Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness

Protein kinase C-alpha (PKCalpha) was recently reported to increase myocardial stiffness, an effect that was proposed to be due to phosphorylation of two highly conserved sites (S11878 and S12022) within the proline-glutamic acid-valine-lysine (PEVK) rich spring element of titin. To test this propos...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2010-05, Vol.48 (5), p.972-978
Hauptverfasser:	Hudson, Bryan D, Hidalgo, Carlos G, Gotthardt, Michael, Granzier, Henk L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Connectin Diastole - physiology Exons - genetics Heart - drug effects Humans Male Mice Mice, Knockout Muscle Proteins - genetics Muscle Proteins - metabolism Myocardium - metabolism Phosphorylation - drug effects Protein Kinase C-alpha - pharmacology Protein Kinases - genetics Protein Kinases - metabolism
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