three-dimensional structure of an intact monoclonal antibody for canine lymphoma

CRYSTAL structures of Fab antibody fragments determined by X-ray diffraction characteristically feature four-domain, beta-barrel arrangements. A human antibody Fc fragment has also been found to have four beta-barrel domains. The structures of a few intact antibodies have been solved: in two myeloma...

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Veröffentlicht in:Nature (London) 1992-11, Vol.360 (6402), p.369-372
Hauptverfasser: Harris, L.J, Larson, S.B, Hasel, K.W, Day, J, Greenwood, A, McPherson, A
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Sprache:eng
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