Opposite sensitivity to the antiproliferative action of interferon-α and granulocyte-macrophage colony-stimulating factor in monoblastic U937 cells

Three variants of the human monoblastic cell line U937 with different degrees of sensitivity to the antiproliferative action of interferon-alpha (IFN-alpha were examined for phenotypic differences. The highly IFN-sensitive variant U937-V expressed twice as many IFN-alpha binding sites as both its IF...

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Veröffentlicht in:	Journal of interferon research 1992-10, Vol.12 (5), p.369-376
Hauptverfasser:	KLOKE, O, MORITZ, T, KUMMER, G, HUST, H, ROSS, B, SEEBER, S, NIEDERLE, N
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - biosynthesis 2',5'-Oligoadenylate Synthetase - metabolism Biological and medical sciences Cell Differentiation - drug effects Cell Division - drug effects Cell physiology Enzyme Induction - drug effects Fundamental and applied biological sciences. Psychology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Humans Infant, Newborn Interferon-alpha - metabolism Interferon-alpha - pharmacology Interferon-alpha - therapeutic use Interferon-gamma - pharmacology Leukemia, Monocytic, Acute - drug therapy Molecular and cellular biology Phenotype Protein Binding Receptors, Interferon - metabolism Responses to growth factors, tumor promotors, other factors Sensitivity and Specificity Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology
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