Dynamic vs. fixed bag filling: Impact on cardiac output rebreathing protocol
Abstract A main purpose of this study was to compare the repeatability (2.77 multiplied by the within-subject SD) between two different rebreathing protocols on cardiac output ( Q ˙ ) , pulmonary diffusing capacity for carbon monoxide (DLCO ) and nitric oxide (DLNO ), and pulmonary capillary blood v...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2010-04, Vol.171 (1), p.22-30 |
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| creator | Zavorsky, Gerald S Beck, Kenneth C Cass, Lauren M Artal, Raul Wagner, Peter D |
| description | Abstract A main purpose of this study was to compare the repeatability (2.77 multiplied by the within-subject SD) between two different rebreathing protocols on cardiac output ( Q ˙ ) , pulmonary diffusing capacity for carbon monoxide (DLCO ) and nitric oxide (DLNO ), and pulmonary capillary blood volume (Vc). This study compared two bag volume conditions [Fixed Bag Volume (FBV) = BV fixed at 60% of forced vital capacity; Dynamic Bag Volume (DBV) = BV matched to tidal volume at each stage of exercise]. Ten females (age = 27 ± 8 years; V ˙ O 2 , peak = 2.5 ± 0.6 L/min ) had measurements at rest (12%), 50%, 88%, and 100% of V ˙ O 2 , peak on two study days in a balanced, crossover design. Neither the slope nor intercept of Q ˙ vs. V ˙ O 2 were different between FBV or DBV. The slope of DLCO vs. Q ˙ was the same but intercept was higher for FBV. The BV affected the slope and the intercept between DLNO vs. Q ˙ ( p < 0.05). The repeatability was similar between both protocols for Q ˙ (2.8–3.4 l/min) and DLNO (33–42 ml/min/mmHg) regardless of exercise intensity. However, the measurement error was lower for Vc when using the FBV protocol ( p < 0.05). This study shows that the pattern of BV used during rebreathing maneuvers affects DLNO vs. Q ˙ relation more than it affects DLCO and Vc vs. Q ˙ . In addition FBV protocol provides more repeatable Vc measurements at any exercise stage compared to the DBV protocol. |
| doi_str_mv | 10.1016/j.resp.2010.01.006 |
| format | Article |
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This study compared two bag volume conditions [Fixed Bag Volume (FBV) = BV fixed at 60% of forced vital capacity; Dynamic Bag Volume (DBV) = BV matched to tidal volume at each stage of exercise]. Ten females (age = 27 ± 8 years; V ˙ O 2 , peak = 2.5 ± 0.6 L/min ) had measurements at rest (12%), 50%, 88%, and 100% of V ˙ O 2 , peak on two study days in a balanced, crossover design. Neither the slope nor intercept of Q ˙ vs. V ˙ O 2 were different between FBV or DBV. The slope of DLCO vs. Q ˙ was the same but intercept was higher for FBV. The BV affected the slope and the intercept between DLNO vs. Q ˙ ( p < 0.05). The repeatability was similar between both protocols for Q ˙ (2.8–3.4 l/min) and DLNO (33–42 ml/min/mmHg) regardless of exercise intensity. However, the measurement error was lower for Vc when using the FBV protocol ( p < 0.05). This study shows that the pattern of BV used during rebreathing maneuvers affects DLNO vs. Q ˙ relation more than it affects DLCO and Vc vs. Q ˙ . 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Psychology ; Humans ; Measurement error ; Medical Education ; Middle Aged ; Nitric Oxide - blood ; Oxygen - blood ; Oxygen Consumption ; Pulmonary Diffusing Capacity ; Pulmonary/Respiratory ; Rebreathing ; Regression Analysis ; Respiratory Function Tests - methods ; Respiratory Mechanics - physiology ; Rest ; Vertebrates: respiratory system ; Young Adult</subject><ispartof>Respiratory physiology & neurobiology, 2010-04, Vol.171 (1), p.22-30</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. 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This study compared two bag volume conditions [Fixed Bag Volume (FBV) = BV fixed at 60% of forced vital capacity; Dynamic Bag Volume (DBV) = BV matched to tidal volume at each stage of exercise]. Ten females (age = 27 ± 8 years; V ˙ O 2 , peak = 2.5 ± 0.6 L/min ) had measurements at rest (12%), 50%, 88%, and 100% of V ˙ O 2 , peak on two study days in a balanced, crossover design. Neither the slope nor intercept of Q ˙ vs. V ˙ O 2 were different between FBV or DBV. The slope of DLCO vs. Q ˙ was the same but intercept was higher for FBV. The BV affected the slope and the intercept between DLNO vs. Q ˙ ( p < 0.05). The repeatability was similar between both protocols for Q ˙ (2.8–3.4 l/min) and DLNO (33–42 ml/min/mmHg) regardless of exercise intensity. However, the measurement error was lower for Vc when using the FBV protocol ( p < 0.05). This study shows that the pattern of BV used during rebreathing maneuvers affects DLNO vs. Q ˙ relation more than it affects DLCO and Vc vs. Q ˙ . In addition FBV protocol provides more repeatable Vc measurements at any exercise stage compared to the DBV protocol.