Genetic Parameters of Postnatal Mortality in Danish Holstein Calves
The objective of this study was to estimate genetic parameters of postnatal mortality (PM) in dairy cattle. Data originated from 841,921 Danish Holstein calves. Four binary traits of mortality were considered: D1-14, D15-60, D61-180, and D1-180 with numbers indicating the period of risk in days afte...
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| description | The objective of this study was to estimate genetic parameters of postnatal mortality (PM) in dairy cattle. Data originated from 841,921 Danish Holstein calves. Four binary traits of mortality were considered: D1-14, D15-60, D61-180, and D1-180 with numbers indicating the period of risk in days after birth. The unadjusted frequency of D1-14, D15-60, D61-180, and D1-180 were 0.027, 0.018, 0.020, and 0.066, respectively. A linear sire-model was fitted to the data, and average information-REML was used to estimate (co)variance components. Estimates of direct heritabilities for the four mortality traits ranged from 0.001 to 0.008 but were all significant. D61-180 and D1-180 had the highest direct heritabilities. Maternal heritabilities were very low, ranging from 0.0002 to 0.0015 and significant for D1-14 and D1-180 only. The direct genetic correlation between D1-14 and D15-60, between D15-60 and D61-180, and between D1-14 and D61-180 was 0.73, 0.54, and 0.34, respectively. It indicates that different genes are responsible for early PM (D1-14) and late PM (D61-180). When D61-180 was treated as a different trait for females, males not transferred, and transferred males, the direct heritability was 0.004, 0.008, and 0.034, respectively, but the direct genetic correlations between these three traits were very high. If transfers of calves are getting more common, the importance of including PM in a breeding program will increase, as the genetic variation of PM was considerably higher for transferred calves than for calves that were not transferred. |
| doi_str_mv | 10.3168/jds.S0022-0302(03)73766-7 |
| format | Article |
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Data originated from 841,921 Danish Holstein calves. Four binary traits of mortality were considered: D1-14, D15-60, D61-180, and D1-180 with numbers indicating the period of risk in days after birth. The unadjusted frequency of D1-14, D15-60, D61-180, and D1-180 were 0.027, 0.018, 0.020, and 0.066, respectively. A linear sire-model was fitted to the data, and average information-REML was used to estimate (co)variance components. Estimates of direct heritabilities for the four mortality traits ranged from 0.001 to 0.008 but were all significant. D61-180 and D1-180 had the highest direct heritabilities. Maternal heritabilities were very low, ranging from 0.0002 to 0.0015 and significant for D1-14 and D1-180 only. The direct genetic correlation between D1-14 and D15-60, between D15-60 and D61-180, and between D1-14 and D61-180 was 0.73, 0.54, and 0.34, respectively. It indicates that different genes are responsible for early PM (D1-14) and late PM (D61-180). When D61-180 was treated as a different trait for females, males not transferred, and transferred males, the direct heritability was 0.004, 0.008, and 0.034, respectively, but the direct genetic correlations between these three traits were very high. If transfers of calves are getting more common, the importance of including PM in a breeding program will increase, as the genetic variation of PM was considerably higher for transferred calves than for calves that were not transferred.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(03)73766-7</identifier><identifier>PMID: 12778591</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>age ; Aging ; animal diseases ; animal genetics ; Animal productions ; Animals ; Animals, Newborn - genetics ; Animals, Newborn - physiology ; Biological and medical sciences ; calf ; calves ; Cattle - genetics ; cattle diseases ; digestive system diseases ; Female ; Fundamental and applied biological sciences. Psychology ; gender differences ; gene expression ; genetic correlation ; genetic parameter ; Genetic Predisposition to Disease ; heritability ; Holstein ; Linear Models ; Male ; maternal effect ; Models, Genetic ; Mortality ; neonates ; Parity ; phenotype ; Pregnancy ; respiratory tract diseases ; risk groups ; Seasons ; selection criteria ; sire evaluation ; Terrestrial animal productions ; Time Factors ; twins ; Vertebrates</subject><ispartof>Journal of dairy science, 2003-05, Vol.86 (5), p.1807-1817</ispartof><rights>2003 American Dairy Science Association</rights><rights>2003 INIST-CNRS</rights><rights>Copyright American Dairy Science Association May 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-d549880c5d425404a33e8b6ae731dda0f43fc2e8ba9fa419a550be7a36dc41603</citedby><cites>FETCH-LOGICAL-c592t-d549880c5d425404a33e8b6ae731dda0f43fc2e8ba9fa419a550be7a36dc41603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.S0022-0302(03)73766-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14785985$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12778591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, M.