An apparent decrease in cholesterol biosynthesis in peroxisomal-defective Chinese hamster ovary cells is related to impaired mitochondrial oxidation

Recent data suggest that impaired mitochondrial activities in Zellweger fibroblasts are related to defective peroxisome biogenesis and vice versa. To investigate the contribution of functional mitochondria to cholesterol biosynthesis, radioactive precursor molecules that form acetyl-CoA via β-oxidat...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-06, Vol.305 (4), p.957-963
Hauptverfasser:	Oettl, Karl, Höfler, Gerald, Ness, Gene C., Sattler, Wolfgang, Malle, Ernst
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Dioxide - metabolism Centrifugation, Density Gradient CHO Cells Cholesterol - biosynthesis Cholesterol Esters - biosynthesis Cholesterol, LDL - metabolism Cricetinae Kinetics Lipoproteins Membrane Proteins - genetics Mitochondria - metabolism Oxidation-Reduction Peroxisomal Biogenesis Factor 2 Peroxisomes - metabolism Point Mutation Radioactive tracer Radioactive Tracers Zellweger syndrome Zellweger Syndrome - metabolism
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