Cardiac oxidative stress is involved in heart failure induced by thiamine deprivation in rats

Thiamine is an important cofactor of metabolic enzymes, and its deficiency leads to cardiovascular dysfunction. First, we characterized the metabolic status measuring resting oxygen consumption rate and lactate blood concentration after 35 days of thiamine deficiency (TD). The results pointed to a d...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2010-06, Vol.298 (6), p.H2039-H2045
Hauptverfasser:	Gioda, Carolina Rosa, de Oliveira Barreto, Tatiane, Prímola-Gomes, Thales Nicolau, de Lima, Daniel Carvalho, Campos, Paula Peixoto, Capettini, Luciano dos Santos Aggunn, Lauton-Santos, Sandra, Vasconcelos, Anilton César, Coimbra, Cândido C, Lemos, Virginia Soares, Pesquero, Jorge L, Cruz, Jader S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Catalase - metabolism Disease Models, Animal Glutathione Peroxidase - metabolism Heart - physiopathology Heart failure Heart Failure - etiology Heart Failure - physiopathology Lactates - blood Male Metabolism Myocardium - metabolism Myocardium - pathology Oxidative Stress - physiology Oxygen Oxygen Consumption - physiology Physiology Proteins Rats Rats, Wistar Reactive Oxygen Species - metabolism Rodents Superoxide Dismutase - metabolism Thiamine Deficiency - complications Vitamin B Vitamin deficiency
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