Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions
Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tabl...
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| Veröffentlicht in: | Pharmaceutical development and technology 2010-03, Vol.15 (2), p.162-7 |
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| container_title | Pharmaceutical development and technology |
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| creator | Lamas, Maria Celina Leonardi, Darío Lambri, Osvaldo A Bassani, Georgina Barrera, María G Bolmaro, Raúl E Salomon, Claudio J |
| description | Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration. |
| doi_str_mv | 10.1080/10837450903085400 |
| format | Article |
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| ispartof | Pharmaceutical development and technology, 2010-03, Vol.15 (2), p.162-7 |
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| subjects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Diclofenac - administration & dosage Diclofenac - chemistry Drug Carriers - chemistry Drug Stability Drug Storage Povidone - chemistry Solubility Tablets Time Factors |
| title | Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions |
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