova, Katerina</creator><creator>Nedved, Jan</creator><creator>Kuzma, Marek</creator><creator>Zabka, Martin</creator><creator>Sulc, Miroslav</creator><creator>Sklenar, Jan</creator><creator>Novak, Petr</creator><creator>Benada, Oldrich</creator><creator>Kofronova, Olga</creator><creator>Hajduch, Marian</creator><creator>Derrick, Peter J</creator><creator>Lemr, Karel</creator><creator>Jegorov, Alexandr</creator><creator>Havlicek, Vladimir</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100625</creationdate><title>Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii</title><author>Pavlaskova, Katerina ; Nedved, Jan ; Kuzma, Marek ; Zabka, Martin ; Sulc, Miroslav ; Sklenar, Jan ; Novak, Petr ; Benada, Oldrich ; Kofronova, Olga ; Hajduch, Marian ; Derrick, Peter J ; Lemr, Karel ; Jegorov, Alexandr ; Havlicek, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a410t-126abedfaf5091a6e2123a227fd8d5ef13229626aef982d60a41e93cc6a6b0db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Peptides, Cyclic - chemistry</topic><topic>Peptides, Cyclic - isolation & purification</topic><topic>Pseudallescheria - chemistry</topic><topic>Pseudallescheria - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pavlaskova, Katerina</creatorcontrib><creatorcontrib>Nedved, Jan</creatorcontrib><creatorcontrib>Kuzma, Marek</creatorcontrib><creatorcontrib>Zabka, Martin</creatorcontrib><creatorcontrib>Sulc, Miroslav</creatorcontrib><creatorcontrib>Sklenar, Jan</creatorcontrib><creatorcontrib>Novak, Petr</creatorcontrib><creatorcontrib>Benada, Oldrich</creatorcontrib><creatorcontrib>Kofronova, Olga</creatorcontrib><creatorcontrib>Hajduch, Marian</creatorcontrib><creatorcontrib>Derrick, Peter J</creatorcontrib><creatorcontrib>Lemr, Karel</creatorcontrib><creatorcontrib>Jegorov, Alexandr</creatorcontrib><creatorcontrib>Havlicek, Vladimir</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pavlaskova, Katerina</au><au>Nedved, Jan</au><au>Kuzma, Marek</au><au>Zabka, Martin</au><au>Sulc, Miroslav</au><au>Sklenar, Jan</au><au>Novak, Petr</au><au>Benada, Oldrich</au><au>Kofronova, Olga</au><au>Hajduch, Marian</au><au>Derrick, Peter J</au><au>Lemr, Karel</au><au>Jegorov, Alexandr</au><au>Havlicek, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2010-06-25</date><risdate>2010</risdate><volume>73</volume><issue>6</issue><spage>1027</spage><epage>1032</epage><pages>1027-1032</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. 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subjects | Amino Acid Sequence Animals Applied microbiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Humans Mice Microbial Sensitivity Tests Microbiology Miscellaneous Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Pseudallescheria - chemistry Pseudallescheria - pathogenicity |
title | Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii |
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