Longitudinal study of serum thyroid hormone levels during normal pregnancy
We undertook a prospective longitudinal study of thyroid function in 60 normal pregnant women and measured serum concentrations of T 4, triiodothyronine (T 3), T-uptake, thyroxine binding globulin (TBG), free thyroxine index (FTI), free T 4, albumin and thyrotropin (TSH). From these data we establis...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 1992-07, Vol.38 (3), p.171-179 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | O'Leary, P.C. Boyne, P. Atkinson, G. Mileham, K.-J. James, I. |
| description | We undertook a prospective longitudinal study of thyroid function in 60 normal pregnant women and measured serum concentrations of T
4, triiodothyronine (T
3), T-uptake, thyroxine binding globulin (TBG), free thyroxine index (FTI), free T
4, albumin and thyrotropin (TSH). From these data we established reference ranges for each of these analytes for each trimester and examined the interrelationships between laboratory measurements of thyroid function tests. We observed significant increases in serum concentrations of thyrotropin and decreases in free T
4, assays commonly used as first line investigations of thyroid activity during pregnancy. However, the 95th centile intervals for both analytes remained within the reference range for nonpregnant women. |
| doi_str_mv | 10.1016/0020-7292(82)90125-4 |
| format | Article |
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4, triiodothyronine (T
3), T-uptake, thyroxine binding globulin (TBG), free thyroxine index (FTI), free T
4, albumin and thyrotropin (TSH). From these data we established reference ranges for each of these analytes for each trimester and examined the interrelationships between laboratory measurements of thyroid function tests. We observed significant increases in serum concentrations of thyrotropin and decreases in free T
4, assays commonly used as first line investigations of thyroid activity during pregnancy. However, the 95th centile intervals for both analytes remained within the reference range for nonpregnant women.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/0020-7292(82)90125-4</identifier><identifier>PMID: 1360418</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Longitudinal Studies ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy - blood ; Pregnancy. Fetus. Placenta ; Prospective Studies ; Thyroid Hormones - blood ; Thyroid status ; Thyrotropin ; Thyroxin ; Thyroxin-binding globulin ; Triiodothyronine</subject><ispartof>International journal of gynecology and obstetrics, 1992-07, Vol.38 (3), p.171-179</ispartof><rights>1992</rights><rights>1992 International Federation of Gynecology and Obstetrics</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4361-29f9295691739072f9b9a7d49e7470b123c0c6de717abe463c3eab3bfaccb49c3</citedby><cites>FETCH-LOGICAL-c4361-29f9295691739072f9b9a7d49e7470b123c0c6de717abe463c3eab3bfaccb49c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2F0020-7292%2882%2990125-4$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0020729282901254$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,1411,3537,27901,27902,45550,45551,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5449539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1360418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Leary, P.C.</creatorcontrib><creatorcontrib>Boyne, P.</creatorcontrib><creatorcontrib>Atkinson, G.</creatorcontrib><creatorcontrib>Mileham, K.-J.</creatorcontrib><creatorcontrib>James, I.</creatorcontrib><title>Longitudinal study of serum thyroid hormone levels during normal pregnancy</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>We undertook a prospective longitudinal study of thyroid function in 60 normal pregnant women and measured serum concentrations of T
4, triiodothyronine (T
3), T-uptake, thyroxine binding globulin (TBG), free thyroxine index (FTI), free T
4, albumin and thyrotropin (TSH). From these data we established reference ranges for each of these analytes for each trimester and examined the interrelationships between laboratory measurements of thyroid function tests. We observed significant increases in serum concentrations of thyrotropin and decreases in free T
4, assays commonly used as first line investigations of thyroid activity during pregnancy. However, the 95th centile intervals for both analytes remained within the reference range for nonpregnant women.</description><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prospective Studies</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid status</subject><subject>Thyrotropin</subject><subject>Thyroxin</subject><subject>Thyroxin-binding globulin</subject><subject>Triiodothyronine</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFO3DAQhq2qCLa0b9BKOVSoHAIe2xvHFySEWgpaiQs9W44zWVwl9mJvQHl7vGRFb6gnW57vn_F8hHwFegYUqnNKGS0lU-xHzU4VBbYsxQeygFqqkgupPpLFG3JEPqX0l1IKEuCQHAKvqIB6QW5Xwa_ddmydN32R8mUqQlckjONQbB-mGFxbPIQ4BI9Fj0_Yp6Ido_PrwufXnNlEXHvj7fSZHHSmT_hlfx6TP79-3l_9Lld31zdXl6vSCl5ByVSnmFpWCiRXVLJONcrIViiUQtIGGLfUVi1KkKZBUXHL0TS86Yy1jVCWH5OTue8mhscR01YPLlnse-MxjElLznmtJGRQzKCNIaWInd5EN5g4aaB6p1Dv_OidH10z_apQixz7tu8_NgO2_0Kzs1z_vq-bZE3fxby8S2_YUgi15CpjasaeXY_Tf43WN7fXd_D684s5m3Xjk8Ook3XoLbYuot3qNrj3d3gB0qWdwA</recordid><startdate>199207</startdate><enddate>199207</enddate><creator>O'Leary, P.C.</creator><creator>Boyne, P.</creator><creator>Atkinson, G.</creator><creator>Mileham, K.-J.</creator><creator>James, I.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199207</creationdate><title>Longitudinal study of serum thyroid hormone levels during normal pregnancy</title><author>O'Leary, P.C. ; Boyne, P. ; Atkinson, G. ; Mileham, K.-J. ; James, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4361-29f9295691739072f9b9a7d49e7470b123c0c6de717abe463c3eab3bfaccb49c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prospective Studies</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid status</topic><topic>Thyrotropin</topic><topic>Thyroxin</topic><topic>Thyroxin-binding globulin</topic><topic>Triiodothyronine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Leary, P.C.</creatorcontrib><creatorcontrib>Boyne, P.</creatorcontrib><creatorcontrib>Atkinson, G.</creatorcontrib><creatorcontrib>Mileham, K.-J.</creatorcontrib><creatorcontrib>James, I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Leary, P.C.</au><au>Boyne, P.</au><au>Atkinson, G.</au><au>Mileham, K.-J.</au><au>James, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal study of serum thyroid hormone levels during normal pregnancy</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>1992-07</date><risdate>1992</risdate><volume>38</volume><issue>3</issue><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>We undertook a prospective longitudinal study of thyroid function in 60 normal pregnant women and measured serum concentrations of T
4, triiodothyronine (T
3), T-uptake, thyroxine binding globulin (TBG), free thyroxine index (FTI), free T
4, albumin and thyrotropin (TSH). From these data we established reference ranges for each of these analytes for each trimester and examined the interrelationships between laboratory measurements of thyroid function tests. We observed significant increases in serum concentrations of thyrotropin and decreases in free T
4, assays commonly used as first line investigations of thyroid activity during pregnancy. However, the 95th centile intervals for both analytes remained within the reference range for nonpregnant women.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1360418</pmid><doi>10.1016/0020-7292(82)90125-4</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of gynecology and obstetrics, 1992-07, Vol.38 (3), p.171-179 |
| issn | 0020-7292 1879-3479 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Female Gynecology. Andrology. Obstetrics Humans Longitudinal Studies Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy - blood Pregnancy. Fetus. Placenta Prospective Studies Thyroid Hormones - blood Thyroid status Thyrotropin Thyroxin Thyroxin-binding globulin Triiodothyronine |
| title | Longitudinal study of serum thyroid hormone levels during normal pregnancy |
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