Sampling the N-terminal proteome of human blood

The proteomes of blood plasma and serum represent a potential gold mine of biological and diagnostic information, but challenges such as dynamic range of protein concentration have hampered efforts to unlock this resource. Here we present a method to label and isolate N-terminal peptides from human...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (10), p.4561-4566
Hauptverfasser:	Wildes, David, Wells, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological markers Biological Sciences Blood Blood plasma Blood proteins Blood Proteins - analysis Blood Proteins - chemistry Chromatography, Liquid Coagulation Enzymes Humans Mass Spectrometry Mass spectroscopy Peptide Fragments - analysis Peptide Fragments - isolation & purification Peptides Plasma Proteins Proteome - analysis Proteome - chemistry Proteomes Proteomics Proteomics - methods Reproducibility of Results Staining and Labeling - methods
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