Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii

Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptid...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2010-06, Vol.73 (6), p.1027-1032
Hauptverfasser: Pavlaskova, Katerina, Nedved, Jan, Kuzma, Marek, Zabka, Martin, Sulc, Miroslav, Sklenar, Jan, Novak, Petr, Benada, Oldrich, Kofronova, Olga, Hajduch, Marian, Derrick, Peter J, Lemr, Karel, Jegorov, Alexandr, Havlicek, Vladimir
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container_issue 6
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container_title Journal of natural products (Washington, D.C.)
container_volume 73
creator Pavlaskova, Katerina
Nedved, Jan
Kuzma, Marek
Zabka, Martin
Sulc, Miroslav
Sklenar, Jan
Novak, Petr
Benada, Oldrich
Kofronova, Olga
Hajduch, Marian
Derrick, Peter J
Lemr, Karel
Jegorov, Alexandr
Havlicek, Vladimir
description Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species.
doi_str_mv 10.1021/np900472c
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subjects Amino Acid Sequence
Animals
Applied microbiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Mice
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Pseudallescheria - chemistry
Pseudallescheria - pathogenicity
title Characterization of Pseudacyclins A−E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii
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