Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha

Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin in...

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Veröffentlicht in:	FEBS letters 2010-06, Vol.584 (11), p.2485-2490
Hauptverfasser:	Rechtman, Maya Mouler, Har-Noy, Ofir, Bar-Yishay, Iddo, Fishman, Sigal, Adamovich, Yaarit, Shaul, Yosef, Halpern, Zamir, Shlomai, Amir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - metabolism Biochemical Phenomena Curcumin - metabolism Down-Regulation Gene Expression Gluconeogenesis - genetics Hepatitis B - genetics Hepatitis B - metabolism Hepatitis B - virology Hepatitis B virus - genetics Hepatitis B virus - metabolism Humans Liver - metabolism Liver - virology Pepsin A
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