Mechanisms of inflammation in gout
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome...
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| Veröffentlicht in: | Arthritis research & therapy 2010-01, Vol.12 (2), p.206-206 |
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| creator | BUSSO, Nathalie SO, Alexander |
| description | An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research. |
| doi_str_mv | 10.1186/ar2952 |
| format | Article |
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Osteoarticular involvement in other diseases</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein</subject><subject>Other metabolic disorders</subject><subject>Phagocytosis</subject><subject>Purines and pyrimidines (gout, hyperuricemia...)</subject><subject>Uric Acid - immunology</subject><issn>1478-6354</issn><issn>1478-6362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAgiruu-hOkCOqpOvnoJD3K4heseNFzmU0TrfRjTdqD_97K1vU0M_DwwryMnXK45tzgDQWRZ2KPzbnSJkWJYn-3Z2rGjmL8BBAiF-qQzQQoxRGyOTt_dvaD2io2Mel8UrW-pqahvura8Ujeu6E_Zgee6uhOprlgb_d3r8vHdPXy8LS8XaVWIvapIS2090gKAQxIWCudc9Sly3OVA3BnCDP0CqxWhgssOVprkTRmYI2XC3a1zd2E7mtwsS-aKlpX19S6boiFllJqwYUa5eVW2tDFGJwvNqFqKHwXHIrfOoptHSM8myKHdePKHfv7fwQXE6BoqfaBWlvFfyeMMtJk8geJ4GPn</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>BUSSO, Nathalie</creator><creator>SO, Alexander</creator><general>BioMed Central</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Mechanisms of inflammation in gout</title><author>BUSSO, Nathalie ; SO, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-8a727ff6a46008030b479167de9949001e8a656f40c748126d16ccc6a7650c8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - immunology</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Crystallization</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Gout - immunology</topic><topic>Gout - pathology</topic><topic>Humans</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Inflammatory joint diseases</topic><topic>Interleukin-1beta - secretion</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - pathology</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Miscellaneous. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Acute Disease Animals Biological and medical sciences Carrier Proteins - immunology Chemotaxis, Leukocyte - immunology Crystallization Disease Models, Animal Diseases of the osteoarticular system Gout - immunology Gout - pathology Humans Inflammation - immunology Inflammation - pathology Inflammatory joint diseases Interleukin-1beta - secretion Leukocytes - immunology Leukocytes - pathology Medical sciences Metabolic diseases Miscellaneous. Osteoarticular involvement in other diseases NLR Family, Pyrin Domain-Containing 3 Protein Other metabolic disorders Phagocytosis Purines and pyrimidines (gout, hyperuricemia...) Uric Acid - immunology |
| title | Mechanisms of inflammation in gout |
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