</creatorcontrib><creatorcontrib>Madsen, P.</creatorcontrib><creatorcontrib>Jensen, J.</creatorcontrib><creatorcontrib>Pedersen, J.</creatorcontrib><creatorcontrib>Christensen, L.G.</creatorcontrib><title>Genetic Parameters of Postnatal Mortality in Danish Holstein Calves</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>The objective of this study was to estimate genetic parameters of postnatal mortality (PM) in dairy cattle. Data originated from 841,921 Danish Holstein calves. Four binary traits of mortality were considered: D1-14, D15-60, D61-180, and D1-180 with numbers indicating the period of risk in days after birth. The unadjusted frequency of D1-14, D15-60, D61-180, and D1-180 were 0.027, 0.018, 0.020, and 0.066, respectively. A linear sire-model was fitted to the data, and average information-REML was used to estimate (co)variance components. Estimates of direct heritabilities for the four mortality traits ranged from 0.001 to 0.008 but were all significant. D61-180 and D1-180 had the highest direct heritabilities. Maternal heritabilities were very low, ranging from 0.0002 to 0.0015 and significant for D1-14 and D1-180 only. The direct genetic correlation between D1-14 and D15-60, between D15-60 and D61-180, and between D1-14 and D61-180 was 0.73, 0.54, and 0.34, respectively. It indicates that different genes are responsible for early PM (D1-14) and late PM (D61-180). When D61-180 was treated as a different trait for females, males not transferred, and transferred males, the direct heritability was 0.004, 0.008, and 0.034, respectively, but the direct genetic correlations between these three traits were very high. If transfers of calves are getting more common, the importance of including PM in a breeding program will increase, as the genetic variation of PM was considerably higher for transferred calves than for calves that were not transferred.</description><subject>age</subject><subject>Aging</subject><subject>animal diseases</subject><subject>animal genetics</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Animals, Newborn - genetics</subject><subject>Animals, Newborn - physiology</subject><subject>Biological and medical sciences</subject><subject>calf</subject><subject>calves</subject><subject>Cattle - genetics</subject><subject>cattle diseases</subject><subject>digestive system diseases</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gender differences</subject><subject>gene expression</subject><subject>genetic correlation</subject><subject>genetic parameter</subject><subject>Genetic Predisposition to Disease</subject><subject>heritability</subject><subject>Holstein</subject><subject>Linear Models</subject><subject>Male</subject><subject>maternal effect</subject><subject>Models, Genetic</subject><subject>Mortality</subject><subject>neonates</subject><subject>Parity</subject><subject>phenotype</subject><subject>Pregnancy</subject><subject>respiratory tract diseases</subject><subject>risk groups</subject><subject>Seasons</subject><subject>selection criteria</subject><subject>sire evaluation</subject><subject>Terrestrial animal productions</subject><subject>Time Factors</subject><subject>twins</subject><subject>Vertebrates</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9v1DAQxS1ERZeFrwABCVQOKf4Tx_YRBWgrFVGp9GzNOpOuV0lc7GxRvz1Od8VKPXGZ0Vg_v-d5JuQdo6eC1frzpk2n15RyXlJB-QkVn5RQdV2qZ2TBJJelYEY_J4t_yDF5mdImj4xT-YIcM66UloYtSHOGI07eFVcQYcAJYypCV1yFNI0wQV_8CDE3Pz0Ufiy-wujTujgPfZowzw3095hekaMO-oSv931Jbr5_-9Wcl5c_zy6aL5elk4ZPZSsrozV1sq24rGgFQqBe1YBKsLYF2lWiczwfgemgYgakpCtUIOrWVaymYkk-7nTvYvi9xTTZwSeHfQ8jhm2ySgihJNUZfP8E3IRtHPPbLDNSUy3VrGZ2kIshpYidvYt-gPhgGbVzzDbHbB9jtnOGudjHmHNdkjd7g-1qwPZwc59rBj7sAUgO-i7C6Hw6cNWMaXlYae1v1398RJsG6Pssy2Z7XVtpmaaz49sd2EGwcBuz2M01p0xQaoQUps5EsyMwf8G9x2iT8zg6bLOsm2wb_H9s9hda57GH</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Hansen, M.</creator><creator>Madsen, P.</creator><creator>Jensen, J.</creator><creator>Pedersen, J.</creator><creator>Christensen, L.G.