IFN-γ-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer
Abstract De novo expression of B7-1 impaired tumorigenicity of TRAMP-C2 mouse prostate adenocarcinoma (TRAMP-C2/B7), but it did not elicit a protective response against TRAMP-C2 parental tumor, unless after in vitro treatment with IFN-γ. TRAMP-C2 cells secrete TGF-β and show low MHC-I expression. Tr...
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Veröffentlicht in: | Vaccine 2010-04, Vol.28 (20), p.3548-3557 |
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Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract De novo expression of B7-1 impaired tumorigenicity of TRAMP-C2 mouse prostate adenocarcinoma (TRAMP-C2/B7), but it did not elicit a protective response against TRAMP-C2 parental tumor, unless after in vitro treatment with IFN-γ. TRAMP-C2 cells secrete TGF-β and show low MHC-I expression. Treatment with IFN-γ increased MHC-I expression by induction of some APM components and antagonizing the immunosuppressant activity of TGF-β. Thus, immunization with TRAMP-C2/B7 conferred protection against TRAMP-C2-derived tumors in function of the IFN-γ-mediated fine-tuned modulation of either APM expression or TGF-β signaling. To explore possible clinical translation, we delivered IFN-γ to TRAMP-C2 tumor site by means of genetically engineered MSCs secreting IFN-γ. |
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ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2010.03.007 |