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carbon Monoxide - blood</subject><subject>Cardiac output</subject><subject>Cardiac Output - physiology</subject><subject>Diffusing capacity</subject><subject>Exercise</subject><subject>Exercise Test - methods</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Measurement error</subject><subject>Medical Education</subject><subject>Middle Aged</subject><subject>Nitric Oxide - blood</subject><subject>Oxygen - blood</subject><subject>Oxygen Consumption</subject><subject>Pulmonary Diffusing Capacity</subject><subject>Pulmonary/Respiratory</subject><subject>Rebreathing</subject><subject>Regression Analysis</subject><subject>Respiratory Function Tests - methods</subject><subject>Respiratory Mechanics - physiology</subject><subject>Rest</subject><subject>Vertebrates: respiratory system</subject><subject>Young Adult</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVuL1TAQgIMo7kX_gA_SF_GpddI0l4osyK6XhQM-uO8hTaZrjm1Tk3bx_HtTzlHBB_MyQ_LNTPiGkBcUKgpUvNlXEdNc1ZAvgFYA4hE5p0qqknLaPs45F23ZQqPOyEVKewAqqWRPyVkNoLiq5TnZ3RwmM3pbPKSq6P1PdEVn7nM2DH66f1vcjrOxSxGmwprovLFFWJd5XYqIXUSzfMtUMcewBBuGZ-RJb4aEz0_xktx9_HB3_bncffl0e_1-V9qmgaXsLHJloc0RKGM9ZVxwEE7WKgPMCSpa0_C-yy-qc7LpkYuuNq000knBLsnrY9s898eKadGjTxaHwUwY1qQlY6ylvGkzWR9JG0NKEXs9Rz-aeNAU9OZQ7_XmUG8ONVCdHeail6f2azei-1PyW1oGXp0Ak6wZ-mgm69NfrhYgm0Zl7t2Rw-ziwWPUyXqcLDof0S7aBf__f1z9U27zTnye-B0PmPZhjVO2rKlOtQb9ddv2tmwK25GK_QIzVaPN</recordid><startdate>20100415</startdate><enddate>20100415</enddate><creator>Zavorsky, Gerald S</creator><creator>Beck, Kenneth C</creator><creator>Cass, Lauren M</creator><creator>Artal, Raul</creator><creator>Wagner, Peter D</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100415</creationdate><title>Dynamic vs. fixed bag filling: Impact on cardiac output rebreathing protocol</title><author>Zavorsky, Gerald S ; Beck, Kenneth C ; Cass, Lauren M ; Artal, Raul ; Wagner, Peter D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-bce58c09bce0133f1356506d728c443d6169a45fbf138bd74fe56b2a97a7d763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carbon Monoxide - blood</topic><topic>Cardiac output</topic><topic>Cardiac Output - physiology</topic><topic>Diffusing capacity</topic><topic>Exercise</topic><topic>Exercise Test - methods</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Measurement error</topic><topic>Medical Education</topic><topic>Middle Aged</topic><topic>Nitric Oxide - blood</topic><topic>Oxygen - blood</topic><topic>Oxygen Consumption</topic><topic>Pulmonary Diffusing Capacity</topic><topic>Pulmonary/Respiratory</topic><topic>Rebreathing</topic><topic>Regression Analysis</topic><topic>Respiratory Function Tests - methods</topic><topic>Respiratory Mechanics - physiology</topic><topic>Rest</topic><topic>Vertebrates: respiratory system</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zavorsky, Gerald S</creatorcontrib><creatorcontrib>Beck, Kenneth C</creatorcontrib><creatorcontrib>Cass, Lauren M</creatorcontrib><creatorcontrib>Artal, Raul</creatorcontrib><creatorcontrib>Wagner, Peter D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zavorsky, Gerald S</au><au>Beck, Kenneth C</au><au>Cass, Lauren M</au><au>Artal, Raul</au><au>Wagner, Peter D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic vs. fixed bag filling: Impact on cardiac output rebreathing protocol</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2010-04-15</date><risdate>2010</risdate><volume>171</volume><issue>1</issue><spage>22</spage><epage>30</epage><pages>22-30</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><abstract>Abstract A main purpose of this study was to compare the repeatability (2.77 multiplied by the within-subject SD) between two different rebreathing protocols on cardiac output ( Q ˙ ) , pulmonary diffusing capacity for carbon monoxide (DLCO ) and nitric oxide (DLNO ), and pulmonary capillary blood volume (Vc). This study compared two bag volume conditions [Fixed Bag Volume (FBV) = BV fixed at 60% of forced vital capacity; Dynamic Bag Volume (DBV) = BV matched to tidal volume at each stage of exercise]. Ten females (age = 27 ± 8 years; V ˙ O 2 , peak = 2.5 ± 0.6 L/min ) had measurements at rest (12%), 50%, 88%, and 100% of V ˙ O 2 , peak on two study days in a balanced, crossover design. Neither the slope nor intercept of Q ˙ vs. V ˙ O 2 were different between FBV or DBV. The slope of DLCO vs. Q ˙ was the same but intercept was higher for FBV. The BV affected the slope and the intercept between DLNO vs. Q ˙ ( p < 0.05). The repeatability was similar between both protocols for Q ˙ (2.8–3.4 l/min) and DLNO (33–42 ml/min/mmHg) regardless of exercise intensity. However, the measurement error was lower for Vc when using the FBV protocol ( p < 0.05). This study shows that the pattern of BV used during rebreathing maneuvers affects DLNO vs. Q ˙ relation more than it affects DLCO and Vc vs. Q ˙ . In addition FBV protocol provides more repeatable Vc measurements at any exercise stage compared to the DBV protocol.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20085827</pmid><doi>10.1016/j.resp.2010.01.006</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Carbon Monoxide - blood Cardiac output Cardiac Output - physiology Diffusing capacity Exercise Exercise Test - methods Female Fundamental and applied biological sciences. Psychology Humans Measurement error Medical Education Middle Aged Nitric Oxide - blood Oxygen - blood Oxygen Consumption Pulmonary Diffusing Capacity Pulmonary/Respiratory Rebreathing Regression Analysis Respiratory Function Tests - methods Respiratory Mechanics - physiology Rest Vertebrates: respiratory system Young Adult |
| title | Dynamic vs. fixed bag filling: Impact on cardiac output rebreathing protocol |
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