</creator><general>Elsevier Inc</general><general>Am Dairy Sci Assoc</general><general>American Dairy Science Association</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Genetic Parameters of Postnatal Mortality in Danish Holstein Calves</title><author>Hansen, M. ; Madsen, P. ; Jensen, J. ; Pedersen, J. ; Christensen, L.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-d549880c5d425404a33e8b6ae731dda0f43fc2e8ba9fa419a550be7a36dc41603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>age</topic><topic>Aging</topic><topic>animal diseases</topic><topic>animal genetics</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Animals, Newborn - genetics</topic><topic>Animals, Newborn - physiology</topic><topic>Biological and medical sciences</topic><topic>calf</topic><topic>calves</topic><topic>Cattle - genetics</topic><topic>cattle diseases</topic><topic>digestive system diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gender differences</topic><topic>gene expression</topic><topic>genetic correlation</topic><topic>genetic parameter</topic><topic>Genetic Predisposition to Disease</topic><topic>heritability</topic><topic>Holstein</topic><topic>Linear Models</topic><topic>Male</topic><topic>maternal effect</topic><topic>Models, Genetic</topic><topic>Mortality</topic><topic>neonates</topic><topic>Parity</topic><topic>phenotype</topic><topic>Pregnancy</topic><topic>respiratory tract diseases</topic><topic>risk groups</topic><topic>Seasons</topic><topic>selection criteria</topic><topic>sire evaluation</topic><topic>Terrestrial animal productions</topic><topic>Time Factors</topic><topic>twins</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, M.</creatorcontrib><creatorcontrib>Madsen, P.</creatorcontrib><creatorcontrib>Jensen, J.</creatorcontrib><creatorcontrib>Pedersen, J.</creatorcontrib><creatorcontrib>Christensen, L.G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, M.</au><au>Madsen, P.</au><au>Jensen, J.</au><au>Pedersen, J.</au><au>Christensen, L.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Parameters of Postnatal Mortality in Danish Holstein Calves</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>86</volume><issue>5</issue><spage>1807</spage><epage>1817</epage><pages>1807-1817</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>The objective of this study was to estimate genetic parameters of postnatal mortality (PM) in dairy cattle. Data originated from 841,921 Danish Holstein calves. Four binary traits of mortality were considered: D1-14, D15-60, D61-180, and D1-180 with numbers indicating the period of risk in days after birth. The unadjusted frequency of D1-14, D15-60, D61-180, and D1-180 were 0.027, 0.018, 0.020, and 0.066, respectively. A linear sire-model was fitted to the data, and average information-REML was used to estimate (co)variance components. Estimates of direct heritabilities for the four mortality traits ranged from 0.001 to 0.008 but were all significant. D61-180 and D1-180 had the highest direct heritabilities. Maternal heritabilities were very low, ranging from 0.0002 to 0.0015 and significant for D1-14 and D1-180 only. The direct genetic correlation between D1-14 and D15-60, between D15-60 and D61-180, and between D1-14 and D61-180 was 0.73, 0.54, and 0.34, respectively. It indicates that different genes are responsible for early PM (D1-14) and late PM (D61-180). When D61-180 was treated as a different trait for females, males not transferred, and transferred males, the direct heritability was 0.004, 0.008, and 0.034, respectively, but the direct genetic correlations between these three traits were very high. If transfers of calves are getting more common, the importance of including PM in a breeding program will increase, as the genetic variation of PM was considerably higher for transferred calves than for calves that were not transferred.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>12778591</pmid><doi>10.3168/jds.S0022-0302(03)73766-7</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | age Aging animal diseases animal genetics Animal productions Animals Animals, Newborn - genetics Animals, Newborn - physiology Biological and medical sciences calf calves Cattle - genetics cattle diseases digestive system diseases Female Fundamental and applied biological sciences. Psychology gender differences gene expression genetic correlation genetic parameter Genetic Predisposition to Disease heritability Holstein Linear Models Male maternal effect Models, Genetic Mortality neonates Parity phenotype Pregnancy respiratory tract diseases risk groups Seasons selection criteria sire evaluation Terrestrial animal productions Time Factors twins Vertebrates |
| title | Genetic Parameters of Postnatal Mortality in Danish Holstein Calves |
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