ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells
Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process. We further reveal that reactive oxygen species (ROS...
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| Veröffentlicht in: | FEBS letters 2010-06, Vol.584 (11), p.2291-2297 |
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| creator | Li, Zhushi Shi, Kejian Guan, Liying Cao, Tingming Jiang, Qian Yang, Yang Xu, Caimin |
| description | Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process. We further reveal that reactive oxygen species (ROS), especially superoxide radicals, play a crucial role in selenite-induced MnSOD upregulation, with extracellular regulated kinase (ERK) and p53 closely implicated. Specifically, ERK2 translocates into the nucleus driven by ROS, where it directly phosphorylates p53, leading to dissociation of p53 from its inhibitory protein mouse double minute 2 (MDM2). Active p53 directly mediates the expression of MnSOD, serving as the link between ERK2 translocation and MnSOD upregulation. |
| doi_str_mv | 10.1016/j.febslet.2010.03.040 |
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We further reveal that reactive oxygen species (ROS), especially superoxide radicals, play a crucial role in selenite-induced MnSOD upregulation, with extracellular regulated kinase (ERK) and p53 closely implicated. Specifically, ERK2 translocates into the nucleus driven by ROS, where it directly phosphorylates p53, leading to dissociation of p53 from its inhibitory protein mouse double minute 2 (MDM2). Active p53 directly mediates the expression of MnSOD, serving as the link between ERK2 translocation and MnSOD upregulation.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2010.03.040</identifier><identifier>PMID: 20353787</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>acute promyelocytic leukemia ; APL ; Apoptosis - drug effects ; Cell Line, Tumor ; ERK ; Extracellular regulated kinase ; Genes, p53 ; Humans ; Manganese superoxide dismutase ; MDM2 ; MnSOD ; mouse double minute 2 ; Nuclear translocation ; p53 ; Protein Transport - genetics ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; ROS ; Sodium Selenite - pharmacology ; Superoxide Dismutase - genetics ; Superoxide Dismutase - metabolism ; Superoxides - metabolism ; Tumor Suppressor Protein p53 - genetics ; Up-Regulation - drug effects</subject><ispartof>FEBS letters, 2010-06, Vol.584 (11), p.2291-2297</ispartof><rights>2010 Federation of European Biochemical Societies</rights><rights>FEBS Letters 584 (2010) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5427-90514836ca3ec99348c7c4320619e0422e04a53c6c73fed92439ec59357980523</citedby><cites>FETCH-LOGICAL-c5427-90514836ca3ec99348c7c4320619e0422e04a53c6c73fed92439ec59357980523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2010.03.040$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2010.03.040$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,1418,1434,3551,27929,27930,45579,45580,46000,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20353787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhushi</creatorcontrib><creatorcontrib>Shi, Kejian</creatorcontrib><creatorcontrib>Guan, Liying</creatorcontrib><creatorcontrib>Cao, Tingming</creatorcontrib><creatorcontrib>Jiang, Qian</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Xu, Caimin</creatorcontrib><title>ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process. We further reveal that reactive oxygen species (ROS), especially superoxide radicals, play a crucial role in selenite-induced MnSOD upregulation, with extracellular regulated kinase (ERK) and p53 closely implicated. Specifically, ERK2 translocates into the nucleus driven by ROS, where it directly phosphorylates p53, leading to dissociation of p53 from its inhibitory protein mouse double minute 2 (MDM2). Active p53 directly mediates the expression of MnSOD, serving as the link between ERK2 translocation and MnSOD upregulation.