Functionalized 4-Aminoquinolines by Rearrangement of Pyrazole N-Heterocyclic Carbenes

Thermal decarboxylation of 1‐phenylpyrazolium‐3‐carboxylates from the mesomeric betaine class of substances leads to pyrazole‐N‐heterocyclic carbenes, which immediately rearrange to multiply substituted 4‐aminoquinolines (see scheme). These species are of interest for the synthesis of heterocycles a...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-04, Vol.49 (15), p.2790-2793
Hauptverfasser:	Schmidt, Andreas, Münster, Niels, Dreger, Andrij
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - chemical synthesis Aminoquinolines - chemistry Antimalarials - chemistry carbenes Catalysis Coordination Complexes - chemistry heterocycles Heterocyclic Compounds - chemistry Methane - analogs & derivatives Methane - chemistry Pyrazoles - chemistry rearrangements synthetic methods zwitterions
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