Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene
Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosi...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 2003-05, Vol.361 (9372), p.1871-1872 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1872 |
|---|---|
| container_issue | 9372 |
| container_start_page | 1871 |
| container_title | The Lancet (British edition) |
| container_volume | 361 |
| creator | Rossouw, Manda Nel, Hendrik J Cooke, Graham S van Helden, Paul D Hoal, Eileen G |
| description | Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A-->T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73337509</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73337509</sourcerecordid><originalsourceid>FETCH-LOGICAL-p547-62e107c5230fc94dfd7731c401a975758bd72ae3b9187914838bba6cff64a6c3</originalsourceid><addsrcrecordid>eNo1kLFOwzAURTOAaCn8AvLEFsmO7bxkLBWFShUMsEe289IaEtvYiVD_niDKdJZzz3AvsiVlguYl8HKRXaf0QSkVJZVX2YIVUFUSYJnhOiVvrBqtd0Tj-I3oyDhpjGbqfbKJKNcSRYLvT4OP4WgNedl-qhDUA9HWtdYdSLIjEjvvjr8YMXYY59xBDYMiB3R4k112qk94e-Yqe9s-vm-e8_3r026z3udBCsjLAhkFIwtOO1OLtmsBODOCMlWDBFnpFgqFXNesgpqJildaq9J0XSlm8FV2_1cN0X9NmMZmsMlg3yuHfkoNcM5B0noW787ipAdsmxDtoOKp-b-F_wDrNF6V</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73337509</pqid></control><display><type>article</type><title>Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>EBSCOhost Business Source Complete</source><source>ProQuest Central UK/Ireland</source><creator>Rossouw, Manda ; Nel, Hendrik J ; Cooke, Graham S ; van Helden, Paul D ; Hoal, Eileen G</creator><creatorcontrib>Rossouw, Manda ; Nel, Hendrik J ; Cooke, Graham S ; van Helden, Paul D ; Hoal, Eileen G</creatorcontrib><description>Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A-->T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis.</description><identifier>ISSN: 0140-6736</identifier><identifier>PMID: 12788577</identifier><language>eng</language><publisher>England</publisher><subject>Alleles ; Case-Control Studies ; Genetic Predisposition to Disease ; Humans ; Interferon-alpha - genetics ; NF-kappa B - genetics ; Polymorphism, Single Nucleotide ; South Africa ; Tuberculosis - genetics ; Tuberculosis - immunology</subject><ispartof>The Lancet (British edition), 2003-05, Vol.361 (9372), p.1871-1872</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,64387</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12788577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rossouw, Manda</creatorcontrib><creatorcontrib>Nel, Hendrik J</creatorcontrib><creatorcontrib>Cooke, Graham S</creatorcontrib><creatorcontrib>van Helden, Paul D</creatorcontrib><creatorcontrib>Hoal, Eileen G</creatorcontrib><title>Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A-->T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis.</description><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Interferon-alpha - genetics</subject><subject>NF-kappa B - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>South Africa</subject><subject>Tuberculosis - genetics</subject><subject>Tuberculosis - immunology</subject><issn>0140-6736</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLFOwzAURTOAaCn8AvLEFsmO7bxkLBWFShUMsEe289IaEtvYiVD_niDKdJZzz3AvsiVlguYl8HKRXaf0QSkVJZVX2YIVUFUSYJnhOiVvrBqtd0Tj-I3oyDhpjGbqfbKJKNcSRYLvT4OP4WgNedl-qhDUA9HWtdYdSLIjEjvvjr8YMXYY59xBDYMiB3R4k112qk94e-Yqe9s-vm-e8_3r026z3udBCsjLAhkFIwtOO1OLtmsBODOCMlWDBFnpFgqFXNesgpqJildaq9J0XSlm8FV2_1cN0X9NmMZmsMlg3yuHfkoNcM5B0noW787ipAdsmxDtoOKp-b-F_wDrNF6V</recordid><startdate>20030531</startdate><enddate>20030531</enddate><creator>Rossouw, Manda</creator><creator>Nel, Hendrik J</creator><creator>Cooke, Graham S</creator><creator>van Helden, Paul D</creator><creator>Hoal, Eileen G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030531</creationdate><title>Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene</title><author>Rossouw, Manda ; Nel, Hendrik J ; Cooke, Graham S ; van Helden, Paul D ; Hoal, Eileen G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-62e107c5230fc94dfd7731c401a975758bd72ae3b9187914838bba6cff64a6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Interferon-alpha - genetics</topic><topic>NF-kappa B - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>South Africa</topic><topic>Tuberculosis - genetics</topic><topic>Tuberculosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rossouw, Manda</creatorcontrib><creatorcontrib>Nel, Hendrik J</creatorcontrib><creatorcontrib>Cooke, Graham S</creatorcontrib><creatorcontrib>van Helden, Paul D</creatorcontrib><creatorcontrib>Hoal, Eileen G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rossouw, Manda</au><au>Nel, Hendrik J</au><au>Cooke, Graham S</au><au>van Helden, Paul D</au><au>Hoal, Eileen G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2003-05-31</date><risdate>2003</risdate><volume>361</volume><issue>9372</issue><spage>1871</spage><epage>1872</epage><pages>1871-1872</pages><issn>0140-6736</issn><abstract>Interferon gamma is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon gamma (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A-->T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis.</abstract><cop>England</cop><pmid>12788577</pmid><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2003-05, Vol.361 (9372), p.1871-1872 |
| issn | 0140-6736 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73337509 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EBSCOhost Business Source Complete; ProQuest Central UK/Ireland |
| subjects | Alleles Case-Control Studies Genetic Predisposition to Disease Humans Interferon-alpha - genetics NF-kappa B - genetics Polymorphism, Single Nucleotide South Africa Tuberculosis - genetics Tuberculosis - immunology |
| title | Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T15%3A08%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20tuberculosis%20and%20a%20polymorphic%20NFkappaB%20binding%20site%20in%20the%20interferon%20gamma%20gene&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Rossouw,%20Manda&rft.date=2003-05-31&rft.volume=361&rft.issue=9372&rft.spage=1871&rft.epage=1872&rft.pages=1871-1872&rft.issn=0140-6736&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E73337509%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73337509&rft_id=info:pmid/12788577&rfr_iscdi=true |