</description><subject>acute promyelocytic leukemia</subject><subject>APL</subject><subject>Apoptosis - drug effects</subject><subject>Cell Line, Tumor</subject><subject>ERK</subject><subject>Extracellular regulated kinase</subject><subject>Genes, p53</subject><subject>Humans</subject><subject>Manganese superoxide dismutase</subject><subject>MDM2</subject><subject>MnSOD</subject><subject>mouse double minute 2</subject><subject>Nuclear translocation</subject><subject>p53</subject><subject>Protein Transport - genetics</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>ROS</subject><subject>Sodium Selenite - pharmacology</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxides - metabolism</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Up-Regulation - drug effects</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9vFCEUxYnR2LX6ETS8-TQrcJk_PBlbt9ZY3aSrz4Qyd1o2s8MUmGq_vUxm9VVfIFzOPVx-h5DXnK0549W7_brDm9hjWguWawzWTLInZMWbGgqQVfOUrBjjsihrBSfkRYx7ls8NV8_JiWBQQt3UK_LrerujPZo20uTp12G3_UinMeDt1Jvk_EDTXfDT7R3dXH8RNAUzxN7b5coMLR1LoMYm97CU3EAj9ji4hIUb2sliS83ox-Sji9R39NuZpBb7Pr4kzzrTR3x13E_Jj4vN9_PL4mr76fP5h6vCllLUhWIllw1U1gBapUA2trYSBKu4QiaFyIspwVa2hg5bJSQotKWC_O2GlQJOydvFdwz-fsKY9MHFeQIzoJ-irgFA8ariWVkuSht8jAE7PQZ3MOFRc6Zn5nqvj8z1zFwz0Jl57ntzfGG6OWD7t-sP5Cy4XAQ_XY-P_-eqLzZnYjcHOOfHc3SiYrPV-8UKM7IHh0FH63DImF1Am3Tr3T-m_Q2v8akt</recordid><startdate>20100603</startdate><enddate>20100603</enddate><creator>Li, Zhushi</creator><creator>Shi, Kejian</creator><creator>Guan, Liying</creator><creator>Cao, Tingming</creator><creator>Jiang, Qian</creator><creator>Yang, Yang</creator><creator>Xu, Caimin</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100603</creationdate><title>ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells</title><author>Li, Zhushi ; Shi, Kejian ; Guan, Liying ; Cao, Tingming ; Jiang, Qian ; Yang, Yang ; Xu, Caimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5427-90514836ca3ec99348c7c4320619e0422e04a53c6c73fed92439ec59357980523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acute promyelocytic leukemia</topic><topic>APL</topic><topic>Apoptosis - drug effects</topic><topic>Cell Line, Tumor</topic><topic>ERK</topic><topic>Extracellular regulated kinase</topic><topic>Genes, p53</topic><topic>Humans</topic><topic>Manganese superoxide dismutase</topic><topic>MDM2</topic><topic>MnSOD</topic><topic>mouse double minute 2</topic><topic>Nuclear translocation</topic><topic>p53</topic><topic>Protein Transport - genetics</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>ROS</topic><topic>Sodium Selenite - pharmacology</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Superoxides - metabolism</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhushi</creatorcontrib><creatorcontrib>Shi, Kejian</creatorcontrib><creatorcontrib>Guan, Liying</creatorcontrib><creatorcontrib>Cao, Tingming</creatorcontrib><creatorcontrib>Jiang, Qian</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Xu, Caimin</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhushi</au><au>Shi, Kejian</au><au>Guan, Liying</au><au>Cao, Tingming</au><au>Jiang, Qian</au><au>Yang, Yang</au><au>Xu, Caimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2010-06-03</date><risdate>2010</risdate><volume>584</volume><issue>11</issue><spage>2291</spage><epage>2297</epage><pages>2291-2297</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process. We further reveal that reactive oxygen species (ROS), especially superoxide radicals, play a crucial role in selenite-induced MnSOD upregulation, with extracellular regulated kinase (ERK) and p53 closely implicated. Specifically, ERK2 translocates into the nucleus driven by ROS, where it directly phosphorylates p53, leading to dissociation of p53 from its inhibitory protein mouse double minute 2 (MDM2). Active p53 directly mediates the expression of MnSOD, serving as the link between ERK2 translocation and MnSOD upregulation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>20353787</pmid><doi>10.1016/j.febslet.2010.03.040</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acute promyelocytic leukemia APL Apoptosis - drug effects Cell Line, Tumor ERK Extracellular regulated kinase Genes, p53 Humans Manganese superoxide dismutase MDM2 MnSOD mouse double minute 2 Nuclear translocation p53 Protein Transport - genetics Reactive oxygen species Reactive Oxygen Species - metabolism ROS Sodium Selenite - pharmacology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxides - metabolism Tumor Suppressor Protein p53 - genetics Up-Regulation - drug effects |
| title | ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells |
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